Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans

Hypercholesterolemia is a risk factor for coronary heart disease (CHD) and also could contribute to impaired immune response. The National Cholesterol Education Program Expert Panel recommends a therapeutic lifestyle change (TLC) diet to reduce the risk for CHD. We investigated the effects of changi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sung Nim Han [verfasserIn] Lynette S. Leka [verfasserIn] Alice H. Lichtenstein [verfasserIn] Lynne M. Ausman [verfasserIn] Simin N. Meydani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Schlagwörter:	low-fat diet immune response dietary fat inflammatory response

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 44(2003), 12, Seite 2304-2310
Übergeordnetes Werk:	volume:44 ; year:2003 ; number:12 ; pages:2304-2310

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M300181-JLR200

Katalog-ID:	DOAJ057906653

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callnumber-first	Q - Science
author	Sung Nim Han
spellingShingle	Sung Nim Han misc QD415-436 misc low-fat diet misc immune response misc dietary fat misc inflammatory response misc Biochemistry Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
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topic_title	QD415-436 Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans low-fat diet immune response dietary fat inflammatory response
topic	misc QD415-436 misc low-fat diet misc immune response misc dietary fat misc inflammatory response misc Biochemistry
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title	Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
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title_full	Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
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author_browse	Sung Nim Han Lynette S. Leka Alice H. Lichtenstein Lynne M. Ausman Simin N. Meydani
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title_sort	effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
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title_auth	Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
abstract	Hypercholesterolemia is a risk factor for coronary heart disease (CHD) and also could contribute to impaired immune response. The National Cholesterol Education Program Expert Panel recommends a therapeutic lifestyle change (TLC) diet to reduce the risk for CHD. We investigated the effects of changing from a high-fat Western diet to a low-fat diet in accordance with a TLC diet on immune functions of older adults with hypercholesterolemia to determine whether improving the lipid profile via dietary intervention would have beneficial effects on immune functions. In a double-blind study, 18 subjects consumed both a Western diet (38% fat) and a TLC diet (28% fat) for 32 days in a randomized order. Measures of cellular immune responses, including delayed-type hypersensitivity (DTH) response, in vitro lymphocyte proliferation, and interleukin (IL)-2 production, and production of proinflammatory mediators, including tumor necrosis factor-α, IL-6, IL-1β, and prostaglandin E2, were determined. DTH response and lymphocyte proliferative response increased significantly (29% and 27%, respectively) after consumption of a TLC diet.Our results indicate that consumption of a TLC diet enhances T cell-mediated immune functions in older adults with elevated cholesterol level. This might be a clinically important benefit, considering the decline of T cell-mediated immune functions with aging and evidence of impaired immune function associated with hypercholesterolemia.
abstractGer	Hypercholesterolemia is a risk factor for coronary heart disease (CHD) and also could contribute to impaired immune response. The National Cholesterol Education Program Expert Panel recommends a therapeutic lifestyle change (TLC) diet to reduce the risk for CHD. We investigated the effects of changing from a high-fat Western diet to a low-fat diet in accordance with a TLC diet on immune functions of older adults with hypercholesterolemia to determine whether improving the lipid profile via dietary intervention would have beneficial effects on immune functions. In a double-blind study, 18 subjects consumed both a Western diet (38% fat) and a TLC diet (28% fat) for 32 days in a randomized order. Measures of cellular immune responses, including delayed-type hypersensitivity (DTH) response, in vitro lymphocyte proliferation, and interleukin (IL)-2 production, and production of proinflammatory mediators, including tumor necrosis factor-α, IL-6, IL-1β, and prostaglandin E2, were determined. DTH response and lymphocyte proliferative response increased significantly (29% and 27%, respectively) after consumption of a TLC diet.Our results indicate that consumption of a TLC diet enhances T cell-mediated immune functions in older adults with elevated cholesterol level. This might be a clinically important benefit, considering the decline of T cell-mediated immune functions with aging and evidence of impaired immune function associated with hypercholesterolemia.
abstract_unstemmed	Hypercholesterolemia is a risk factor for coronary heart disease (CHD) and also could contribute to impaired immune response. The National Cholesterol Education Program Expert Panel recommends a therapeutic lifestyle change (TLC) diet to reduce the risk for CHD. We investigated the effects of changing from a high-fat Western diet to a low-fat diet in accordance with a TLC diet on immune functions of older adults with hypercholesterolemia to determine whether improving the lipid profile via dietary intervention would have beneficial effects on immune functions. In a double-blind study, 18 subjects consumed both a Western diet (38% fat) and a TLC diet (28% fat) for 32 days in a randomized order. Measures of cellular immune responses, including delayed-type hypersensitivity (DTH) response, in vitro lymphocyte proliferation, and interleukin (IL)-2 production, and production of proinflammatory mediators, including tumor necrosis factor-α, IL-6, IL-1β, and prostaglandin E2, were determined. DTH response and lymphocyte proliferative response increased significantly (29% and 27%, respectively) after consumption of a TLC diet.Our results indicate that consumption of a TLC diet enhances T cell-mediated immune functions in older adults with elevated cholesterol level. This might be a clinically important benefit, considering the decline of T cell-mediated immune functions with aging and evidence of impaired immune function associated with hypercholesterolemia.
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title_short	Effect of a therapeutic lifestyle change diet on immune functions of moderately hypercholesterolemic humans
url	https://doi.org/10.1194/jlr.M300181-JLR200 https://doaj.org/article/7ac40efb38b64ec7861f6b769e800d55 http://www.sciencedirect.com/science/article/pii/S0022227520319489 https://doaj.org/toc/0022-2275
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author2	Lynette S. Leka Alice H. Lichtenstein Lynne M. Ausman Simin N. Meydani
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up_date	2024-07-03T14:50:35.130Z
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