Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group
Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. region...
Ausführliche Beschreibung
Autor*in: |
Maria Gloria Rossetti [verfasserIn] Praveetha Patalay [verfasserIn] Scott Mackey [verfasserIn] Nicholas B. Allen [verfasserIn] Albert Batalla [verfasserIn] Marcella Bellani [verfasserIn] Yann Chye [verfasserIn] Janna Cousijn [verfasserIn] Anna E. Goudriaan [verfasserIn] Robert Hester [verfasserIn] Kent Hutchison [verfasserIn] Chiang-Shan R. Li [verfasserIn] Rocio Martin-Santos [verfasserIn] Reza Momenan [verfasserIn] Rajita Sinha [verfasserIn] Lianne Schmaal [verfasserIn] Zsuzsika Sjoerds [verfasserIn] Nadia Solowij [verfasserIn] Chao Suo [verfasserIn] Ruth J. van Holst [verfasserIn] Dick J. Veltman [verfasserIn] Murat Yücel [verfasserIn] Paul M. Thompson [verfasserIn] Patricia Conrod [verfasserIn] Hugh Garavan [verfasserIn] Paolo Brambilla [verfasserIn] Valentina Lorenzetti [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: NeuroImage: Clinical - Elsevier, 2015, 30(2021), Seite 102636- |
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Übergeordnetes Werk: |
volume:30 ; year:2021 ; pages:102636- |
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DOI / URN: |
10.1016/j.nicl.2021.102636 |
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Katalog-ID: |
DOAJ058552448 |
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520 | |a Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. | ||
650 | 4 | |a Alcohol | |
650 | 4 | |a Sex | |
650 | 4 | |a Alcohol dependence | |
650 | 4 | |a Gender differences | |
650 | 4 | |a Neuroimaging | |
650 | 4 | |a MRI | |
653 | 0 | |a Computer applications to medicine. Medical informatics | |
653 | 0 | |a Neurology. Diseases of the nervous system | |
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700 | 0 | |a Robert Hester |e verfasserin |4 aut | |
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700 | 0 | |a Paolo Brambilla |e verfasserin |4 aut | |
700 | 0 | |a Valentina Lorenzetti |e verfasserin |4 aut | |
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10.1016/j.nicl.2021.102636 doi (DE-627)DOAJ058552448 (DE-599)DOAJ2af6749bc67f4825b0f6917e0ead528d DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Maria Gloria Rossetti verfasserin aut Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. Alcohol Sex Alcohol dependence Gender differences Neuroimaging MRI Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Praveetha Patalay verfasserin aut Scott Mackey verfasserin aut Nicholas B. Allen verfasserin aut Albert Batalla verfasserin aut Marcella Bellani verfasserin aut Yann Chye verfasserin aut Janna Cousijn verfasserin aut Anna E. Goudriaan verfasserin aut Robert Hester verfasserin aut Kent Hutchison verfasserin aut Chiang-Shan R. Li verfasserin aut Rocio Martin-Santos verfasserin aut Reza Momenan verfasserin aut Rajita Sinha verfasserin aut Lianne Schmaal verfasserin aut Zsuzsika Sjoerds verfasserin aut Nadia Solowij verfasserin aut Chao Suo verfasserin aut Ruth J. van Holst verfasserin aut Dick J. Veltman verfasserin aut Murat Yücel verfasserin aut Paul M. Thompson verfasserin aut Patricia Conrod verfasserin aut Hugh Garavan verfasserin aut Paolo Brambilla verfasserin aut Valentina Lorenzetti verfasserin aut In NeuroImage: Clinical Elsevier, 2015 30(2021), Seite 102636- (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:30 year:2021 pages:102636- https://doi.org/10.1016/j.nicl.2021.102636 kostenfrei https://doaj.org/article/2af6749bc67f4825b0f6917e0ead528d kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158221000802 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2021 102636- |
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10.1016/j.nicl.2021.102636 doi (DE-627)DOAJ058552448 (DE-599)DOAJ2af6749bc67f4825b0f6917e0ead528d DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Maria Gloria Rossetti verfasserin aut Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. Alcohol Sex Alcohol dependence Gender differences Neuroimaging MRI Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Praveetha Patalay verfasserin aut Scott Mackey verfasserin aut Nicholas B. Allen verfasserin aut Albert Batalla verfasserin aut Marcella Bellani verfasserin aut Yann Chye verfasserin aut Janna Cousijn verfasserin aut Anna E. Goudriaan verfasserin aut Robert