Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases

<strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Saverio Capodiferro [verfasserIn] Giuseppe Ingravallo [verfasserIn] Luisa Limongelli [verfasserIn] Mauro Giuseppe Mastropasqua [verfasserIn] Angela Tempesta [verfasserIn] Gianfranco Favia [verfasserIn] Eugenio Maiorano [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	salivary glands minor salivary glands salivary gland carcinoma mucoepidermoid carcinoma in situ carcinoma intra-cystic carcinoma

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 9(2020), 4, p 1157
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:4, p 1157

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm9041157

Katalog-ID:	DOAJ058460659

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allfields	10.3390/jcm9041157 doi (DE-627)DOAJ058460659 (DE-599)DOAJ3a5302e255004dacbcb633aa03e3c6ec DE-627 ger DE-627 rakwb eng Saverio Capodiferro verfasserin aut Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize. salivary glands minor salivary glands salivary gland carcinoma mucoepidermoid carcinoma in situ carcinoma intra-cystic carcinoma Medicine R Giuseppe Ingravallo verfasserin aut Luisa Limongelli verfasserin aut Mauro Giuseppe Mastropasqua verfasserin aut Angela Tempesta verfasserin aut Gianfranco Favia verfasserin aut Eugenio Maiorano verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 4, p 1157 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:4, p 1157 https://doi.org/10.3390/jcm9041157 kostenfrei https://doaj.org/article/3a5302e255004dacbcb633aa03e3c6ec kostenfrei https://www.mdpi.com/2077-0383/9/4/1157 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 4, p 1157
spelling	10.3390/jcm9041157 doi (DE-627)DOAJ058460659 (DE-599)DOAJ3a5302e255004dacbcb633aa03e3c6ec DE-627 ger DE-627 rakwb eng Saverio Capodiferro verfasserin aut Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize. salivary glands minor salivary glands salivary gland carcinoma mucoepidermoid carcinoma in situ carcinoma intra-cystic carcinoma Medicine R Giuseppe Ingravallo verfasserin aut Luisa Limongelli verfasserin aut Mauro Giuseppe Mastropasqua verfasserin aut Angela Tempesta verfasserin aut Gianfranco Favia verfasserin aut Eugenio Maiorano verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 4, p 1157 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:4, p 1157 https://doi.org/10.3390/jcm9041157 kostenfrei https://doaj.org/article/3a5302e255004dacbcb633aa03e3c6ec kostenfrei https://www.mdpi.com/2077-0383/9/4/1157 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 4, p 1157
allfields_unstemmed	10.3390/jcm9041157 doi (DE-627)DOAJ058460659 (DE-599)DOAJ3a5302e255004dacbcb633aa03e3c6ec DE-627 ger DE-627 rakwb eng Saverio Capodiferro verfasserin aut Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize. salivary glands minor salivary glands salivary gland carcinoma mucoepidermoid carcinoma in situ carcinoma intra-cystic carcinoma Medicine R Giuseppe Ingravallo verfasserin aut Luisa Limongelli verfasserin aut Mauro Giuseppe Mastropasqua verfasserin aut Angela Tempesta verfasserin aut Gianfranco Favia verfasserin aut Eugenio Maiorano verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 4, p 1157 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:4, p 1157 https://doi.org/10.3390/jcm9041157 kostenfrei https://doaj.org/article/3a5302e255004dacbcb633aa03e3c6ec kostenfrei https://www.mdpi.com/2077-0383/9/4/1157 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 4, p 1157
allfieldsGer	10.3390/jcm9041157 doi (DE-627)DOAJ058460659 (DE-599)DOAJ3a5302e255004dacbcb633aa03e3c6ec DE-627 ger DE-627 rakwb eng Saverio Capodiferro verfasserin aut Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize. salivary glands minor salivary glands salivary gland carcinoma mucoepidermoid carcinoma in situ carcinoma intra-cystic carcinoma Medicine R Giuseppe Ingravallo verfasserin aut Luisa Limongelli verfasserin aut Mauro Giuseppe Mastropasqua verfasserin aut Angela Tempesta verfasserin aut Gianfranco Favia verfasserin aut Eugenio Maiorano verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 4, p 1157 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:4, p 1157 https://doi.org/10.3390/jcm9041157 kostenfrei https://doaj.org/article/3a5302e255004dacbcb633aa03e3c6ec kostenfrei https://www.mdpi.com/2077-0383/9/4/1157 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 4, p 1157
