Local and global Ca2+ signals: physiology and pathophysiology

The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	OLE H. PETERSEN [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2004

Schlagwörter:	Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals

Übergeordnetes Werk:	In: Biological Research - BMC, 2018, 37(2004), 4, Seite 661-664
Übergeordnetes Werk:	volume:37 ; year:2004 ; number:4 ; pages:661-664

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ05796694X

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ05796694X
003	DE-627
005	20230308221932.0
007	cr uuu---uuuuu
008	230227s2004 xx \|\|\|\|\|o 00\| \|\|eng c
035			\|a (DE-627)DOAJ05796694X
035			\|a (DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a QH301-705.5
100	0		\|a OLE H. PETERSEN \|e verfasserin \|4 aut
245	1	0	\|a Local and global Ca2+ signals: physiology and pathophysiology
264		1	\|c 2004
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.
650		4	\|a Pancreatic Acinar Cell
650		4	\|a Intracellular Communication
650		4	\|a Ca2+ Signal Compartmentalization
650		4	\|a Ca2+ Release Mechanisms
650		4	\|a Local Ca2+ Signals
653		0	\|a Biology (General)
773	0	8	\|i In \|t Biological Research \|d BMC, 2018 \|g 37(2004), 4, Seite 661-664 \|w (DE-627)329975374 \|w (DE-600)2048380-6 \|x 07176287 \|7 nnns
773	1	8	\|g volume:37 \|g year:2004 \|g number:4 \|g pages:661-664
856	4	0	\|u https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b \|z kostenfrei
856	4	0	\|u http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/0716-9760 \|y Journal toc \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/0717-6287 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 37 \|j 2004 \|e 4 \|h 661-664