Hester verfasserin aut Kent Hutchison verfasserin aut Chiang-Shan R. Li verfasserin aut Rocio Martin-Santos verfasserin aut Reza Momenan verfasserin aut Rajita Sinha verfasserin aut Lianne Schmaal verfasserin aut Zsuzsika Sjoerds verfasserin aut Nadia Solowij verfasserin aut Chao Suo verfasserin aut Ruth J. van Holst verfasserin aut Dick J. Veltman verfasserin aut Murat Yücel verfasserin aut Paul M. Thompson verfasserin aut Patricia Conrod verfasserin aut Hugh Garavan verfasserin aut Paolo Brambilla verfasserin aut Valentina Lorenzetti verfasserin aut In NeuroImage: Clinical Elsevier, 2015 30(2021), Seite 102636- (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:30 year:2021 pages:102636- https://doi.org/10.1016/j.nicl.2021.102636 kostenfrei https://doaj.org/article/2af6749bc67f4825b0f6917e0ead528d kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158221000802 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2021 102636- |
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10.1016/j.nicl.2021.102636 doi (DE-627)DOAJ058552448 (DE-599)DOAJ2af6749bc67f4825b0f6917e0ead528d DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Maria Gloria Rossetti verfasserin aut Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. Alcohol Sex Alcohol dependence Gender differences Neuroimaging MRI Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Praveetha Patalay verfasserin aut Scott Mackey verfasserin aut Nicholas B. Allen verfasserin aut Albert Batalla verfasserin aut Marcella Bellani verfasserin aut Yann Chye verfasserin aut Janna Cousijn verfasserin aut Anna E. Goudriaan verfasserin aut Robert Hester verfasserin aut Kent Hutchison verfasserin aut Chiang-Shan R. Li verfasserin aut Rocio Martin-Santos verfasserin aut Reza Momenan verfasserin aut Rajita Sinha verfasserin aut Lianne Schmaal verfasserin aut Zsuzsika Sjoerds verfasserin aut Nadia Solowij verfasserin aut Chao Suo verfasserin aut Ruth J. van Holst verfasserin aut Dick J. Veltman verfasserin aut Murat Yücel verfasserin aut Paul M. Thompson verfasserin aut Patricia Conrod verfasserin aut Hugh Garavan verfasserin aut Paolo Brambilla verfasserin aut Valentina Lorenzetti verfasserin aut In NeuroImage: Clinical Elsevier, 2015 30(2021), Seite 102636- (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:30 year:2021 pages:102636- https://doi.org/10.1016/j.nicl.2021.102636 kostenfrei https://doaj.org/article/2af6749bc67f4825b0f6917e0ead528d kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158221000802 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2021 102636- |
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10.1016/j.nicl.2021.102636 doi (DE-627)DOAJ058552448 (DE-599)DOAJ2af6749bc67f4825b0f6917e0ead528d DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Maria Gloria Rossetti verfasserin aut Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. Alcohol Sex Alcohol dependence Gender differences Neuroimaging MRI Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Praveetha Patalay verfasserin aut Scott Mackey verfasserin aut Nicholas B. Allen verfasserin aut Albert Batalla verfasserin aut Marcella Bellani verfasserin aut Yann Chye verfasserin aut Janna Cousijn verfasserin aut Anna E. Goudriaan verfasserin aut Robert Hester verfasserin aut Kent Hutchison verfasserin aut Chiang-Shan R. Li verfasserin aut Rocio Martin-Santos verfasserin aut Reza Momenan verfasserin aut Rajita Sinha verfasserin aut Lianne Schmaal verfasserin aut Zsuzsika Sjoerds verfasserin aut Nadia Solowij verfasserin aut Chao Suo verfasserin aut Ruth J. van Holst verfasserin aut Dick J. Veltman verfasserin aut Murat Yücel verfasserin aut Paul M. Thompson verfasserin aut Patricia Conrod verfasserin aut Hugh Garavan verfasserin aut Paolo Brambilla verfasserin aut Valentina Lorenzetti verfasserin aut In NeuroImage: Clinical Elsevier, 2015 30(2021), Seite 102636- (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:30 year:2021 pages:102636- https://doi.org/10.1016/j.nicl.2021.102636 kostenfrei https://doaj.org/article/2af6749bc67f4825b0f6917e0ead528d kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158221000802 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 30 2021 102636- |
