Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study

The benefits of probiotic supplementation to lactating mothers on human milk cytokines are inconclusive. Thus, we performed a comprehensive open-label pilot trial analysis of 27 human milk cytokines in lactating women with allergies (one to three months postpartum) to determine the effect of supplem...
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Gespeichert in:

Autor*in:	Tomoki Takahashi [verfasserIn] Hirofumi Fukudome [verfasserIn] Hiroshi M. Ueno [verfasserIn] Shiomi Watanabe-Matsuhashi [verfasserIn] Taku Nakano [verfasserIn] Toshiya Kobayashi [verfasserIn] Kayoko Ishimaru [verfasserIn] Atsuhito Nakao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	human milk cytokine probiotics IL-10

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 13(2021), 7, p 2285
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:7, p 2285

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu13072285

Katalog-ID:	DOAJ058548823

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allfieldsGer	10.3390/nu13072285 doi (DE-627)DOAJ058548823 (DE-599)DOAJf6593ff0b925485387dc1156ed63240b DE-627 ger DE-627 rakwb eng TX341-641 Tomoki Takahashi verfasserin aut Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The benefits of probiotic supplementation to lactating mothers on human milk cytokines are inconclusive. Thus, we performed a comprehensive open-label pilot trial analysis of 27 human milk cytokines in lactating women with allergies (one to three months postpartum) to determine the effect of supplementation with a mixture of new probiotic strains. Participants voluntarily joined the probiotic (<i<n</i< = 41) or no supplementation control (<i<n</i< = 19) groups. The probiotic group took three probiotic tablets (<i<Lactobacillus casei</i< LC5, <i<Bifidobacterium longum</i< BG7, and <i<Bacillus coagulans</i< SANK70258) daily for one to three months postpartum. Milk samples were collected at one, two, and three months postpartum, and cytokine levels were measured using multiplex assays. The effects were analyzed using multivariate regression models. Eleven cytokines showed a positive rate of over 50% in the milk samples throughout testing in both groups. The positive rates of IL-1 receptor antagonist and IL-7 changed significantly with lactation progression in logistic regression models after adjusting for time and supplementation, whereas rates of other cytokines showed no significant differences. The lactational change patterns of IL-10 concentrations differed significantly between the two groups. A short-term supplementation of probiotics affects human milk cytokine levels in lactating women with a possible placebo effect still existing. Future placebo-controlled studies are needed to support these results, based on the estimated sample sizes in this study. human milk cytokine probiotics IL-10 <i<Lactobacillus casei</i< <i<Bifidobacterium longum</i< Nutrition. Foods and food supply Hirofumi Fukudome verfasserin aut Hiroshi M. Ueno verfasserin aut Shiomi Watanabe-Matsuhashi verfasserin aut Taku Nakano verfasserin aut Toshiya Kobayashi verfasserin aut Kayoko Ishimaru verfasserin aut Atsuhito Nakao verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 7, p 2285 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:7, p 2285 https://doi.org/10.3390/nu13072285 kostenfrei https://doaj.org/article/f6593ff0b925485387dc1156ed63240b kostenfrei https://www.mdpi.com/2072-6643/13/7/2285 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 7, p 2285
allfieldsSound	10.3390/nu13072285 doi (DE-627)DOAJ058548823 (DE-599)DOAJf6593ff0b925485387dc1156ed63240b DE-627 ger DE-627 rakwb eng TX341-641 Tomoki Takahashi verfasserin aut Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The benefits of probiotic supplementation to lactating mothers on human milk cytokines are inconclusive. Thus, we performed a comprehensive open-label pilot trial analysis of 27 human milk cytokines in lactating women with allergies (one to three months postpartum) to determine the effect of supplementation with a mixture of new probiotic strains. Participants voluntarily joined the probiotic (<i<n</i< = 41) or no supplementation control (<i<n</i< = 19) groups. The probiotic group took three probiotic tablets (<i<Lactobacillus casei</i< LC5, <i<Bifidobacterium longum</i< BG7, and <i<Bacillus coagulans</i< SANK70258) daily for one to three months postpartum. Milk samples were collected at one, two, and three months postpartum, and cytokine levels were measured using multiplex assays. The effects were analyzed using multivariate regression models. Eleven cytokines showed a positive rate of over 50% in the milk samples throughout testing in both groups. The positive rates of IL-1 receptor antagonist and IL-7 changed significantly with lactation progression in logistic regression models after adjusting for time and supplementation, whereas rates of other cytokines showed no significant differences. The lactational change patterns of IL-10 concentrations differed significantly between the two groups. A short-term supplementation of probiotics affects human milk cytokine levels in lactating women with a possible placebo effect still existing. Future placebo-controlled studies are needed to support these results, based on the estimated sample sizes in this study. human milk cytokine probiotics IL-10 <i<Lactobacillus casei</i< <i<Bifidobacterium longum</i< Nutrition. Foods and food supply Hirofumi Fukudome verfasserin aut Hiroshi M. Ueno verfasserin aut Shiomi Watanabe-Matsuhashi verfasserin aut Taku Nakano verfasserin aut Toshiya Kobayashi verfasserin aut Kayoko Ishimaru verfasserin aut Atsuhito Nakao verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 7, p 2285 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:7, p 2285 https://doi.org/10.3390/nu13072285 kostenfrei https://doaj.org/article/f6593ff0b925485387dc1156ed63240b kostenfrei https://www.mdpi.com/2072-6643/13/7/2285 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 7, p 2285
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callnumber-first	T - Technology
author	Tomoki Takahashi
spellingShingle	Tomoki Takahashi misc TX341-641 misc human milk misc cytokine misc probiotics misc IL-10 misc <i<Lactobacillus casei</i< misc <i<Bifidobacterium longum</i< misc Nutrition. Foods and food supply Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study
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topic_title	TX341-641 Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study human milk cytokine probiotics IL-10 <i<Lactobacillus casei</i< <i<Bifidobacterium longum</i<
