Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit diffe...
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Autor*in:	Ružena Čižmáriková [verfasserIn] Jindra Valentová [verfasserIn] Renáta Horáková [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	2-agonists stereoisomers pharmacological activity stereoselective analysis stereoselective synthesis

Übergeordnetes Werk:	In: Open Chemistry - De Gruyter, 2015, 18(2020), 1, Seite 628-647
Übergeordnetes Werk:	volume:18 ; year:2020 ; number:1 ; pages:628-647

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1515/chem-2020-0056

Katalog-ID:	DOAJ058317988

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language	English
source	In Open Chemistry 18(2020), 1, Seite 628-647 volume:18 year:2020 number:1 pages:628-647
sourceStr	In Open Chemistry 18(2020), 1, Seite 628-647 volume:18 year:2020 number:1 pages:628-647
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topic_facet	2-agonists stereoisomers pharmacological activity stereoselective analysis stereoselective synthesis Chemistry
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container_title	Open Chemistry
authorswithroles_txt_mv	Ružena Čižmáriková @@aut@@ Jindra Valentová @@aut@@ Renáta Horáková @@aut@@
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spellingShingle	Ružena Čižmáriková misc QD1-999 misc 2-agonists misc stereoisomers misc pharmacological activity misc stereoselective analysis misc stereoselective synthesis misc Chemistry Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis
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topic_title	QD1-999 Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis 2-agonists stereoisomers pharmacological activity stereoselective analysis stereoselective synthesis
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title	Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis
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title_sort	chirality of β2-agonists. an overview of pharmacological activity, stereoselective analysis, and synthesis
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title_auth	Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis
abstract	β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit different pharmacological properties. In terms of bronchodilatory activity, (R)-enantiomers showed higher activity. The investigation of stereoselectivity in action and disposition of chiral drugs together with the preparation of pure enantiomer drugs calls for efficient stereoselective analytical methods. The overview focuses on the stereoselectivity in pharmacodynamics and pharmacokinetics of β2-agonists and summarizes the stereoselective analytical methods for the enantioseparation of racemic beta-agonists (HPLC, LC-MS, GC, TLC, CE). Some methods of the stereoselective synthesis for β2-agonists preparation are also presented.
abstractGer	β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit different pharmacological properties. In terms of bronchodilatory activity, (R)-enantiomers showed higher activity. The investigation of stereoselectivity in action and disposition of chiral drugs together with the preparation of pure enantiomer drugs calls for efficient stereoselective analytical methods. The overview focuses on the stereoselectivity in pharmacodynamics and pharmacokinetics of β2-agonists and summarizes the stereoselective analytical methods for the enantioseparation of racemic beta-agonists (HPLC, LC-MS, GC, TLC, CE). Some methods of the stereoselective synthesis for β2-agonists preparation are also presented.
abstract_unstemmed	β2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit different pharmacological properties. In terms of bronchodilatory activity, (R)-enantiomers showed higher activity. The investigation of stereoselectivity in action and disposition of chiral drugs together with the preparation of pure enantiomer drugs calls for efficient stereoselective analytical methods. The overview focuses on the stereoselectivity in pharmacodynamics and pharmacokinetics of β2-agonists and summarizes the stereoselective analytical methods for the enantioseparation of racemic beta-agonists (HPLC, LC-MS, GC, TLC, CE). Some methods of the stereoselective synthesis for β2-agonists preparation are also presented.
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title_short	Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis
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Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

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