The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials

Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supp...
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Autor*in:	Cain C. T. Clark [verfasserIn] Mina Salek [verfasserIn] Elahe Aghabagheri [verfasserIn] Sadegh Jafarnejad [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	psyllium dietary fiber blood pressure meta-analysis

Übergeordnetes Werk:	In: The Korean Journal of Internal Medicine - The Korean Association of Internal Medicine, 2019, 35(2020), 6, Seite 1385-1399
Übergeordnetes Werk:	volume:35 ; year:2020 ; number:6 ; pages:1385-1399

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3904/kjim.2019.049

Katalog-ID:	DOAJ057769508

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520			\|a Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms.
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allfields	10.3904/kjim.2019.049 doi (DE-627)DOAJ057769508 (DE-599)DOAJb4ed2956809745de96f697d19547d36d DE-627 ger DE-627 rakwb eng Cain C. T. Clark verfasserin aut The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms. psyllium dietary fiber blood pressure meta-analysis Medicine R Mina Salek verfasserin aut Elahe Aghabagheri verfasserin aut Sadegh Jafarnejad verfasserin aut In The Korean Journal of Internal Medicine The Korean Association of Internal Medicine, 2019 35(2020), 6, Seite 1385-1399 (DE-627)602537371 (DE-600)2500508-X 20056648 nnns volume:35 year:2020 number:6 pages:1385-1399 https://doi.org/10.3904/kjim.2019.049 kostenfrei https://doaj.org/article/b4ed2956809745de96f697d19547d36d kostenfrei http://www.kjim.org/upload/pdf/kjim-2019-049.pdf kostenfrei https://doaj.org/toc/1226-3303 Journal toc kostenfrei https://doaj.org/toc/2005-6648 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2020 6 1385-1399
spelling	10.3904/kjim.2019.049 doi (DE-627)DOAJ057769508 (DE-599)DOAJb4ed2956809745de96f697d19547d36d DE-627 ger DE-627 rakwb eng Cain C. T. Clark verfasserin aut The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms. psyllium dietary fiber blood pressure meta-analysis Medicine R Mina Salek verfasserin aut Elahe Aghabagheri verfasserin aut Sadegh Jafarnejad verfasserin aut In The Korean Journal of Internal Medicine The Korean Association of Internal Medicine, 2019 35(2020), 6, Seite 1385-1399 (DE-627)602537371 (DE-600)2500508-X 20056648 nnns volume:35 year:2020 number:6 pages:1385-1399 https://doi.org/10.3904/kjim.2019.049 kostenfrei https://doaj.org/article/b4ed2956809745de96f697d19547d36d kostenfrei http://www.kjim.org/upload/pdf/kjim-2019-049.pdf kostenfrei https://doaj.org/toc/1226-3303 Journal toc kostenfrei https://doaj.org/toc/2005-6648 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2020 6 1385-1399
allfields_unstemmed	10.3904/kjim.2019.049 doi (DE-627)DOAJ057769508 (DE-599)DOAJb4ed2956809745de96f697d19547d36d DE-627 ger DE-627 rakwb eng Cain C. T. Clark verfasserin aut The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms. psyllium dietary fiber blood pressure meta-analysis Medicine R Mina Salek verfasserin aut Elahe Aghabagheri verfasserin aut Sadegh Jafarnejad verfasserin aut In The Korean Journal of Internal Medicine The Korean Association of Internal Medicine, 2019 35(2020), 6, Seite 1385-1399 (DE-627)602537371 (DE-600)2500508-X 20056648 nnns volume:35 year:2020 number:6 pages:1385-1399 https://doi.org/10.3904/kjim.2019.049 kostenfrei https://doaj.org/article/b4ed2956809745de96f697d19547d36d kostenfrei http://www.kjim.org/upload/pdf/kjim-2019-049.pdf kostenfrei https://doaj.org/toc/1226-3303 Journal toc kostenfrei https://doaj.org/toc/2005-6648 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2020 6 1385-1399
allfieldsGer	10.3904/kjim.2019.049 doi (DE-627)DOAJ057769508 (DE-599)DOAJb4ed2956809745de96f697d19547d36d DE-627 ger DE-627 rakwb eng Cain C. T. Clark verfasserin aut The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms. psyllium dietary fiber blood pressure meta-analysis Medicine R Mina Salek verfasserin aut Elahe Aghabagheri verfasserin aut Sadegh Jafarnejad verfasserin aut In The Korean Journal of Internal Medicine The Korean Association of Internal Medicine, 2019 35(2020), 6, Seite 1385-1399 (DE-627)602537371 (DE-600)2500508-X 20056648 nnns volume:35 year:2020 number:6 pages:1385-1399 https://doi.org/10.3904/kjim.2019.049 kostenfrei https://doaj.org/article/b4ed2956809745de96f697d19547d36d kostenfrei http://www.kjim.org/upload/pdf/kjim-2019-049.pdf kostenfrei https://doaj.org/toc/1226-3303 Journal toc kostenfrei https://doaj.org/toc/2005-6648 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2020 6 1385-1399
