Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children

<p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B ce...
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Autor*in:	Ng'ang'a Zipporah W [verfasserIn] Kiprotich Chelimo [verfasserIn] Moormann Ann M [verfasserIn] Asito Amolo S [verfasserIn] Ploutz-Snyder Robert [verfasserIn] Rochford Rosemary [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	In: Malaria Journal - BMC, 2003, 7(2008), 1, p 238
Übergeordnetes Werk:	volume:7 ; year:2008 ; number:1, p 238

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1475-2875-7-238

Katalog-ID:	DOAJ057732515

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p<
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author_variant	n z w nzw k c kc m a m mam a a s aas p s r psr r r rr
matchkey_str	article:14752875:2008----::leainoprpeabelustfloignctucmlctdlncl
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publishDate	2008
allfields	10.1186/1475-2875-7-238 doi (DE-627)DOAJ057732515 (DE-599)DOAJa83a295d026b40ef9ed46eddecadc6aa DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Ng'ang'a Zipporah W verfasserin aut Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p< Arctic medicine. Tropical medicine Infectious and parasitic diseases Kiprotich Chelimo verfasserin aut Moormann Ann M verfasserin aut Asito Amolo S verfasserin aut Ploutz-Snyder Robert verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 7(2008), 1, p 238 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:7 year:2008 number:1, p 238 https://doi.org/10.1186/1475-2875-7-238 kostenfrei https://doaj.org/article/a83a295d026b40ef9ed46eddecadc6aa kostenfrei http://www.malariajournal.com/content/7/1/238 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2008 1, p 238
spelling	10.1186/1475-2875-7-238 doi (DE-627)DOAJ057732515 (DE-599)DOAJa83a295d026b40ef9ed46eddecadc6aa DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Ng'ang'a Zipporah W verfasserin aut Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p< Arctic medicine. Tropical medicine Infectious and parasitic diseases Kiprotich Chelimo verfasserin aut Moormann Ann M verfasserin aut Asito Amolo S verfasserin aut Ploutz-Snyder Robert verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 7(2008), 1, p 238 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:7 year:2008 number:1, p 238 https://doi.org/10.1186/1475-2875-7-238 kostenfrei https://doaj.org/article/a83a295d026b40ef9ed46eddecadc6aa kostenfrei http://www.malariajournal.com/content/7/1/238 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2008 1, p 238
allfields_unstemmed	10.1186/1475-2875-7-238 doi (DE-627)DOAJ057732515 (DE-599)DOAJa83a295d026b40ef9ed46eddecadc6aa DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Ng'ang'a Zipporah W verfasserin aut Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p< Arctic medicine. Tropical medicine Infectious and parasitic diseases Kiprotich Chelimo verfasserin aut Moormann Ann M verfasserin aut Asito Amolo S verfasserin aut Ploutz-Snyder Robert verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 7(2008), 1, p 238 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:7 year:2008 number:1, p 238 https://doi.org/10.1186/1475-2875-7-238 kostenfrei https://doaj.org/article/a83a295d026b40ef9ed46eddecadc6aa kostenfrei http://www.malariajournal.com/content/7/1/238 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2008 1, p 238
allfieldsGer	10.1186/1475-2875-7-238 doi (DE-627)DOAJ057732515 (DE-599)DOAJa83a295d026b40ef9ed46eddecadc6aa DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Ng'ang'a Zipporah W verfasserin aut Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p< Arctic medicine. Tropical medicine Infectious and parasitic diseases Kiprotich Chelimo verfasserin aut Moormann Ann M verfasserin aut Asito Amolo S verfasserin aut Ploutz-Snyder Robert verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 7(2008), 1, p 238 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:7 year:2008 number:1, p 238 https://doi.org/10.1186/1475-2875-7-238 kostenfrei https://doaj.org/article/a83a295d026b40ef9ed46eddecadc6aa kostenfrei http://www.malariajournal.com/content/7/1/238 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2008 1, p 238
allfieldsSound	10.1186/1475-2875-7-238 doi (DE-627)DOAJ057732515 (DE-599)DOAJa83a295d026b40ef9ed46eddecadc6aa DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Ng'ang'a Zipporah W verfasserin aut Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p< Arctic medicine. Tropical medicine Infectious and parasitic diseases Kiprotich Chelimo verfasserin aut Moormann Ann M verfasserin aut Asito Amolo S verfasserin aut Ploutz-Snyder Robert verfasserin aut Rochford Rosemary verfasserin aut In Malaria Journal BMC, 2003 7(2008), 1, p 238 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:7 year:2008 number:1, p 238 https://doi.org/10.1186/1475-2875-7-238 kostenfrei https://doaj.org/article/a83a295d026b40ef9ed46eddecadc6aa kostenfrei http://www.malariajournal.com/content/7/1/238 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2008 1, p 238
language	English
source	In Malaria Journal 7(2008), 1, p 238 volume:7 year:2008 number:1, p 238
sourceStr	In Malaria Journal 7(2008), 1, p 238 volume:7 year:2008 number:1, p 238
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Arctic medicine. Tropical medicine Infectious and parasitic diseases
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container_title	Malaria Journal
authorswithroles_txt_mv	Ng'ang'a Zipporah W @@aut@@ Kiprotich Chelimo @@aut@@ Moormann Ann M @@aut@@ Asito Amolo S @@aut@@ Ploutz-Snyder Robert @@aut@@ Rochford Rosemary @@aut@@
publishDateDaySort_date	2008-01-01T00:00:00Z
hierarchy_top_id	355986582
id	DOAJ057732515
language_de	englisch
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callnumber-first	R - Medicine
author	Ng'ang'a Zipporah W
spellingShingle	Ng'ang'a Zipporah W misc RC955-962 misc RC109-216 misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
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topic_title	RC955-962 RC109-216 Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
topic	misc RC955-962 misc RC109-216 misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases
topic_unstemmed	misc RC955-962 misc RC109-216 misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases
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title	Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
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title_full	Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
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author_browse	Ng'ang'a Zipporah W Kiprotich Chelimo Moormann Ann M Asito Amolo S Ploutz-Snyder Robert Rochford Rosemary
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class	RC955-962 RC109-216
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author-letter	Ng'ang'a Zipporah W
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author2-role	verfasserin
title_sort	alterations on peripheral b cell subsets following an acute uncomplicated clinical malaria infection in children
callnumber	RC955-962
title_auth	Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
abstract	<p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The effects of <it<Plasmodium falciparum </it<on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.</p< <p<Methods</p< <p<Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.</p< <p<Results</p< <p<There was a significant decrease in CD19<sup<+ </sup<B lymphocytes during acute malaria. Characterization of the CD19<sup<+ </sup<B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38<sup<-</sup<IgD<sup<+ </sup<B cells while there was an increase in CD38<sup<+</sup<IgD<sup<- </sup<memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10<sup<+</sup<CD19<sup<+ </sup<B cells in children following an episode of acute malaria with up to 25% of total CD19<sup<+ </sup<B cell pool residing in this subset.</p< <p<Conclusion</p< <p<Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.</p<
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container_issue	1, p 238
title_short	Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
url	https://doi.org/10.1186/1475-2875-7-238 https://doaj.org/article/a83a295d026b40ef9ed46eddecadc6aa http://www.malariajournal.com/content/7/1/238 https://doaj.org/toc/1475-2875
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Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children

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