Studies on the metabolic fate of n-3 polyunsaturated fatty acids

Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sacha Ferdinandusse [verfasserIn] Simone Denis [verfasserIn] Georges Dacremont [verfasserIn] Ronald J.A. Wanders [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Schlagwörter:	peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 44(2003), 10, Seite 1992-1997
Übergeordnetes Werk:	volume:44 ; year:2003 ; number:10 ; pages:1992-1997

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M300223-JLR200

Katalog-ID:	DOAJ058315608

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520			\|a Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids.
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allfields	10.1194/jlr.M300223-JLR200 doi (DE-627)DOAJ058315608 (DE-599)DOAJ72feac83440e4547ae31e41fe90e0637 DE-627 ger DE-627 rakwb eng QD415-436 Sacha Ferdinandusse verfasserin aut Studies on the metabolic fate of n-3 polyunsaturated fatty acids 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids. peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase Biochemistry Simone Denis verfasserin aut Georges Dacremont verfasserin aut Ronald J.A. Wanders verfasserin aut In Journal of Lipid Research Elsevier, 2021 44(2003), 10, Seite 1992-1997 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:44 year:2003 number:10 pages:1992-1997 https://doi.org/10.1194/jlr.M300223-JLR200 kostenfrei https://doaj.org/article/72feac83440e4547ae31e41fe90e0637 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520337172 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2003 10 1992-1997
spelling	10.1194/jlr.M300223-JLR200 doi (DE-627)DOAJ058315608 (DE-599)DOAJ72feac83440e4547ae31e41fe90e0637 DE-627 ger DE-627 rakwb eng QD415-436 Sacha Ferdinandusse verfasserin aut Studies on the metabolic fate of n-3 polyunsaturated fatty acids 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids. peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase Biochemistry Simone Denis verfasserin aut Georges Dacremont verfasserin aut Ronald J.A. Wanders verfasserin aut In Journal of Lipid Research Elsevier, 2021 44(2003), 10, Seite 1992-1997 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:44 year:2003 number:10 pages:1992-1997 https://doi.org/10.1194/jlr.M300223-JLR200 kostenfrei https://doaj.org/article/72feac83440e4547ae31e41fe90e0637 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520337172 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2003 10 1992-1997
allfields_unstemmed	10.1194/jlr.M300223-JLR200 doi (DE-627)DOAJ058315608 (DE-599)DOAJ72feac83440e4547ae31e41fe90e0637 DE-627 ger DE-627 rakwb eng QD415-436 Sacha Ferdinandusse verfasserin aut Studies on the metabolic fate of n-3 polyunsaturated fatty acids 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids. peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase Biochemistry Simone Denis verfasserin aut Georges Dacremont verfasserin aut Ronald J.A. Wanders verfasserin aut In Journal of Lipid Research Elsevier, 2021 44(2003), 10, Seite 1992-1997 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:44 year:2003 number:10 pages:1992-1997 https://doi.org/10.1194/jlr.M300223-JLR200 kostenfrei https://doaj.org/article/72feac83440e4547ae31e41fe90e0637 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520337172 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2003 10 1992-1997
allfieldsGer	10.1194/jlr.M300223-JLR200 doi (DE-627)DOAJ058315608 (DE-599)DOAJ72feac83440e4547ae31e41fe90e0637 DE-627 ger DE-627 rakwb eng QD415-436 Sacha Ferdinandusse verfasserin aut Studies on the metabolic fate of n-3 polyunsaturated fatty acids 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids. peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase Biochemistry Simone Denis verfasserin aut Georges Dacremont verfasserin aut Ronald J.A. Wanders verfasserin aut In Journal of Lipid Research Elsevier, 2021 44(2003), 10, Seite 1992-1997 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:44 year:2003 number:10 pages:1992-1997 https://doi.org/10.1194/jlr.M300223-JLR200 kostenfrei https://doaj.org/article/72feac83440e4547ae31e41fe90e0637 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520337172 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2003 10 1992-1997
