Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis

Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality...
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Autor*in:	Aparna Iyer [verfasserIn] Teodora Radonic [verfasserIn] Lukas C. Heukamp [verfasserIn] Erik Thunnissen [verfasserIn] Johannes M.A. Daniels [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: ERJ Open Research - European Respiratory Society, 2015, 7(2021), 1
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1183/23120541.00151-2020

Katalog-ID:	DOAJ057787921

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allfields	10.1183/23120541.00151-2020 doi (DE-627)DOAJ057787921 (DE-599)DOAJ4e258299049a4d389e43ad67ce587e37 DE-627 ger DE-627 rakwb eng Aparna Iyer verfasserin aut Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases. Medicine R Teodora Radonic verfasserin aut Lukas C. Heukamp verfasserin aut Erik Thunnissen verfasserin aut Johannes M.A. Daniels verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00151-2020 kostenfrei https://doaj.org/article/4e258299049a4d389e43ad67ce587e37 kostenfrei http://openres.ersjournals.com/content/7/1/00151-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
spelling	10.1183/23120541.00151-2020 doi (DE-627)DOAJ057787921 (DE-599)DOAJ4e258299049a4d389e43ad67ce587e37 DE-627 ger DE-627 rakwb eng Aparna Iyer verfasserin aut Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases. Medicine R Teodora Radonic verfasserin aut Lukas C. Heukamp verfasserin aut Erik Thunnissen verfasserin aut Johannes M.A. Daniels verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00151-2020 kostenfrei https://doaj.org/article/4e258299049a4d389e43ad67ce587e37 kostenfrei http://openres.ersjournals.com/content/7/1/00151-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
allfields_unstemmed	10.1183/23120541.00151-2020 doi (DE-627)DOAJ057787921 (DE-599)DOAJ4e258299049a4d389e43ad67ce587e37 DE-627 ger DE-627 rakwb eng Aparna Iyer verfasserin aut Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases. Medicine R Teodora Radonic verfasserin aut Lukas C. Heukamp verfasserin aut Erik Thunnissen verfasserin aut Johannes M.A. Daniels verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00151-2020 kostenfrei https://doaj.org/article/4e258299049a4d389e43ad67ce587e37 kostenfrei http://openres.ersjournals.com/content/7/1/00151-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
allfieldsGer	10.1183/23120541.00151-2020 doi (DE-627)DOAJ057787921 (DE-599)DOAJ4e258299049a4d389e43ad67ce587e37 DE-627 ger DE-627 rakwb eng Aparna Iyer verfasserin aut Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases. Medicine R Teodora Radonic verfasserin aut Lukas C. Heukamp verfasserin aut Erik Thunnissen verfasserin aut Johannes M.A. Daniels verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00151-2020 kostenfrei https://doaj.org/article/4e258299049a4d389e43ad67ce587e37 kostenfrei http://openres.ersjournals.com/content/7/1/00151-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
allfieldsSound	10.1183/23120541.00151-2020 doi (DE-627)DOAJ057787921 (DE-599)DOAJ4e258299049a4d389e43ad67ce587e37 DE-627 ger DE-627 rakwb eng Aparna Iyer verfasserin aut Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases. Medicine R Teodora Radonic verfasserin aut Lukas C. Heukamp verfasserin aut Erik Thunnissen verfasserin aut Johannes M.A. Daniels verfasserin aut In ERJ Open Research European Respiratory Society, 2015 7(2021), 1 (DE-627)830141227 (DE-600)2827830-6 23120541 nnns volume:7 year:2021 number:1 https://doi.org/10.1183/23120541.00151-2020 kostenfrei https://doaj.org/article/4e258299049a4d389e43ad67ce587e37 kostenfrei http://openres.ersjournals.com/content/7/1/00151-2020.full kostenfrei https://doaj.org/toc/2312-0541 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1
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author	Aparna Iyer
spellingShingle	Aparna Iyer misc Medicine misc R Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
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topic_title	Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
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title	Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
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title_full	Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
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author_browse	Aparna Iyer Teodora Radonic Lukas C. Heukamp Erik Thunnissen Johannes M.A. Daniels
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title_sort	inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
title_auth	Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
abstract	Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases.
abstractGer	Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases.
abstract_unstemmed	Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases.
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title_short	Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
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