Prognostic Significance of the Number of Teeth in Patients with Colorectal Cancer
Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kyoichi Kihara [verfasserIn] Kazushi Hara [verfasserIn] Ken Sugezawa [verfasserIn] Chihiro Uejima [verfasserIn] Akimitsu Tanio [verfasserIn] Yoichiro Tada [verfasserIn] Manabu Yamamoto [verfasserIn] Hisashi Noma [verfasserIn] Naruro Tokuyasu [verfasserIn] Teruhisa Sakamoto [verfasserIn] Soichiro Honjo [verfasserIn] Yoshiyuki Fujiwara [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of the Anus, Rectum and Colon - The Japan Society of Coloproctology, 2019, 5(2021), 3, Seite 237-246 |
|---|---|
| Übergeordnetes Werk: |
volume:5 ; year:2021 ; number:3 ; pages:237-246 |
| Links: |
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| DOI / URN: |
10.23922/jarc.2020-091 |
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DOAJ058267506 |
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| 520 | |a Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. | ||
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10.23922/jarc.2020-091 doi (DE-627)DOAJ058267506 (DE-599)DOAJ6a8bfd11a70f48459334ca791d8d8fbc DE-627 ger DE-627 rakwb eng RC799-869 Kyoichi Kihara verfasserin aut Prognostic Significance of the Number of Teeth in Patients with Colorectal Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. tooth number colorectal cancer prognostic factor fusobacterium nucleatum periodontitis Diseases of the digestive system. Gastroenterology Kazushi Hara verfasserin aut Ken Sugezawa verfasserin aut Chihiro Uejima verfasserin aut Akimitsu Tanio verfasserin aut Yoichiro Tada verfasserin aut Manabu Yamamoto verfasserin aut Hisashi Noma verfasserin aut Naruro Tokuyasu verfasserin aut Teruhisa Sakamoto verfasserin aut Soichiro Honjo verfasserin aut Yoshiyuki Fujiwara verfasserin aut In Journal of the Anus, Rectum and Colon The Japan Society of Coloproctology, 2019 5(2021), 3, Seite 237-246 (DE-627)1698599595 24323853 nnns volume:5 year:2021 number:3 pages:237-246 https://doi.org/10.23922/jarc.2020-091 kostenfrei https://doaj.org/article/6a8bfd11a70f48459334ca791d8d8fbc kostenfrei https://www.jstage.jst.go.jp/article/jarc/5/3/5_2020-091/_pdf/-char/en kostenfrei https://doaj.org/toc/2432-3853 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021 3 237-246 |
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10.23922/jarc.2020-091 doi (DE-627)DOAJ058267506 (DE-599)DOAJ6a8bfd11a70f48459334ca791d8d8fbc DE-627 ger DE-627 rakwb eng RC799-869 Kyoichi Kihara verfasserin aut Prognostic Significance of the Number of Teeth in Patients with Colorectal Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. tooth number colorectal cancer prognostic factor fusobacterium nucleatum periodontitis Diseases of the digestive system. Gastroenterology Kazushi Hara verfasserin aut Ken Sugezawa verfasserin aut Chihiro Uejima verfasserin aut Akimitsu Tanio verfasserin aut Yoichiro Tada verfasserin aut Manabu Yamamoto verfasserin aut Hisashi Noma verfasserin aut Naruro Tokuyasu verfasserin aut Teruhisa Sakamoto verfasserin aut Soichiro Honjo verfasserin aut Yoshiyuki Fujiwara verfasserin aut In Journal of the Anus, Rectum and Colon The Japan Society of Coloproctology, 2019 5(2021), 3, Seite 237-246 (DE-627)1698599595 24323853 nnns volume:5 year:2021 number:3 pages:237-246 https://doi.org/10.23922/jarc.2020-091 kostenfrei https://doaj.org/article/6a8bfd11a70f48459334ca791d8d8fbc kostenfrei https://www.jstage.jst.go.jp/article/jarc/5/3/5_2020-091/_pdf/-char/en kostenfrei https://doaj.org/toc/2432-3853 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021 3 237-246 |
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10.23922/jarc.2020-091 doi (DE-627)DOAJ058267506 (DE-599)DOAJ6a8bfd11a70f48459334ca791d8d8fbc DE-627 ger DE-627 rakwb eng RC799-869 Kyoichi Kihara verfasserin aut Prognostic Significance of the Number of Teeth in Patients with Colorectal Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. tooth number colorectal cancer prognostic factor fusobacterium nucleatum periodontitis Diseases of the digestive system. Gastroenterology Kazushi Hara verfasserin aut Ken Sugezawa verfasserin aut Chihiro Uejima verfasserin aut Akimitsu Tanio verfasserin aut Yoichiro Tada verfasserin aut Manabu Yamamoto verfasserin aut Hisashi Noma verfasserin aut Naruro Tokuyasu verfasserin aut Teruhisa Sakamoto verfasserin aut Soichiro Honjo verfasserin aut Yoshiyuki Fujiwara verfasserin aut In Journal of the Anus, Rectum and Colon The Japan Society of Coloproctology, 2019 5(2021), 3, Seite 237-246 (DE-627)1698599595 24323853 nnns volume:5 year:2021 number:3 pages:237-246 https://doi.org/10.23922/jarc.2020-091 kostenfrei https://doaj.org/article/6a8bfd11a70f48459334ca791d8d8fbc kostenfrei https://www.jstage.jst.go.jp/article/jarc/5/3/5_2020-091/_pdf/-char/en kostenfrei https://doaj.org/toc/2432-3853 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021 3 237-246 |