allfieldsSound	10.1194/jlr.M300223-JLR200 doi (DE-627)DOAJ058315608 (DE-599)DOAJ72feac83440e4547ae31e41fe90e0637 DE-627 ger DE-627 rakwb eng QD415-436 Sacha Ferdinandusse verfasserin aut Studies on the metabolic fate of n-3 polyunsaturated fatty acids 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids. peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase Biochemistry Simone Denis verfasserin aut Georges Dacremont verfasserin aut Ronald J.A. Wanders verfasserin aut In Journal of Lipid Research Elsevier, 2021 44(2003), 10, Seite 1992-1997 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:44 year:2003 number:10 pages:1992-1997 https://doi.org/10.1194/jlr.M300223-JLR200 kostenfrei https://doaj.org/article/72feac83440e4547ae31e41fe90e0637 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520337172 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 44 2003 10 1992-1997
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source	In Journal of Lipid Research 44(2003), 10, Seite 1992-1997 volume:44 year:2003 number:10 pages:1992-1997
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topic_facet	peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase Biochemistry
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container_title	Journal of Lipid Research
authorswithroles_txt_mv	Sacha Ferdinandusse @@aut@@ Simone Denis @@aut@@ Georges Dacremont @@aut@@ Ronald J.A. Wanders @@aut@@
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callnumber-first	Q - Science
author	Sacha Ferdinandusse
spellingShingle	Sacha Ferdinandusse misc QD415-436 misc peroxisomes misc β-oxidation misc docosahexaenoic acid misc thioesterase misc acyl-CoA oxidase misc Biochemistry Studies on the metabolic fate of n-3 polyunsaturated fatty acids
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topic_title	QD415-436 Studies on the metabolic fate of n-3 polyunsaturated fatty acids peroxisomes β-oxidation docosahexaenoic acid thioesterase acyl-CoA oxidase
topic	misc QD415-436 misc peroxisomes misc β-oxidation misc docosahexaenoic acid misc thioesterase misc acyl-CoA oxidase misc Biochemistry
topic_unstemmed	misc QD415-436 misc peroxisomes misc β-oxidation misc docosahexaenoic acid misc thioesterase misc acyl-CoA oxidase misc Biochemistry
topic_browse	misc QD415-436 misc peroxisomes misc β-oxidation misc docosahexaenoic acid misc thioesterase misc acyl-CoA oxidase misc Biochemistry
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title	Studies on the metabolic fate of n-3 polyunsaturated fatty acids
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title_full	Studies on the metabolic fate of n-3 polyunsaturated fatty acids
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author_browse	Sacha Ferdinandusse Simone Denis Georges Dacremont Ronald J.A. Wanders
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title_sort	studies on the metabolic fate of n-3 polyunsaturated fatty acids
callnumber	QD415-436
title_auth	Studies on the metabolic fate of n-3 polyunsaturated fatty acids
abstract	Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids.
abstractGer	Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids.
abstract_unstemmed	Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporated 7 times faster into different lipid classes than was [1-14C]24:6n-3. When determining the peroxisomal acyl-CoA oxidase activity, similar specific activities for C22:6(n-3)-CoA and C24:6(n-3)-CoA were found in mouse kidney peroxisomes. Thioesterase activity was measured for both substrates in mouse kidney peroxisomes as well as mitochondria, and C22:6(n-3)-CoA was hydrolyzed 1.7 times faster than C24:6(n-3)-CoA.These results imply that the preferred metabolic fate of C24:6(n-3)-CoA, after its synthesis in the endoplasmic reticulum (ER), is to move to the peroxisome, where it is β-oxidized, producing C22:6(n-3)-CoA. This DHA-CoA then preferentially moves back, probably as free fatty acid, to the ER, where it is incorporated into membrane lipids.
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title_short	Studies on the metabolic fate of n-3 polyunsaturated fatty acids
url	https://doi.org/10.1194/jlr.M300223-JLR200 https://doaj.org/article/72feac83440e4547ae31e41fe90e0637 http://www.sciencedirect.com/science/article/pii/S0022227520337172 https://doaj.org/toc/0022-2275
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author2	Simone Denis Georges Dacremont Ronald J.A. Wanders
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up_date	2024-07-03T17:16:46.289Z
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Studies on the metabolic fate of n-3 polyunsaturated fatty acids

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