Capture Efficiency of Magnetically Labeled Particles Traveling Through an Intracranial Aneurysm

Cell manipulation using external magnetic fields has been proposed to accelerate the neck reendothelization of saccular unruptured stented intracranial aneurysms. This work presents a computational fluid dynamics (CFD) model of a Saccular Brain Aneurysm that incorporates a helicoidal stent. An Euler...
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Autor*in:	Cardona M. [verfasserIn] Ramírez J. [verfasserIn] Benavides-Moran A.G. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	endothelization particle manipulation computational fluid dynamics magnetohydrodynamics

Übergeordnetes Werk:	In: International Journal of Applied Mechanics and Engineering - Sciendo, 2015, 26(2021), 1, Seite 65-75
Übergeordnetes Werk:	volume:26 ; year:2021 ; number:1 ; pages:65-75

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2478/ijame-2021-0004

Katalog-ID:	DOAJ058147853

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520			\|a Cell manipulation using external magnetic fields has been proposed to accelerate the neck reendothelization of saccular unruptured stented intracranial aneurysms. This work presents a computational fluid dynamics (CFD) model of a Saccular Brain Aneurysm that incorporates a helicoidal stent. An Eulerian-Lagrangian model implemented in ANSYS-Fluent is used to simulate the hemodynamics in the aneurysm. In silico studies have been conducted to describe the incidence of the magnetic field direction, frequency and amplitude on the blood hemodynamics and particle capture efficiency, when an external magnetic field is used to trap magnetically labeled particles traveling through the aneurysm. It is found that the magnetic field direction affects the particle concentration in the target region. Simulation results show that the highest particle capture efficiency is obtained with a 1T magnetic field amplitude in an open bore MRI scanner, when a permanent magnet is used.
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callnumber-first	T - Technology
author	Cardona M.
spellingShingle	Cardona M. misc TA349-359 misc endothelization misc particle manipulation misc computational fluid dynamics misc magnetohydrodynamics misc Mechanics of engineering. Applied mechanics Capture Efficiency of Magnetically Labeled Particles Traveling Through an Intracranial Aneurysm
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topic_title	TA349-359 Capture Efficiency of Magnetically Labeled Particles Traveling Through an Intracranial Aneurysm endothelization particle manipulation computational fluid dynamics magnetohydrodynamics
topic	misc TA349-359 misc endothelization misc particle manipulation misc computational fluid dynamics misc magnetohydrodynamics misc Mechanics of engineering. Applied mechanics
topic_unstemmed	misc TA349-359 misc endothelization misc particle manipulation misc computational fluid dynamics misc magnetohydrodynamics misc Mechanics of engineering. Applied mechanics
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title	Capture Efficiency of Magnetically Labeled Particles Traveling Through an Intracranial Aneurysm
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title_sort	capture efficiency of magnetically labeled particles traveling through an intracranial aneurysm
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title_auth	Capture Efficiency of Magnetically Labeled Particles Traveling Through an Intracranial Aneurysm
abstract	Cell manipulation using external magnetic fields has been proposed to accelerate the neck reendothelization of saccular unruptured stented intracranial aneurysms. This work presents a computational fluid dynamics (CFD) model of a Saccular Brain Aneurysm that incorporates a helicoidal stent. An Eulerian-Lagrangian model implemented in ANSYS-Fluent is used to simulate the hemodynamics in the aneurysm. In silico studies have been conducted to describe the incidence of the magnetic field direction, frequency and amplitude on the blood hemodynamics and particle capture efficiency, when an external magnetic field is used to trap magnetically labeled particles traveling through the aneurysm. It is found that the magnetic field direction affects the particle concentration in the target region. Simulation results show that the highest particle capture efficiency is obtained with a 1T magnetic field amplitude in an open bore MRI scanner, when a permanent magnet is used.
abstractGer	Cell manipulation using external magnetic fields has been proposed to accelerate the neck reendothelization of saccular unruptured stented intracranial aneurysms. This work presents a computational fluid dynamics (CFD) model of a Saccular Brain Aneurysm that incorporates a helicoidal stent. An Eulerian-Lagrangian model implemented in ANSYS-Fluent is used to simulate the hemodynamics in the aneurysm. In silico studies have been conducted to describe the incidence of the magnetic field direction, frequency and amplitude on the blood hemodynamics and particle capture efficiency, when an external magnetic field is used to trap magnetically labeled particles traveling through the aneurysm. It is found that the magnetic field direction affects the particle concentration in the target region. Simulation results show that the highest particle capture efficiency is obtained with a 1T magnetic field amplitude in an open bore MRI scanner, when a permanent magnet is used.
abstract_unstemmed	Cell manipulation using external magnetic fields has been proposed to accelerate the neck reendothelization of saccular unruptured stented intracranial aneurysms. This work presents a computational fluid dynamics (CFD) model of a Saccular Brain Aneurysm that incorporates a helicoidal stent. An Eulerian-Lagrangian model implemented in ANSYS-Fluent is used to simulate the hemodynamics in the aneurysm. In silico studies have been conducted to describe the incidence of the magnetic field direction, frequency and amplitude on the blood hemodynamics and particle capture efficiency, when an external magnetic field is used to trap magnetically labeled particles traveling through the aneurysm. It is found that the magnetic field direction affects the particle concentration in the target region. Simulation results show that the highest particle capture efficiency is obtained with a 1T magnetic field amplitude in an open bore MRI scanner, when a permanent magnet is used.
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title_short	Capture Efficiency of Magnetically Labeled Particles Traveling Through an Intracranial Aneurysm
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