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10.23922/jarc.2020-091 doi (DE-627)DOAJ058267506 (DE-599)DOAJ6a8bfd11a70f48459334ca791d8d8fbc DE-627 ger DE-627 rakwb eng RC799-869 Kyoichi Kihara verfasserin aut Prognostic Significance of the Number of Teeth in Patients with Colorectal Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. tooth number colorectal cancer prognostic factor fusobacterium nucleatum periodontitis Diseases of the digestive system. Gastroenterology Kazushi Hara verfasserin aut Ken Sugezawa verfasserin aut Chihiro Uejima verfasserin aut Akimitsu Tanio verfasserin aut Yoichiro Tada verfasserin aut Manabu Yamamoto verfasserin aut Hisashi Noma verfasserin aut Naruro Tokuyasu verfasserin aut Teruhisa Sakamoto verfasserin aut Soichiro Honjo verfasserin aut Yoshiyuki Fujiwara verfasserin aut In Journal of the Anus, Rectum and Colon The Japan Society of Coloproctology, 2019 5(2021), 3, Seite 237-246 (DE-627)1698599595 24323853 nnns volume:5 year:2021 number:3 pages:237-246 https://doi.org/10.23922/jarc.2020-091 kostenfrei https://doaj.org/article/6a8bfd11a70f48459334ca791d8d8fbc kostenfrei https://www.jstage.jst.go.jp/article/jarc/5/3/5_2020-091/_pdf/-char/en kostenfrei https://doaj.org/toc/2432-3853 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2021 3 237-246 |
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Prognostic Significance of the Number of Teeth in Patients with Colorectal Cancer |
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Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. |
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Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. |
| abstract_unstemmed |
Objectives: Fusobacterium nucleatum, which is the predominant subgingival microbial species found in chronic periodontitis, has been recently proposed as a risk factor for both the initiation and progression of colorectal cancer. We evaluated whether the number of teeth, which represents oral health, is a marker for the prognosis of patients with colorectal cancer. Methods: This retrospective single-center study recruited 179 patients who underwent primary colorectal cancer resection with curative intent between 2015 and 2017. The baseline characteristics and survival were analyzed according to the number of teeth observed in dental panoramic radiographs taken before surgical resection as a part of the perioperative surveillance for oral function and hygiene. Results: The median number of teeth was 20 (interquartile range: 6-25), including 28 patients with no teeth. Patients with 20 or more teeth had better overall survival (p = 0.002) and colorectal cancer-specific survival (p = 0.032) than those with less than 20 teeth. Multivariate analyses confirmed that the number of teeth was a significant prognostic factor for overall survival (p = 0.045) but not for colorectal cancer-specific survival (p = 0.258). We also took a propensity score-weighting approach using inverse probability weighting, and the p-values of the number of teeth were 0.032 for overall survival and 0.180 for colorectal cancer-specific survival. Conclusions: A low number of teeth, which can be easily and noninvasively assessed, has been a poor prognostic factor for overall survival in colorectal cancer patients who underwent surgery with curative intent. |
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Prognostic Significance of the Number of Teeth in Patients with Colorectal Cancer |
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https://doi.org/10.23922/jarc.2020-091 https://doaj.org/article/6a8bfd11a70f48459334ca791d8d8fbc https://www.jstage.jst.go.jp/article/jarc/5/3/5_2020-091/_pdf/-char/en https://doaj.org/toc/2432-3853 |
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Kazushi Hara Ken Sugezawa Chihiro Uejima Akimitsu Tanio Yoichiro Tada Manabu Yamamoto Hisashi Noma Naruro Tokuyasu Teruhisa Sakamoto Soichiro Honjo Yoshiyuki Fujiwara |
| author2Str |
Kazushi Hara Ken Sugezawa Chihiro Uejima Akimitsu Tanio Yoichiro Tada Manabu Yamamoto Hisashi Noma Naruro Tokuyasu Teruhisa Sakamoto Soichiro Honjo Yoshiyuki Fujiwara |
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2024-07-03T16:59:08.313Z |
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