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Maria Gloria Rossetti @@aut@@ Praveetha Patalay @@aut@@ Scott Mackey @@aut@@ Nicholas B. Allen @@aut@@ Albert Batalla @@aut@@ Marcella Bellani @@aut@@ Yann Chye @@aut@@ Janna Cousijn @@aut@@ Anna E. Goudriaan @@aut@@ Robert Hester @@aut@@ Kent Hutchison @@aut@@ Chiang-Shan R. Li @@aut@@ Rocio Martin-Santos @@aut@@ Reza Momenan @@aut@@ Rajita Sinha @@aut@@ Lianne Schmaal @@aut@@ Zsuzsika Sjoerds @@aut@@ Nadia Solowij @@aut@@ Chao Suo @@aut@@ Ruth J. van Holst @@aut@@ Dick J. Veltman @@aut@@ Murat Yücel @@aut@@ Paul M. Thompson @@aut@@ Patricia Conrod @@aut@@ Hugh Garavan @@aut@@ Paolo Brambilla @@aut@@ Valentina Lorenzetti @@aut@@ |
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However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. 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R858-859.7 RC346-429 Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group Alcohol Sex Alcohol dependence Gender differences Neuroimaging MRI |
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Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group |
abstract |
Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. |
abstractGer |
Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. |
abstract_unstemmed |
Gender-related differences in the susceptibility, progression and clinical outcomes of alcohol dependence are well-known. However, the neurobiological substrates underlying such differences remain unclear. Therefore, this study aimed to investigate gender differences in the neuroanatomy (i.e. regional brain volumes) of alcohol dependence. We examined the volume of a priori regions of interest (i.e., orbitofrontal cortex, hippocampus, amygdala, nucleus accumbens, caudate, putamen, pallidum, thalamus, corpus callosum, cerebellum) and global brain measures (i.e., total grey matter (GM), total white matter (WM) and cerebrospinal fluid). Volumes were compared between 660 people with alcohol dependence (228 women) and 326 controls (99 women) recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age and education years. Compared to controls, individuals with alcohol dependence on average had (3–9%) smaller volumes of the hippocampus (bilateral), putamen (left), pallidum (left), thalamus (right), corpus callosum, total GM and WM, and cerebellar GM (bilateral), the latter more prominently in women (right). Alcohol-dependent men showed smaller amygdala volume than control men, but this effect was unclear among women. In people with alcohol dependence, more monthly standard drinks predicted smaller amygdala and larger cerebellum GM volumes. The neuroanatomical differences associated with alcohol dependence emerged as gross and widespread, while those associated with a specific gender may be confined to selected brain regions. These findings warrant future neuroscience research to account for gender differences in alcohol dependence to further understand the neurobiological effects of alcohol dependence. |
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title_short |
Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group |
url |
https://doi.org/10.1016/j.nicl.2021.102636 https://doaj.org/article/2af6749bc67f4825b0f6917e0ead528d http://www.sciencedirect.com/science/article/pii/S2213158221000802 https://doaj.org/toc/2213-1582 |
remote_bool |
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author2 |
Praveetha Patalay Scott Mackey Nicholas B. Allen Albert Batalla Marcella Bellani Yann Chye Janna Cousijn Anna E. Goudriaan Robert Hester Kent Hutchison Chiang-Shan R. Li Rocio Martin-Santos Reza Momenan Rajita Sinha Lianne Schmaal Zsuzsika Sjoerds Nadia Solowij Chao Suo Ruth J. van Holst Dick J. Veltman Murat Yücel Paul M. Thompson Patricia Conrod Hugh Garavan Paolo Brambilla Valentina Lorenzetti |
author2Str |
Praveetha Patalay Scott Mackey Nicholas B. Allen Albert Batalla Marcella Bellani Yann Chye Janna Cousijn Anna E. Goudriaan Robert Hester Kent Hutchison Chiang-Shan R. Li Rocio Martin-Santos Reza Momenan Rajita Sinha Lianne Schmaal Zsuzsika Sjoerds Nadia Solowij Chao Suo Ruth J. van Holst Dick J. Veltman Murat Yücel Paul M. Thompson Patricia Conrod Hugh Garavan Paolo Brambilla Valentina Lorenzetti |
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doi_str |
10.1016/j.nicl.2021.102636 |
callnumber-a |
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up_date |
2024-07-03T18:41:31.282Z |
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|
score |
7.4002314 |