Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease
Abstract Given the chronic inflammatory nature of Parkinson’s disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in t...
Ausführliche Beschreibung
Autor*in: |
Pingping Wang [verfasserIn] Lifen Yao [verfasserIn] Meng Luo [verfasserIn] Wenyang Zhou [verfasserIn] Xiyun Jin [verfasserIn] Zhaochun Xu [verfasserIn] Shi Yan [verfasserIn] Yiqun Li [verfasserIn] Chang Xu [verfasserIn] Rui Cheng [verfasserIn] Yan Huang [verfasserIn] Xiaoyu Lin [verfasserIn] Kexin Ma [verfasserIn] Huimin Cao [verfasserIn] Hongxin Liu [verfasserIn] Guangfu Xue [verfasserIn] Fang Han [verfasserIn] Huan Nie [verfasserIn] Qinghua Jiang [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Cell Discovery - Nature Publishing Group, 2015, 7(2021), 1, Seite 16 |
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Übergeordnetes Werk: |
volume:7 ; year:2021 ; number:1 ; pages:16 |
Links: |
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DOI / URN: |
10.1038/s41421-021-00280-3 |
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Katalog-ID: |
DOAJ058514325 |
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10.1038/s41421-021-00280-3 doi (DE-627)DOAJ058514325 (DE-599)DOAJe479b76060ba44c7bf9bf381d3313824 DE-627 ger DE-627 rakwb eng QH573-671 Pingping Wang verfasserin aut Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Given the chronic inflammatory nature of Parkinson’s disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of PD. Combined expression and TCR-based lineage tracking, we discovered a large population of CD8+ T cells showing continuous progression from central memory to terminal effector T cells in PD patients. Additionally, we identified a group of cytotoxic CD4+ T cells (CD4 CTLs) remarkably expanded in PD patients, which derived from Th1 cells by TCR-based fate decision. Finally, we screened putative TCR–antigen pairs that existed in both blood and cerebrospinal fluid of PD patients to provide potential evidence for peripheral T cells to participate in neuronal degeneration. Our study provides valuable insights and rich resources for understanding the adaptive immune response in PD. Cytology Lifen Yao verfasserin aut Meng Luo verfasserin aut Wenyang Zhou verfasserin aut Xiyun Jin verfasserin aut Zhaochun Xu verfasserin aut Shi Yan verfasserin aut Yiqun Li verfasserin aut Chang Xu verfasserin aut Rui Cheng verfasserin aut Yan Huang verfasserin aut Xiaoyu Lin verfasserin aut Kexin Ma verfasserin aut Huimin Cao verfasserin aut Hongxin Liu verfasserin aut Guangfu Xue verfasserin aut Fang Han verfasserin aut Huan Nie verfasserin aut Qinghua Jiang verfasserin aut In Cell Discovery Nature Publishing Group, 2015 7(2021), 1, Seite 16 (DE-627)843856637 (DE-600)2842548-0 20565968 nnns volume:7 year:2021 number:1 pages:16 https://doi.org/10.1038/s41421-021-00280-3 kostenfrei https://doaj.org/article/e479b76060ba44c7bf9bf381d3313824 kostenfrei https://doi.org/10.1038/s41421-021-00280-3 kostenfrei https://doaj.org/toc/2056-5968 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 16 |
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Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease |
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Abstract Given the chronic inflammatory nature of Parkinson’s disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of PD. Combined expression and TCR-based lineage tracking, we discovered a large population of CD8+ T cells showing continuous progression from central memory to terminal effector T cells in PD patients. Additionally, we identified a group of cytotoxic CD4+ T cells (CD4 CTLs) remarkably expanded in PD patients, which derived from Th1 cells by TCR-based fate decision. Finally, we screened putative TCR–antigen pairs that existed in both blood and cerebrospinal fluid of PD patients to provide potential evidence for peripheral T cells to participate in neuronal degeneration. Our study provides valuable insights and rich resources for understanding the adaptive immune response in PD. |
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Abstract Given the chronic inflammatory nature of Parkinson’s disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of PD. Combined expression and TCR-based lineage tracking, we discovered a large population of CD8+ T cells showing continuous progression from central memory to terminal effector T cells in PD patients. Additionally, we identified a group of cytotoxic CD4+ T cells (CD4 CTLs) remarkably expanded in PD patients, which derived from Th1 cells by TCR-based fate decision. Finally, we screened putative TCR–antigen pairs that existed in both blood and cerebrospinal fluid of PD patients to provide potential evidence for peripheral T cells to participate in neuronal degeneration. Our study provides valuable insights and rich resources for understanding the adaptive immune response in PD. |
abstract_unstemmed |
Abstract Given the chronic inflammatory nature of Parkinson’s disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of PD. Combined expression and TCR-based lineage tracking, we discovered a large population of CD8+ T cells showing continuous progression from central memory to terminal effector T cells in PD patients. Additionally, we identified a group of cytotoxic CD4+ T cells (CD4 CTLs) remarkably expanded in PD patients, which derived from Th1 cells by TCR-based fate decision. Finally, we screened putative TCR–antigen pairs that existed in both blood and cerebrospinal fluid of PD patients to provide potential evidence for peripheral T cells to participate in neuronal degeneration. Our study provides valuable insights and rich resources for understanding the adaptive immune response in PD. |
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