topic	misc TX341-641 misc human milk misc cytokine misc probiotics misc IL-10 misc <i<Lactobacillus casei</i< misc <i<Bifidobacterium longum</i< misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc human milk misc cytokine misc probiotics misc IL-10 misc <i<Lactobacillus casei</i< misc <i<Bifidobacterium longum</i< misc Nutrition. Foods and food supply
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title	Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study
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title_full	Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study
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title_sort	probiotic supplementation and human milk cytokine profiles in japanese women: a retrospective study from an open-label pilot study
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title_auth	Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study
abstract	The benefits of probiotic supplementation to lactating mothers on human milk cytokines are inconclusive. Thus, we performed a comprehensive open-label pilot trial analysis of 27 human milk cytokines in lactating women with allergies (one to three months postpartum) to determine the effect of supplementation with a mixture of new probiotic strains. Participants voluntarily joined the probiotic (<i<n</i< = 41) or no supplementation control (<i<n</i< = 19) groups. The probiotic group took three probiotic tablets (<i<Lactobacillus casei</i< LC5, <i<Bifidobacterium longum</i< BG7, and <i<Bacillus coagulans</i< SANK70258) daily for one to three months postpartum. Milk samples were collected at one, two, and three months postpartum, and cytokine levels were measured using multiplex assays. The effects were analyzed using multivariate regression models. Eleven cytokines showed a positive rate of over 50% in the milk samples throughout testing in both groups. The positive rates of IL-1 receptor antagonist and IL-7 changed significantly with lactation progression in logistic regression models after adjusting for time and supplementation, whereas rates of other cytokines showed no significant differences. The lactational change patterns of IL-10 concentrations differed significantly between the two groups. A short-term supplementation of probiotics affects human milk cytokine levels in lactating women with a possible placebo effect still existing. Future placebo-controlled studies are needed to support these results, based on the estimated sample sizes in this study.
abstractGer	The benefits of probiotic supplementation to lactating mothers on human milk cytokines are inconclusive. Thus, we performed a comprehensive open-label pilot trial analysis of 27 human milk cytokines in lactating women with allergies (one to three months postpartum) to determine the effect of supplementation with a mixture of new probiotic strains. Participants voluntarily joined the probiotic (<i<n</i< = 41) or no supplementation control (<i<n</i< = 19) groups. The probiotic group took three probiotic tablets (<i<Lactobacillus casei</i< LC5, <i<Bifidobacterium longum</i< BG7, and <i<Bacillus coagulans</i< SANK70258) daily for one to three months postpartum. Milk samples were collected at one, two, and three months postpartum, and cytokine levels were measured using multiplex assays. The effects were analyzed using multivariate regression models. Eleven cytokines showed a positive rate of over 50% in the milk samples throughout testing in both groups. The positive rates of IL-1 receptor antagonist and IL-7 changed significantly with lactation progression in logistic regression models after adjusting for time and supplementation, whereas rates of other cytokines showed no significant differences. The lactational change patterns of IL-10 concentrations differed significantly between the two groups. A short-term supplementation of probiotics affects human milk cytokine levels in lactating women with a possible placebo effect still existing. Future placebo-controlled studies are needed to support these results, based on the estimated sample sizes in this study.
abstract_unstemmed	The benefits of probiotic supplementation to lactating mothers on human milk cytokines are inconclusive. Thus, we performed a comprehensive open-label pilot trial analysis of 27 human milk cytokines in lactating women with allergies (one to three months postpartum) to determine the effect of supplementation with a mixture of new probiotic strains. Participants voluntarily joined the probiotic (<i<n</i< = 41) or no supplementation control (<i<n</i< = 19) groups. The probiotic group took three probiotic tablets (<i<Lactobacillus casei</i< LC5, <i<Bifidobacterium longum</i< BG7, and <i<Bacillus coagulans</i< SANK70258) daily for one to three months postpartum. Milk samples were collected at one, two, and three months postpartum, and cytokine levels were measured using multiplex assays. The effects were analyzed using multivariate regression models. Eleven cytokines showed a positive rate of over 50% in the milk samples throughout testing in both groups. The positive rates of IL-1 receptor antagonist and IL-7 changed significantly with lactation progression in logistic regression models after adjusting for time and supplementation, whereas rates of other cytokines showed no significant differences. The lactational change patterns of IL-10 concentrations differed significantly between the two groups. A short-term supplementation of probiotics affects human milk cytokine levels in lactating women with a possible placebo effect still existing. Future placebo-controlled studies are needed to support these results, based on the estimated sample sizes in this study.
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title_short	Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study
url	https://doi.org/10.3390/nu13072285 https://doaj.org/article/f6593ff0b925485387dc1156ed63240b https://www.mdpi.com/2072-6643/13/7/2285 https://doaj.org/toc/2072-6643
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author2	Hirofumi Fukudome Hiroshi M. Ueno Shiomi Watanabe-Matsuhashi Taku Nakano Toshiya Kobayashi Kayoko Ishimaru Atsuhito Nakao
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up_date	2024-07-03T18:40:07.827Z
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Probiotic Supplementation and Human Milk Cytokine Profiles in Japanese Women: A Retrospective Study from an Open-Label Pilot Study

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