Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue

Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of TRL by WAT. Following the ingestion of a 13C-trio...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Simon Bissonnette [verfasserIn] Huda Salem [verfasserIn] Hanny Wassef [verfasserIn] Nathalie Saint-Pierre [verfasserIn] Annie Tardif [verfasserIn] Alexis Baass [verfasserIn] Robert Dufour [verfasserIn] May Faraj [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	dyslipidemia hyperapoB apolipoprotein B48 apolipoprotein B100 dietary triglyceride clearance

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 54(2013), 5, Seite 1466-1476
Übergeordnetes Werk:	volume:54 ; year:2013 ; number:5 ; pages:1466-1476

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.P023176

Katalog-ID:	DOAJ058542264

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520			\|a Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of TRL by WAT. Following the ingestion of a 13C-triolein-labeled high-fat meal, obese women with high plasma apoB (< median 0.93 g/l, N = 11, < 98% as IDL/LDL) had delayed clearance of postprandial 13C-triglyceride and 13C-NEFA over 6 h compared with controls. AUC6 h of plasma 13C-triglyceride and 13C-NEFA correlated with plasma apoB but not with LDL diameter or adipocyte area. There was no group difference in 13C-triolein oxidation rate, which suggests lower 13C-NEFA storage in peripheral tissue in women with high apoB. Ex vivo/in vitro plasma apoB correlated negatively with WAT 3H-lipid following a 4 h incubation of women舗s WAT with synthetic 3H-triolein-TRL. LDL-differentiated 3T3-L1 adipocytes had lower 3H-TRL hydrolysis and 3H-NEFA storage. Treatment of women舗s WAT with their own LDL decreased 3H-TRL hydrolysis and 3H-NEFA uptake. Finally, LDL, although not an LPL substrate, reduced LPL-mediated 3H-TRL hydrolysis as did VLDL and HDL. Exposure to LDL decreases TRL clearance by human WAT ex vivo. This may promote production of apoB-lipoproteins and hypertriglyceridemia through a positive-feedback mechanism in vivo.
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authorswithroles_txt_mv	Simon Bissonnette @@aut@@ Huda Salem @@aut@@ Hanny Wassef @@aut@@ Nathalie Saint-Pierre @@aut@@ Annie Tardif @@aut@@ Alexis Baass @@aut@@ Robert Dufour @@aut@@ May Faraj @@aut@@
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callnumber-first	Q - Science
author	Simon Bissonnette
spellingShingle	Simon Bissonnette misc QD415-436 misc dyslipidemia misc hyperapoB misc apolipoprotein B48 misc apolipoprotein B100 misc dietary triglyceride clearance misc Biochemistry Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue
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topic_title	QD415-436 Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue dyslipidemia hyperapoB apolipoprotein B48 apolipoprotein B100 dietary triglyceride clearance
topic	misc QD415-436 misc dyslipidemia misc hyperapoB misc apolipoprotein B48 misc apolipoprotein B100 misc dietary triglyceride clearance misc Biochemistry
topic_unstemmed	misc QD415-436 misc dyslipidemia misc hyperapoB misc apolipoprotein B48 misc apolipoprotein B100 misc dietary triglyceride clearance misc Biochemistry
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title	Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue
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title_full	Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue
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author_browse	Simon Bissonnette Huda Salem Hanny Wassef Nathalie Saint-Pierre Annie Tardif Alexis Baass Robert Dufour May Faraj
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title_sort	low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue
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title_auth	Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue
