Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study

Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate postt...
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Autor*in:	Ryo Yamada [verfasserIn] Satoshi Okumura [verfasserIn] Yuji Kono [verfasserIn] Akane Miyazaki [verfasserIn] Yudai Niwa [verfasserIn] Takehiro Ito [verfasserIn] Sayano Ueda [verfasserIn] Tomoya Ishiguro [verfasserIn] Masataka Yoshinaga [verfasserIn] Wakaya Fujiwara [verfasserIn] Mutsuharu Hayashi [verfasserIn] Yukio Ozaki [verfasserIn] Eiichi Saitoh [verfasserIn] Hideo Izawa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	microrna heart failure cardiac rehabilitation exercise

Übergeordnetes Werk:	In: Fujita Medical Journal - Fujita Medical Society, 2020, 7(2021), 3, Seite 76-82
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:3 ; pages:76-82

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.20407/fmj.2020-010

Katalog-ID:	DOAJ058181091

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520			\|a Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression.
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allfields	10.20407/fmj.2020-010 doi (DE-627)DOAJ058181091 (DE-599)DOAJ2613a3b002b843228798e409f9d4c4ad DE-627 ger DE-627 rakwb eng R5-920 Ryo Yamada verfasserin aut Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression. microrna heart failure cardiac rehabilitation exercise Medicine (General) Satoshi Okumura verfasserin aut Yuji Kono verfasserin aut Akane Miyazaki verfasserin aut Yudai Niwa verfasserin aut Takehiro Ito verfasserin aut Sayano Ueda verfasserin aut Tomoya Ishiguro verfasserin aut Masataka Yoshinaga verfasserin aut Wakaya Fujiwara verfasserin aut Mutsuharu Hayashi verfasserin aut Yukio Ozaki verfasserin aut Eiichi Saitoh verfasserin aut Hideo Izawa verfasserin aut In Fujita Medical Journal Fujita Medical Society, 2020 7(2021), 3, Seite 76-82 (DE-627)1692251066 21897255 nnns volume:7 year:2021 number:3 pages:76-82 https://doi.org/10.20407/fmj.2020-010 kostenfrei https://doaj.org/article/2613a3b002b843228798e409f9d4c4ad kostenfrei https://www.jstage.jst.go.jp/article/fmj/7/3/7_2020-010/_pdf/-char/en kostenfrei https://doaj.org/toc/2189-7247 Journal toc kostenfrei https://doaj.org/toc/2189-7255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 3 76-82
spelling	10.20407/fmj.2020-010 doi (DE-627)DOAJ058181091 (DE-599)DOAJ2613a3b002b843228798e409f9d4c4ad DE-627 ger DE-627 rakwb eng R5-920 Ryo Yamada verfasserin aut Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression. microrna heart failure cardiac rehabilitation exercise Medicine (General) Satoshi Okumura verfasserin aut Yuji Kono verfasserin aut Akane Miyazaki verfasserin aut Yudai Niwa verfasserin aut Takehiro Ito verfasserin aut Sayano Ueda verfasserin aut Tomoya Ishiguro verfasserin aut Masataka Yoshinaga verfasserin aut Wakaya Fujiwara verfasserin aut Mutsuharu Hayashi verfasserin aut Yukio Ozaki verfasserin aut Eiichi Saitoh verfasserin aut Hideo Izawa verfasserin aut In Fujita Medical Journal Fujita Medical Society, 2020 7(2021), 3, Seite 76-82 (DE-627)1692251066 21897255 nnns volume:7 year:2021 number:3 pages:76-82 https://doi.org/10.20407/fmj.2020-010 kostenfrei https://doaj.org/article/2613a3b002b843228798e409f9d4c4ad kostenfrei https://www.jstage.jst.go.jp/article/fmj/7/3/7_2020-010/_pdf/-char/en kostenfrei https://doaj.org/toc/2189-7247 Journal toc kostenfrei https://doaj.org/toc/2189-7255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 3 76-82
allfields_unstemmed	10.20407/fmj.2020-010 doi (DE-627)DOAJ058181091 (DE-599)DOAJ2613a3b002b843228798e409f9d4c4ad DE-627 ger DE-627 rakwb eng R5-920 Ryo Yamada verfasserin aut Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression. microrna heart failure cardiac rehabilitation exercise Medicine (General) Satoshi Okumura verfasserin aut Yuji Kono verfasserin aut Akane Miyazaki verfasserin aut Yudai Niwa verfasserin aut Takehiro Ito verfasserin aut Sayano Ueda verfasserin aut Tomoya Ishiguro verfasserin aut Masataka Yoshinaga verfasserin aut Wakaya Fujiwara verfasserin aut Mutsuharu Hayashi verfasserin aut Yukio Ozaki verfasserin aut Eiichi Saitoh verfasserin aut Hideo Izawa verfasserin aut In Fujita Medical Journal Fujita Medical Society, 2020 7(2021), 3, Seite 76-82 (DE-627)1692251066 21897255 nnns volume:7 year:2021 number:3 pages:76-82 https://doi.org/10.20407/fmj.2020-010 kostenfrei https://doaj.org/article/2613a3b002b843228798e409f9d4c4ad kostenfrei https://www.jstage.jst.go.jp/article/fmj/7/3/7_2020-010/_pdf/-char/en kostenfrei https://doaj.org/toc/2189-7247 Journal toc kostenfrei https://doaj.org/toc/2189-7255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 3 76-82
