Differential challenges in salivary gland neoplasms

Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriat...
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Gespeichert in:

Autor*in:	Živković Nikola [verfasserIn] Kostić Miloš [verfasserIn] Cvetanović Ana [verfasserIn] Jovičić-Milentijević Maja [verfasserIn] Spasić Milan [verfasserIn] Petrović Milica [verfasserIn] Trajković Miloš [verfasserIn] Denčić Tijana [verfasserIn] Krtinić Dane [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	salivary gland neoplasm morphometry immunohistochemistry ki67

Übergeordnetes Werk:	In: Archives of Biological Sciences - University of Belgrade, University of Novi Sad, 2010, 73(2021), 1, Seite 65-72
Übergeordnetes Werk:	volume:73 ; year:2021 ; number:1 ; pages:65-72

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2298/ABS201201002Z

Katalog-ID:	DOAJ058015558

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author	Živković Nikola
spellingShingle	Živković Nikola misc QH301-705.5 misc salivary gland misc neoplasm misc morphometry misc immunohistochemistry misc ki67 misc Biology (General) Differential challenges in salivary gland neoplasms
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topic_title	QH301-705.5 Differential challenges in salivary gland neoplasms salivary gland neoplasm morphometry immunohistochemistry ki67
topic	misc QH301-705.5 misc salivary gland misc neoplasm misc morphometry misc immunohistochemistry misc ki67 misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc salivary gland misc neoplasm misc morphometry misc immunohistochemistry misc ki67 misc Biology (General)
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title	Differential challenges in salivary gland neoplasms
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title_full	Differential challenges in salivary gland neoplasms
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title_sort	differential challenges in salivary gland neoplasms
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title_auth	Differential challenges in salivary gland neoplasms
abstract	Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriate diagnosis. Our research included 120 tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, mucoepidermoid carcinoma, salivary duct carcinoma, polymorphous low-grade carcinoma and myoepithelial carcinoma. The aim of the study was to differentiate benign and malignant tumors based on the characteristics of nuclei. The expression of Ki67 and the morphometric nuclear parameters – area, perimeter, Feret diameter, integrated optical density, circularity, and roundness, were analyzed. It was observed that the Ki67 proliferative index was statistically significantly higher in malignant tumors (P<0.001). Adenoid cystic carcinoma exhibited the highest value, whereas the lowest value was exhibited in basal cell adenoma. Morphometric analysis showed statistically significantly increased values of integrated optical density (P<0.001) and nuclear size parameters (P<0.05) in malignant tumors. The determination of the Ki67 proliferative index and morphometric analysis of the integrated optical density and area can differentiate benign from malignant tumors with high precision. The presented values suggest the obtained results as cut-off values.
abstractGer	Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriate diagnosis. Our research included 120 tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, mucoepidermoid carcinoma, salivary duct carcinoma, polymorphous low-grade carcinoma and myoepithelial carcinoma. The aim of the study was to differentiate benign and malignant tumors based on the characteristics of nuclei. The expression of Ki67 and the morphometric nuclear parameters – area, perimeter, Feret diameter, integrated optical density, circularity, and roundness, were analyzed. It was observed that the Ki67 proliferative index was statistically significantly higher in malignant tumors (P<0.001). Adenoid cystic carcinoma exhibited the highest value, whereas the lowest value was exhibited in basal cell adenoma. Morphometric analysis showed statistically significantly increased values of integrated optical density (P<0.001) and nuclear size parameters (P<0.05) in malignant tumors. The determination of the Ki67 proliferative index and morphometric analysis of the integrated optical density and area can differentiate benign from malignant tumors with high precision. The presented values suggest the obtained results as cut-off values.
abstract_unstemmed	Salivary gland tumors are neoplasms characterized by a high level of pleomorphism and histological overlap. One tumor may contain several cell types; therefore, it is necessary to include immunohistochemical staining, as well as morphometric analysis of tumor cells as prerequisites for an appropriate diagnosis. Our research included 120 tumors, such as pleomorphic adenoma, Warthin tumor, basal cell adenoma, myoepithelioma, adenoid cystic carcinoma, mucoepidermoid carcinoma, salivary duct carcinoma, polymorphous low-grade carcinoma and myoepithelial carcinoma. The aim of the study was to differentiate benign and malignant tumors based on the characteristics of nuclei. The expression of Ki67 and the morphometric nuclear parameters – area, perimeter, Feret diameter, integrated optical density, circularity, and roundness, were analyzed. It was observed that the Ki67 proliferative index was statistically significantly higher in malignant tumors (P<0.001). Adenoid cystic carcinoma exhibited the highest value, whereas the lowest value was exhibited in basal cell adenoma. Morphometric analysis showed statistically significantly increased values of integrated optical density (P<0.001) and nuclear size parameters (P<0.05) in malignant tumors. The determination of the Ki67 proliferative index and morphometric analysis of the integrated optical density and area can differentiate benign from malignant tumors with high precision. The presented values suggest the obtained results as cut-off values.
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title_short	Differential challenges in salivary gland neoplasms
url	https://doi.org/10.2298/ABS201201002Z https://doaj.org/article/17ddc9f242ff4e778532637eec337903 http://www.doiserbia.nb.rs/img/doi/0354-4664/2021/0354-46642100002Z.pdf https://doaj.org/toc/0354-4664 https://doaj.org/toc/1821-4339
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up_date	2024-07-03T15:29:33.123Z
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Morphometric analysis showed statistically significantly increased values of integrated optical density (P<0.001) and nuclear size parameters (P<0.05) in malignant tumors. The determination of the Ki67 proliferative index and morphometric analysis of the integrated optical density and area can differentiate benign from malignant tumors with high precision. 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