abstract	Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of TRL by WAT. Following the ingestion of a 13C-triolein-labeled high-fat meal, obese women with high plasma apoB (< median 0.93 g/l, N = 11, < 98% as IDL/LDL) had delayed clearance of postprandial 13C-triglyceride and 13C-NEFA over 6 h compared with controls. AUC6 h of plasma 13C-triglyceride and 13C-NEFA correlated with plasma apoB but not with LDL diameter or adipocyte area. There was no group difference in 13C-triolein oxidation rate, which suggests lower 13C-NEFA storage in peripheral tissue in women with high apoB. Ex vivo/in vitro plasma apoB correlated negatively with WAT 3H-lipid following a 4 h incubation of women舗s WAT with synthetic 3H-triolein-TRL. LDL-differentiated 3T3-L1 adipocytes had lower 3H-TRL hydrolysis and 3H-NEFA storage. Treatment of women舗s WAT with their own LDL decreased 3H-TRL hydrolysis and 3H-NEFA uptake. Finally, LDL, although not an LPL substrate, reduced LPL-mediated 3H-TRL hydrolysis as did VLDL and HDL. Exposure to LDL decreases TRL clearance by human WAT ex vivo. This may promote production of apoB-lipoproteins and hypertriglyceridemia through a positive-feedback mechanism in vivo.
abstractGer	Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of TRL by WAT. Following the ingestion of a 13C-triolein-labeled high-fat meal, obese women with high plasma apoB (< median 0.93 g/l, N = 11, < 98% as IDL/LDL) had delayed clearance of postprandial 13C-triglyceride and 13C-NEFA over 6 h compared with controls. AUC6 h of plasma 13C-triglyceride and 13C-NEFA correlated with plasma apoB but not with LDL diameter or adipocyte area. There was no group difference in 13C-triolein oxidation rate, which suggests lower 13C-NEFA storage in peripheral tissue in women with high apoB. Ex vivo/in vitro plasma apoB correlated negatively with WAT 3H-lipid following a 4 h incubation of women舗s WAT with synthetic 3H-triolein-TRL. LDL-differentiated 3T3-L1 adipocytes had lower 3H-TRL hydrolysis and 3H-NEFA storage. Treatment of women舗s WAT with their own LDL decreased 3H-TRL hydrolysis and 3H-NEFA uptake. Finally, LDL, although not an LPL substrate, reduced LPL-mediated 3H-TRL hydrolysis as did VLDL and HDL. Exposure to LDL decreases TRL clearance by human WAT ex vivo. This may promote production of apoB-lipoproteins and hypertriglyceridemia through a positive-feedback mechanism in vivo.
abstract_unstemmed	Delayed clearance of triglyceride-rich lipoprotein (TRL) by white adipose tissue (WAT) promotes hypertriglyceridemia and elevated apoB-lipoproteins, which are primarily in the form of LDL. This study examines whether LDL promotes delayed clearance of TRL by WAT. Following the ingestion of a 13C-triolein-labeled high-fat meal, obese women with high plasma apoB (< median 0.93 g/l, N = 11, < 98% as IDL/LDL) had delayed clearance of postprandial 13C-triglyceride and 13C-NEFA over 6 h compared with controls. AUC6 h of plasma 13C-triglyceride and 13C-NEFA correlated with plasma apoB but not with LDL diameter or adipocyte area. There was no group difference in 13C-triolein oxidation rate, which suggests lower 13C-NEFA storage in peripheral tissue in women with high apoB. Ex vivo/in vitro plasma apoB correlated negatively with WAT 3H-lipid following a 4 h incubation of women舗s WAT with synthetic 3H-triolein-TRL. LDL-differentiated 3T3-L1 adipocytes had lower 3H-TRL hydrolysis and 3H-NEFA storage. Treatment of women舗s WAT with their own LDL decreased 3H-TRL hydrolysis and 3H-NEFA uptake. Finally, LDL, although not an LPL substrate, reduced LPL-mediated 3H-TRL hydrolysis as did VLDL and HDL. Exposure to LDL decreases TRL clearance by human WAT ex vivo. This may promote production of apoB-lipoproteins and hypertriglyceridemia through a positive-feedback mechanism in vivo.
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title_short	Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue
url	https://doi.org/10.1194/jlr.P023176 https://doaj.org/article/3d6e5e7b3d1b4d069cf9c4d624aa76b7 http://www.sciencedirect.com/science/article/pii/S0022227520421832 https://doaj.org/toc/0022-2275
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Finally, LDL, although not an LPL substrate, reduced LPL-mediated 3H-TRL hydrolysis as did VLDL and HDL. Exposure to LDL decreases TRL clearance by human WAT ex vivo. 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Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue

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