allfieldsGer	10.20407/fmj.2020-010 doi (DE-627)DOAJ058181091 (DE-599)DOAJ2613a3b002b843228798e409f9d4c4ad DE-627 ger DE-627 rakwb eng R5-920 Ryo Yamada verfasserin aut Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression. microrna heart failure cardiac rehabilitation exercise Medicine (General) Satoshi Okumura verfasserin aut Yuji Kono verfasserin aut Akane Miyazaki verfasserin aut Yudai Niwa verfasserin aut Takehiro Ito verfasserin aut Sayano Ueda verfasserin aut Tomoya Ishiguro verfasserin aut Masataka Yoshinaga verfasserin aut Wakaya Fujiwara verfasserin aut Mutsuharu Hayashi verfasserin aut Yukio Ozaki verfasserin aut Eiichi Saitoh verfasserin aut Hideo Izawa verfasserin aut In Fujita Medical Journal Fujita Medical Society, 2020 7(2021), 3, Seite 76-82 (DE-627)1692251066 21897255 nnns volume:7 year:2021 number:3 pages:76-82 https://doi.org/10.20407/fmj.2020-010 kostenfrei https://doaj.org/article/2613a3b002b843228798e409f9d4c4ad kostenfrei https://www.jstage.jst.go.jp/article/fmj/7/3/7_2020-010/_pdf/-char/en kostenfrei https://doaj.org/toc/2189-7247 Journal toc kostenfrei https://doaj.org/toc/2189-7255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 3 76-82
allfieldsSound	10.20407/fmj.2020-010 doi (DE-627)DOAJ058181091 (DE-599)DOAJ2613a3b002b843228798e409f9d4c4ad DE-627 ger DE-627 rakwb eng R5-920 Ryo Yamada verfasserin aut Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression. microrna heart failure cardiac rehabilitation exercise Medicine (General) Satoshi Okumura verfasserin aut Yuji Kono verfasserin aut Akane Miyazaki verfasserin aut Yudai Niwa verfasserin aut Takehiro Ito verfasserin aut Sayano Ueda verfasserin aut Tomoya Ishiguro verfasserin aut Masataka Yoshinaga verfasserin aut Wakaya Fujiwara verfasserin aut Mutsuharu Hayashi verfasserin aut Yukio Ozaki verfasserin aut Eiichi Saitoh verfasserin aut Hideo Izawa verfasserin aut In Fujita Medical Journal Fujita Medical Society, 2020 7(2021), 3, Seite 76-82 (DE-627)1692251066 21897255 nnns volume:7 year:2021 number:3 pages:76-82 https://doi.org/10.20407/fmj.2020-010 kostenfrei https://doaj.org/article/2613a3b002b843228798e409f9d4c4ad kostenfrei https://www.jstage.jst.go.jp/article/fmj/7/3/7_2020-010/_pdf/-char/en kostenfrei https://doaj.org/toc/2189-7247 Journal toc kostenfrei https://doaj.org/toc/2189-7255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 3 76-82
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authorswithroles_txt_mv	Ryo Yamada @@aut@@ Satoshi Okumura @@aut@@ Yuji Kono @@aut@@ Akane Miyazaki @@aut@@ Yudai Niwa @@aut@@ Takehiro Ito @@aut@@ Sayano Ueda @@aut@@ Tomoya Ishiguro @@aut@@ Masataka Yoshinaga @@aut@@ Wakaya Fujiwara @@aut@@ Mutsuharu Hayashi @@aut@@ Yukio Ozaki @@aut@@ Eiichi Saitoh @@aut@@ Hideo Izawa @@aut@@
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callnumber-first	R - Medicine
author	Ryo Yamada
spellingShingle	Ryo Yamada misc R5-920 misc microrna misc heart failure misc cardiac rehabilitation misc exercise misc Medicine (General) Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
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topic_title	R5-920 Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study microrna heart failure cardiac rehabilitation exercise
topic	misc R5-920 misc microrna misc heart failure misc cardiac rehabilitation misc exercise misc Medicine (General)
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title	Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
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title_full	Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
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author_browse	Ryo Yamada Satoshi Okumura Yuji Kono Akane Miyazaki Yudai Niwa Takehiro Ito Sayano Ueda Tomoya Ishiguro Masataka Yoshinaga Wakaya Fujiwara Mutsuharu Hayashi Yukio Ozaki Eiichi Saitoh Hideo Izawa
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title_sort	effect of cardiac rehabilitation on circulating microrna expression in heart failure: a preliminary study
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title_auth	Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
abstract	Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression.
abstractGer	Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression.
abstract_unstemmed	Objectives: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression.
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title_short	Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
url	https://doi.org/10.20407/fmj.2020-010 https://doaj.org/article/2613a3b002b843228798e409f9d4c4ad https://www.jstage.jst.go.jp/article/fmj/7/3/7_2020-010/_pdf/-char/en https://doaj.org/toc/2189-7247 https://doaj.org/toc/2189-7255
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author2	Satoshi Okumura Yuji Kono Akane Miyazaki Yudai Niwa Takehiro Ito Sayano Ueda Tomoya Ishiguro Masataka Yoshinaga Wakaya Fujiwara Mutsuharu Hayashi Yukio Ozaki Eiichi Saitoh Hideo Izawa
author2Str	Satoshi Okumura Yuji Kono Akane Miyazaki Yudai Niwa Takehiro Ito Sayano Ueda Tomoya Ishiguro Masataka Yoshinaga Wakaya Fujiwara Mutsuharu Hayashi Yukio Ozaki Eiichi Saitoh Hideo Izawa
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up_date	2024-07-03T16:28:56.022Z
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The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. Methods: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. Results: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. Conclusions: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. 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Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study

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