Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies

Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-der...
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Gespeichert in:

Autor*in:	Shawna Benjamin-Davalos [verfasserIn] Marina Koroleva [verfasserIn] Cheryl L. Allen [verfasserIn] Marc S. Ernstoff [verfasserIn] Shin La Shu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	cytokine co-isolation exosome-associated cytokines exosome isolation tumor microenvironment melanoma soluble cytokines

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2021.638111

Katalog-ID:	DOAJ058703829

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520			\|a Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment. The co-elution of exosomes and soluble factors such as cytokines during isolation, however, make it difficult to ascertain the contribution of exosome cargo, as soluble cytokines are equally capable of immune suppression. In this review we will expound upon the biological relevance that exosome-associated cytokines possess. Furthermore, we discuss the technical challenges that arise during exosome isolation and what this means for further studies into the TME and in vivo work.
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spelling	10.3389/fimmu.2021.638111 doi (DE-627)DOAJ058703829 (DE-599)DOAJ71389f01899f4703a88e8e287703b6c9 DE-627 ger DE-627 rakwb eng RC581-607 Shawna Benjamin-Davalos verfasserin aut Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment. The co-elution of exosomes and soluble factors such as cytokines during isolation, however, make it difficult to ascertain the contribution of exosome cargo, as soluble cytokines are equally capable of immune suppression. In this review we will expound upon the biological relevance that exosome-associated cytokines possess. Furthermore, we discuss the technical challenges that arise during exosome isolation and what this means for further studies into the TME and in vivo work. cytokine co-isolation exosome-associated cytokines exosome isolation tumor microenvironment melanoma soluble cytokines Immunologic diseases. Allergy Marina Koroleva verfasserin aut Cheryl L. Allen verfasserin aut Marc S. Ernstoff verfasserin aut Marc S. Ernstoff verfasserin aut Shin La Shu verfasserin aut Shin La Shu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.638111 kostenfrei https://doaj.org/article/71389f01899f4703a88e8e287703b6c9 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.638111/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
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allfieldsGer	10.3389/fimmu.2021.638111 doi (DE-627)DOAJ058703829 (DE-599)DOAJ71389f01899f4703a88e8e287703b6c9 DE-627 ger DE-627 rakwb eng RC581-607 Shawna Benjamin-Davalos verfasserin aut Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment. The co-elution of exosomes and soluble factors such as cytokines during isolation, however, make it difficult to ascertain the contribution of exosome cargo, as soluble cytokines are equally capable of immune suppression. In this review we will expound upon the biological relevance that exosome-associated cytokines possess. Furthermore, we discuss the technical challenges that arise during exosome isolation and what this means for further studies into the TME and in vivo work. cytokine co-isolation exosome-associated cytokines exosome isolation tumor microenvironment melanoma soluble cytokines Immunologic diseases. Allergy Marina Koroleva verfasserin aut Cheryl L. Allen verfasserin aut Marc S. Ernstoff verfasserin aut Marc S. Ernstoff verfasserin aut Shin La Shu verfasserin aut Shin La Shu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.638111 kostenfrei https://doaj.org/article/71389f01899f4703a88e8e287703b6c9 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.638111/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fimmu.2021.638111 doi (DE-627)DOAJ058703829 (DE-599)DOAJ71389f01899f4703a88e8e287703b6c9 DE-627 ger DE-627 rakwb eng RC581-607 Shawna Benjamin-Davalos verfasserin aut Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment. The co-elution of exosomes and soluble factors such as cytokines during isolation, however, make it difficult to ascertain the contribution of exosome cargo, as soluble cytokines are equally capable of immune suppression. In this review we will expound upon the biological relevance that exosome-associated cytokines possess. Furthermore, we discuss the technical challenges that arise during exosome isolation and what this means for further studies into the TME and in vivo work. cytokine co-isolation exosome-associated cytokines exosome isolation tumor microenvironment melanoma soluble cytokines Immunologic diseases. Allergy Marina Koroleva verfasserin aut Cheryl L. Allen verfasserin aut Marc S. Ernstoff verfasserin aut Marc S. Ernstoff verfasserin aut Shin La Shu verfasserin aut Shin La Shu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.638111 kostenfrei https://doaj.org/article/71389f01899f4703a88e8e287703b6c9 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.638111/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Immunology 12(2021) volume:12 year:2021
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topic_facet	cytokine co-isolation exosome-associated cytokines exosome isolation tumor microenvironment melanoma soluble cytokines Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Shawna Benjamin-Davalos @@aut@@ Marina Koroleva @@aut@@ Cheryl L. Allen @@aut@@ Marc S. Ernstoff @@aut@@ Shin La Shu @@aut@@
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callnumber-first	R - Medicine
author	Shawna Benjamin-Davalos
spellingShingle	Shawna Benjamin-Davalos misc RC581-607 misc cytokine co-isolation misc exosome-associated cytokines misc exosome isolation misc tumor microenvironment misc melanoma misc soluble cytokines misc Immunologic diseases. Allergy Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies
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topic_title	RC581-607 Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies cytokine co-isolation exosome-associated cytokines exosome isolation tumor microenvironment melanoma soluble cytokines
topic	misc RC581-607 misc cytokine co-isolation misc exosome-associated cytokines misc exosome isolation misc tumor microenvironment misc melanoma misc soluble cytokines misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc cytokine co-isolation misc exosome-associated cytokines misc exosome isolation misc tumor microenvironment misc melanoma misc soluble cytokines misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc cytokine co-isolation misc exosome-associated cytokines misc exosome isolation misc tumor microenvironment misc melanoma misc soluble cytokines misc Immunologic diseases. Allergy
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title	Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies
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title_full	Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies
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title_sort	co-isolation of cytokines and exosomes: implications for immunomodulation studies
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title_auth	Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies
abstract	Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment. The co-elution of exosomes and soluble factors such as cytokines during isolation, however, make it difficult to ascertain the contribution of exosome cargo, as soluble cytokines are equally capable of immune suppression. In this review we will expound upon the biological relevance that exosome-associated cytokines possess. Furthermore, we discuss the technical challenges that arise during exosome isolation and what this means for further studies into the TME and in vivo work.
abstractGer	Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment. The co-elution of exosomes and soluble factors such as cytokines during isolation, however, make it difficult to ascertain the contribution of exosome cargo, as soluble cytokines are equally capable of immune suppression. In this review we will expound upon the biological relevance that exosome-associated cytokines possess. Furthermore, we discuss the technical challenges that arise during exosome isolation and what this means for further studies into the TME and in vivo work.
abstract_unstemmed	Exosomes play a vital role in intercellular communication and their immunomodulatory potential have become an important focus in cancer research. Various methods have been developed for the isolation although each method differs in the number and purity of exosomes they yield. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment. The co-elution of exosomes and soluble factors such as cytokines during isolation, however, make it difficult to ascertain the contribution of exosome cargo, as soluble cytokines are equally capable of immune suppression. In this review we will expound upon the biological relevance that exosome-associated cytokines possess. Furthermore, we discuss the technical challenges that arise during exosome isolation and what this means for further studies into the TME and in vivo work.
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title_short	Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies
url	https://doi.org/10.3389/fimmu.2021.638111 https://doaj.org/article/71389f01899f4703a88e8e287703b6c9 https://www.frontiersin.org/articles/10.3389/fimmu.2021.638111/full https://doaj.org/toc/1664-3224
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