allfieldsSound	10.3904/kjim.2019.049 doi (DE-627)DOAJ057769508 (DE-599)DOAJb4ed2956809745de96f697d19547d36d DE-627 ger DE-627 rakwb eng Cain C. T. Clark verfasserin aut The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms. psyllium dietary fiber blood pressure meta-analysis Medicine R Mina Salek verfasserin aut Elahe Aghabagheri verfasserin aut Sadegh Jafarnejad verfasserin aut In The Korean Journal of Internal Medicine The Korean Association of Internal Medicine, 2019 35(2020), 6, Seite 1385-1399 (DE-627)602537371 (DE-600)2500508-X 20056648 nnns volume:35 year:2020 number:6 pages:1385-1399 https://doi.org/10.3904/kjim.2019.049 kostenfrei https://doaj.org/article/b4ed2956809745de96f697d19547d36d kostenfrei http://www.kjim.org/upload/pdf/kjim-2019-049.pdf kostenfrei https://doaj.org/toc/1226-3303 Journal toc kostenfrei https://doaj.org/toc/2005-6648 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 35 2020 6 1385-1399
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Clark</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. 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author	Cain C. T. Clark
spellingShingle	Cain C. T. Clark misc psyllium misc dietary fiber misc blood pressure misc meta-analysis misc Medicine misc R The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
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topic_title	The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials psyllium dietary fiber blood pressure meta-analysis
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title	The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
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author_browse	Cain C. T. Clark Mina Salek Elahe Aghabagheri Sadegh Jafarnejad
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title_sort	effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
title_auth	The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
abstract	Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms.
abstractGer	Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms.
abstract_unstemmed	Background/Aims Global incidence of hypertension is estimated to be, in excess of, one billion people, and given the efficacy of soluble dietary fibers, in particular, Psyllium, to positively impact blood pressure in patients with hypertension, it is of clinical importance that consensus on its supplementation be established. Therefore, the aim of the study was systematically review and meta-analyze the effect of psyllium supplementation on blood pressure of hypertensive patients in randomized controlled trials. Methods We searched six universal databases including; Pubmed/Medline, Ovid, Cochrane Library, Google Scholar, Embase, and Scopus until November 2018. Both combined and stratiﬁed analyzes were conducted. A fixed-effects or random- effects model was used to assess the mean effect sizes. Results An eventual 11 trials with 592 participants were considered as eligible for inclusion in the present meta-analysis. The meta-analysis revealed a significant reduction of 2.04 mmHg in systolic blood pressure (weighted mean difference, –2.04; 95% confidence interval, –2.82 to –1.63; p < 0.001). Whilst meta-regression highlighted that the hypotensive effect of psyllium was stronger in subjects with higher baseline blood pressure. Conclusions Given the overarching benefits and lack of reported side effects, particularly for hypertensive patients, health care providers and clinicians should consider the use of psyllium supplementation for the treatment or abatement of hypertension, or hypertensive symptoms.
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title_short	The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
url	https://doi.org/10.3904/kjim.2019.049 https://doaj.org/article/b4ed2956809745de96f697d19547d36d http://www.kjim.org/upload/pdf/kjim-2019-049.pdf https://doaj.org/toc/1226-3303 https://doaj.org/toc/2005-6648
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author2	Mina Salek Elahe Aghabagheri Sadegh Jafarnejad
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