Indexfelder

author_variant	o h p ohp
matchkey_str	article:07176287:2004----::oaadlblasgashsooynp
hierarchy_sort_str	2004
callnumber-subject-code	QH
publishDate	2004
allfields	(DE-627)DOAJ05796694X (DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b DE-627 ger DE-627 rakwb eng QH301-705.5 OLE H. PETERSEN verfasserin aut Local and global Ca2+ signals: physiology and pathophysiology 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself. Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals Biology (General) In Biological Research BMC, 2018 37(2004), 4, Seite 661-664 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:37 year:2004 number:4 pages:661-664 https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2004 4 661-664
spelling	(DE-627)DOAJ05796694X (DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b DE-627 ger DE-627 rakwb eng QH301-705.5 OLE H. PETERSEN verfasserin aut Local and global Ca2+ signals: physiology and pathophysiology 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself. Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals Biology (General) In Biological Research BMC, 2018 37(2004), 4, Seite 661-664 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:37 year:2004 number:4 pages:661-664 https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2004 4 661-664
allfields_unstemmed	(DE-627)DOAJ05796694X (DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b DE-627 ger DE-627 rakwb eng QH301-705.5 OLE H. PETERSEN verfasserin aut Local and global Ca2+ signals: physiology and pathophysiology 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself. Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals Biology (General) In Biological Research BMC, 2018 37(2004), 4, Seite 661-664 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:37 year:2004 number:4 pages:661-664 https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2004 4 661-664
allfieldsGer	(DE-627)DOAJ05796694X (DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b DE-627 ger DE-627 rakwb eng QH301-705.5 OLE H. PETERSEN verfasserin aut Local and global Ca2+ signals: physiology and pathophysiology 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself. Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals Biology (General) In Biological Research BMC, 2018 37(2004), 4, Seite 661-664 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:37 year:2004 number:4 pages:661-664 https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2004 4 661-664
allfieldsSound	(DE-627)DOAJ05796694X (DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b DE-627 ger DE-627 rakwb eng QH301-705.5 OLE H. PETERSEN verfasserin aut Local and global Ca2+ signals: physiology and pathophysiology 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself. Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals Biology (General) In Biological Research BMC, 2018 37(2004), 4, Seite 661-664 (DE-627)329975374 (DE-600)2048380-6 07176287 nnns volume:37 year:2004 number:4 pages:661-664 https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b kostenfrei http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023 kostenfrei https://doaj.org/toc/0716-9760 Journal toc kostenfrei https://doaj.org/toc/0717-6287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2004 4 661-664
language	English
source	In Biological Research 37(2004), 4, Seite 661-664 volume:37 year:2004 number:4 pages:661-664
sourceStr	In Biological Research 37(2004), 4, Seite 661-664 volume:37 year:2004 number:4 pages:661-664
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals Biology (General)
isfreeaccess_bool	true
container_title	Biological Research
authorswithroles_txt_mv	OLE H. PETERSEN @@aut@@
publishDateDaySort_date	2004-01-01T00:00:00Z
hierarchy_top_id	329975374
id	DOAJ05796694X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ05796694X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308221932.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2004 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ05796694X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">OLE H. PETERSEN</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Local and global Ca2+ signals: physiology and pathophysiology</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2004</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pancreatic Acinar Cell</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intracellular Communication</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ca2+ Signal Compartmentalization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ca2+ Release Mechanisms</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Local Ca2+ Signals</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biology (General)</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biological Research</subfield><subfield code="d">BMC, 2018</subfield><subfield code="g">37(2004), 4, Seite 661-664</subfield><subfield code="w">(DE-627)329975374</subfield><subfield code="w">(DE-600)2048380-6</subfield><subfield code="x">07176287</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:37</subfield><subfield code="g">year:2004</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:661-664</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/0716-9760</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/0717-6287</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">37</subfield><subfield code="j">2004</subfield><subfield code="e">4</subfield><subfield code="h">661-664</subfield></datafield></record></collection>
callnumber-first	Q - Science
author	OLE H. PETERSEN
spellingShingle	OLE H. PETERSEN misc QH301-705.5 misc Pancreatic Acinar Cell misc Intracellular Communication misc Ca2+ Signal Compartmentalization misc Ca2+ Release Mechanisms misc Local Ca2+ Signals misc Biology (General) Local and global Ca2+ signals: physiology and pathophysiology
authorStr	OLE H. PETERSEN
ppnlink_with_tag_str_mv	@@773@@(DE-627)329975374
format	electronic Article
delete_txt_mv	keep
author_role	aut
collection	DOAJ
remote_str	true
callnumber-label	QH301-705
illustrated	Not Illustrated
issn	07176287
topic_title	QH301-705.5 Local and global Ca2+ signals: physiology and pathophysiology Pancreatic Acinar Cell Intracellular Communication Ca2+ Signal Compartmentalization Ca2+ Release Mechanisms Local Ca2+ Signals
topic	misc QH301-705.5 misc Pancreatic Acinar Cell misc Intracellular Communication misc Ca2+ Signal Compartmentalization misc Ca2+ Release Mechanisms misc Local Ca2+ Signals misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Pancreatic Acinar Cell misc Intracellular Communication misc Ca2+ Signal Compartmentalization misc Ca2+ Release Mechanisms misc Local Ca2+ Signals misc Biology (General)
topic_browse	misc QH301-705.5 misc Pancreatic Acinar Cell misc Intracellular Communication misc Ca2+ Signal Compartmentalization misc Ca2+ Release Mechanisms misc Local Ca2+ Signals misc Biology (General)
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Biological Research
hierarchy_parent_id	329975374
hierarchy_top_title	Biological Research
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)329975374 (DE-600)2048380-6
title	Local and global Ca2+ signals: physiology and pathophysiology
ctrlnum	(DE-627)DOAJ05796694X (DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b
title_full	Local and global Ca2+ signals: physiology and pathophysiology
author_sort	OLE H. PETERSEN
journal	Biological Research
journalStr	Biological Research
callnumber-first-code	Q
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2004
contenttype_str_mv	txt
container_start_page	661
author_browse	OLE H. PETERSEN
container_volume	37
class	QH301-705.5
format_se	Elektronische Aufsätze
author-letter	OLE H. PETERSEN
title_sort	local and global ca2+ signals: physiology and pathophysiology
callnumber	QH301-705.5
title_auth	Local and global Ca2+ signals: physiology and pathophysiology
abstract	The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.
abstractGer	The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.
abstract_unstemmed	The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	4
title_short	Local and global Ca2+ signals: physiology and pathophysiology
url	https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023 https://doaj.org/toc/0716-9760 https://doaj.org/toc/0717-6287
remote_bool	true
ppnlink	329975374
callnumber-subject	QH - Natural History and Biology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
callnumber-a	QH301-705.5
up_date	2024-07-03T15:11:51.227Z
_version_	1803571179042111488
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ05796694X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308221932.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2004 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ05796694X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ986b7d3944ac41e69325e0d30b3a400b</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">OLE H. PETERSEN</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Local and global Ca2+ signals: physiology and pathophysiology</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2004</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pancreatic Acinar Cell</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intracellular Communication</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ca2+ Signal Compartmentalization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ca2+ Release Mechanisms</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Local Ca2+ Signals</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biology (General)</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biological Research</subfield><subfield code="d">BMC, 2018</subfield><subfield code="g">37(2004), 4, Seite 661-664</subfield><subfield code="w">(DE-627)329975374</subfield><subfield code="w">(DE-600)2048380-6</subfield><subfield code="x">07176287</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:37</subfield><subfield code="g">year:2004</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:661-664</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/986b7d3944ac41e69325e0d30b3a400b</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/0716-9760</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/0717-6287</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">37</subfield><subfield code="j">2004</subfield><subfield code="e">4</subfield><subfield code="h">661-664</subfield></datafield></record></collection>
score	7.4000893

Nicht das Richtige dabei?

Schreiben Sie uns!

Local and global Ca2+ signals: physiology and pathophysiology

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?