Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer

The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed...
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Autor*in:	Wanting Shao [verfasserIn] Christina Kuhn [verfasserIn] Doris Mayr [verfasserIn] Nina Ditsch [verfasserIn] Magdalena Kailuweit [verfasserIn] Verena Wolf [verfasserIn] Nadia Harbeck [verfasserIn] Sven Mahner [verfasserIn] Udo Jeschke [verfasserIn] Vincent Cavaillès [verfasserIn] Sophie Sixou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	thyroid hormone receptor beta 1 subcellular localization overall survival breast cancer

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2020), 1, p 330
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:1, p 330

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms21010330

Katalog-ID:	DOAJ058524827

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520			\|a The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups.
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allfields	10.3390/ijms21010330 doi (DE-627)DOAJ058524827 (DE-599)DOAJb8ef80970fcf4f21b897f2a490837eea DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Wanting Shao verfasserin aut Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups. thyroid hormone receptor beta 1 subcellular localization overall survival breast cancer Biology (General) Chemistry Christina Kuhn verfasserin aut Doris Mayr verfasserin aut Nina Ditsch verfasserin aut Magdalena Kailuweit verfasserin aut Verena Wolf verfasserin aut Nadia Harbeck verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut Sophie Sixou verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 1, p 330 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:1, p 330 https://doi.org/10.3390/ijms21010330 kostenfrei https://doaj.org/article/b8ef80970fcf4f21b897f2a490837eea kostenfrei https://www.mdpi.com/1422-0067/21/1/330 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1, p 330
spelling	10.3390/ijms21010330 doi (DE-627)DOAJ058524827 (DE-599)DOAJb8ef80970fcf4f21b897f2a490837eea DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Wanting Shao verfasserin aut Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups. thyroid hormone receptor beta 1 subcellular localization overall survival breast cancer Biology (General) Chemistry Christina Kuhn verfasserin aut Doris Mayr verfasserin aut Nina Ditsch verfasserin aut Magdalena Kailuweit verfasserin aut Verena Wolf verfasserin aut Nadia Harbeck verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut Sophie Sixou verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 1, p 330 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:1, p 330 https://doi.org/10.3390/ijms21010330 kostenfrei https://doaj.org/article/b8ef80970fcf4f21b897f2a490837eea kostenfrei https://www.mdpi.com/1422-0067/21/1/330 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1, p 330
allfields_unstemmed	10.3390/ijms21010330 doi (DE-627)DOAJ058524827 (DE-599)DOAJb8ef80970fcf4f21b897f2a490837eea DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Wanting Shao verfasserin aut Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups. thyroid hormone receptor beta 1 subcellular localization overall survival breast cancer Biology (General) Chemistry Christina Kuhn verfasserin aut Doris Mayr verfasserin aut Nina Ditsch verfasserin aut Magdalena Kailuweit verfasserin aut Verena Wolf verfasserin aut Nadia Harbeck verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut Sophie Sixou verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 1, p 330 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:1, p 330 https://doi.org/10.3390/ijms21010330 kostenfrei https://doaj.org/article/b8ef80970fcf4f21b897f2a490837eea kostenfrei https://www.mdpi.com/1422-0067/21/1/330 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1, p 330
allfieldsGer	10.3390/ijms21010330 doi (DE-627)DOAJ058524827 (DE-599)DOAJb8ef80970fcf4f21b897f2a490837eea DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Wanting Shao verfasserin aut Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups. thyroid hormone receptor beta 1 subcellular localization overall survival breast cancer Biology (General) Chemistry Christina Kuhn verfasserin aut Doris Mayr verfasserin aut Nina Ditsch verfasserin aut Magdalena Kailuweit verfasserin aut Verena Wolf verfasserin aut Nadia Harbeck verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut Sophie Sixou verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 1, p 330 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:1, p 330 https://doi.org/10.3390/ijms21010330 kostenfrei https://doaj.org/article/b8ef80970fcf4f21b897f2a490837eea kostenfrei https://www.mdpi.com/1422-0067/21/1/330 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1, p 330
allfieldsSound	10.3390/ijms21010330 doi (DE-627)DOAJ058524827 (DE-599)DOAJb8ef80970fcf4f21b897f2a490837eea DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Wanting Shao verfasserin aut Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups. thyroid hormone receptor beta 1 subcellular localization overall survival breast cancer Biology (General) Chemistry Christina Kuhn verfasserin aut Doris Mayr verfasserin aut Nina Ditsch verfasserin aut Magdalena Kailuweit verfasserin aut Verena Wolf verfasserin aut Nadia Harbeck verfasserin aut Sven Mahner verfasserin aut Udo Jeschke verfasserin aut Vincent Cavaillès verfasserin aut Sophie Sixou verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 1, p 330 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:1, p 330 https://doi.org/10.3390/ijms21010330 kostenfrei https://doaj.org/article/b8ef80970fcf4f21b897f2a490837eea kostenfrei https://www.mdpi.com/1422-0067/21/1/330 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1, p 330
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callnumber-first	Q - Science
author	Wanting Shao
spellingShingle	Wanting Shao misc QH301-705.5 misc QD1-999 misc thyroid hormone receptor beta 1 misc subcellular localization misc overall survival misc breast cancer misc Biology (General) misc Chemistry Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer
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topic_title	QH301-705.5 QD1-999 Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer thyroid hormone receptor beta 1 subcellular localization overall survival breast cancer
topic	misc QH301-705.5 misc QD1-999 misc thyroid hormone receptor beta 1 misc subcellular localization misc overall survival misc breast cancer misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc thyroid hormone receptor beta 1 misc subcellular localization misc overall survival misc breast cancer misc Biology (General) misc Chemistry
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title	Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer
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title_full	Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer
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title_sort	cytoplasmic and nuclear forms of thyroid hormone receptor β1 are inversely associated with survival in primary breast cancer
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title_auth	Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer
abstract	The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups.
abstractGer	The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups.
abstract_unstemmed	The aim of this study was to investigate the expression of thyroid hormone receptor β1 (THRβ1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THRβ1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THRβ1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THRβ1 was correlated with favourable survival (<i<p</i< = 0.015), whereas nuclear THRβ1 had a statistically significant correlation with poor outcome (<i<p</i< = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THRβ1 appeared to be independent markers either for poor (<i<p</i< = 0.0004) or for good (<i<p</i< = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THRβ1 may play an important role in oncogenesis. Moreover, the expression of nuclear THRβ1 is a negative outcome marker, which may help to identify high-risk BC subgroups.
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title_short	Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer
url	https://doi.org/10.3390/ijms21010330 https://doaj.org/article/b8ef80970fcf4f21b897f2a490837eea https://www.mdpi.com/1422-0067/21/1/330 https://doaj.org/toc/1422-0067
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Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer

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