allfieldsSound	10.3390/jcm9041157 doi (DE-627)DOAJ058460659 (DE-599)DOAJ3a5302e255004dacbcb633aa03e3c6ec DE-627 ger DE-627 rakwb eng Saverio Capodiferro verfasserin aut Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize. salivary glands minor salivary glands salivary gland carcinoma mucoepidermoid carcinoma in situ carcinoma intra-cystic carcinoma Medicine R Giuseppe Ingravallo verfasserin aut Luisa Limongelli verfasserin aut Mauro Giuseppe Mastropasqua verfasserin aut Angela Tempesta verfasserin aut Gianfranco Favia verfasserin aut Eugenio Maiorano verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 4, p 1157 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:4, p 1157 https://doi.org/10.3390/jcm9041157 kostenfrei https://doaj.org/article/3a5302e255004dacbcb633aa03e3c6ec kostenfrei https://www.mdpi.com/2077-0383/9/4/1157 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 4, p 1157
language	English
source	In Journal of Clinical Medicine 9(2020), 4, p 1157 volume:9 year:2020 number:4, p 1157
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authorswithroles_txt_mv	Saverio Capodiferro @@aut@@ Giuseppe Ingravallo @@aut@@ Luisa Limongelli @@aut@@ Mauro Giuseppe Mastropasqua @@aut@@ Angela Tempesta @@aut@@ Gianfranco Favia @@aut@@ Eugenio Maiorano @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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author	Saverio Capodiferro
spellingShingle	Saverio Capodiferro misc salivary glands misc minor salivary glands misc salivary gland carcinoma misc mucoepidermoid carcinoma misc in situ carcinoma misc intra-cystic carcinoma misc Medicine misc R Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases
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issn	20770383
topic_title	Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases salivary glands minor salivary glands salivary gland carcinoma mucoepidermoid carcinoma in situ carcinoma intra-cystic carcinoma
topic	misc salivary glands misc minor salivary glands misc salivary gland carcinoma misc mucoepidermoid carcinoma misc in situ carcinoma misc intra-cystic carcinoma misc Medicine misc R
topic_unstemmed	misc salivary glands misc minor salivary glands misc salivary gland carcinoma misc mucoepidermoid carcinoma misc in situ carcinoma misc intra-cystic carcinoma misc Medicine misc R
topic_browse	misc salivary glands misc minor salivary glands misc salivary gland carcinoma misc mucoepidermoid carcinoma misc in situ carcinoma misc intra-cystic carcinoma misc Medicine misc R
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title	Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases
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title_full	Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases
author_sort	Saverio Capodiferro
journal	Journal of Clinical Medicine
journalStr	Journal of Clinical Medicine
lang_code	eng
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author_browse	Saverio Capodiferro Giuseppe Ingravallo Luisa Limongelli Mauro Giuseppe Mastropasqua Angela Tempesta Gianfranco Favia Eugenio Maiorano
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author-letter	Saverio Capodiferro
doi_str_mv	10.3390/jcm9041157
author2-role	verfasserin
title_sort	intra-cystic (in situ) mucoepidermoid carcinoma: a clinico-pathological study of 14 cases
title_auth	Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases
abstract	<strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize.
abstractGer	<strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize.
abstract_unstemmed	<strong<Aims</strong<: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. <strong<Materials and methods</strong<: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. <strong<Results</strong<: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of five years. The neoplasms were located in the hard palate (nine cases), the soft palate (two), the cheek (two) and the retromolar trigone (one). In all instances, histological examination revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS, Mucicarmine and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue, and no solid areas or infiltrating tumor cell clusters were detected. Conservative surgical resection was performed in all cases, and no recurrences or nodal metastases were observed during follow up. <strong<Conclusions:</strong< Mucoepidermoid carcinomas showing prominent (<20%) intra-cystic proliferation currently are considered low-grade tumors. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic component and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues and metastasize.
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title_short	Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases
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author2	Giuseppe Ingravallo Luisa Limongelli Mauro Giuseppe Mastropasqua Angela Tempesta Gianfranco Favia Eugenio Maiorano
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up_date	2024-07-03T18:07:43.191Z
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