Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project
A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and hos...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sakae Saito [verfasserIn] Yuichi Aoki [verfasserIn] Toru Tamahara [verfasserIn] Maki Goto [verfasserIn] Hiroyuki Matsui [verfasserIn] Junko Kawashima [verfasserIn] Inaho Danjoh [verfasserIn] Atsushi Hozawa [verfasserIn] Shinichi Kuriyama [verfasserIn] Yoichi Suzuki [verfasserIn] Nobuo Fuse [verfasserIn] Shigeo Kure [verfasserIn] Riu Yamashita [verfasserIn] Osamu Tanabe [verfasserIn] Naoko Minegishi [verfasserIn] Kengo Kinoshita [verfasserIn] Akito Tsuboi [verfasserIn] Ritsuko Shimizu [verfasserIn] Masayuki Yamamoto [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Frontiers in Cellular and Infection Microbiology - Frontiers Media S.A., 2016, 10(2021) |
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| Übergeordnetes Werk: |
volume:10 ; year:2021 |
| Links: |
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| DOI / URN: |
10.3389/fcimb.2020.604596 |
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| Katalog-ID: |
DOAJ058741429 |
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| 520 | |a A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. | ||
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10.3389/fcimb.2020.604596 doi (DE-627)DOAJ058741429 (DE-599)DOAJ9a24a0a4c6154f059523791ac9c6e3b9 DE-627 ger DE-627 rakwb eng QR1-502 Sakae Saito verfasserin aut Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. 16S ribosomal RNA saliva dental plaque microbiome periodontal disease prospective cohort Microbiology Yuichi Aoki verfasserin aut Yuichi Aoki verfasserin aut Toru Tamahara verfasserin aut Toru Tamahara verfasserin aut Maki Goto verfasserin aut Hiroyuki Matsui verfasserin aut Hiroyuki Matsui verfasserin aut Junko Kawashima verfasserin aut Inaho Danjoh verfasserin aut Inaho Danjoh verfasserin aut Atsushi Hozawa verfasserin aut Atsushi Hozawa verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Yoichi Suzuki verfasserin aut Yoichi Suzuki verfasserin aut Nobuo Fuse verfasserin aut Nobuo Fuse verfasserin aut Shigeo Kure verfasserin aut Shigeo Kure verfasserin aut Riu Yamashita verfasserin aut Riu Yamashita verfasserin aut Osamu Tanabe verfasserin aut Osamu Tanabe verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Ritsuko Shimizu verfasserin aut Ritsuko Shimizu verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.604596 kostenfrei https://doaj.org/article/9a24a0a4c6154f059523791ac9c6e3b9 kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.604596/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 |
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10.3389/fcimb.2020.604596 doi (DE-627)DOAJ058741429 (DE-599)DOAJ9a24a0a4c6154f059523791ac9c6e3b9 DE-627 ger DE-627 rakwb eng QR1-502 Sakae Saito verfasserin aut Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. 16S ribosomal RNA saliva dental plaque microbiome periodontal disease prospective cohort Microbiology Yuichi Aoki verfasserin aut Yuichi Aoki verfasserin aut Toru Tamahara verfasserin aut Toru Tamahara verfasserin aut Maki Goto verfasserin aut Hiroyuki Matsui verfasserin aut Hiroyuki Matsui verfasserin aut Junko Kawashima verfasserin aut Inaho Danjoh verfasserin aut Inaho Danjoh verfasserin aut Atsushi Hozawa verfasserin aut Atsushi Hozawa verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Yoichi Suzuki verfasserin aut Yoichi Suzuki verfasserin aut Nobuo Fuse verfasserin aut Nobuo Fuse verfasserin aut Shigeo Kure verfasserin aut Shigeo Kure verfasserin aut Riu Yamashita verfasserin aut Riu Yamashita verfasserin aut Osamu Tanabe verfasserin aut Osamu Tanabe verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Ritsuko Shimizu verfasserin aut Ritsuko Shimizu verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.604596 kostenfrei https://doaj.org/article/9a24a0a4c6154f059523791ac9c6e3b9 kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.604596/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 |
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10.3389/fcimb.2020.604596 doi (DE-627)DOAJ058741429 (DE-599)DOAJ9a24a0a4c6154f059523791ac9c6e3b9 DE-627 ger DE-627 rakwb eng QR1-502 Sakae Saito verfasserin aut Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. 16S ribosomal RNA saliva dental plaque microbiome periodontal disease prospective cohort Microbiology Yuichi Aoki verfasserin aut Yuichi Aoki verfasserin aut Toru Tamahara verfasserin aut Toru Tamahara verfasserin aut Maki Goto verfasserin aut Hiroyuki Matsui verfasserin aut Hiroyuki Matsui verfasserin aut Junko Kawashima verfasserin aut Inaho Danjoh verfasserin aut Inaho Danjoh verfasserin aut Atsushi Hozawa verfasserin aut Atsushi Hozawa verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Yoichi Suzuki verfasserin aut Yoichi Suzuki verfasserin aut Nobuo Fuse verfasserin aut Nobuo Fuse verfasserin aut Shigeo Kure verfasserin aut Shigeo Kure verfasserin aut Riu Yamashita verfasserin aut Riu Yamashita verfasserin aut Osamu Tanabe verfasserin aut Osamu Tanabe verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Ritsuko Shimizu verfasserin aut Ritsuko Shimizu verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.604596 kostenfrei https://doaj.org/article/9a24a0a4c6154f059523791ac9c6e3b9 kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.604596/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 |
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10.3389/fcimb.2020.604596 doi (DE-627)DOAJ058741429 (DE-599)DOAJ9a24a0a4c6154f059523791ac9c6e3b9 DE-627 ger DE-627 rakwb eng QR1-502 Sakae Saito verfasserin aut Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. 16S ribosomal RNA saliva dental plaque microbiome periodontal disease prospective cohort Microbiology Yuichi Aoki verfasserin aut Yuichi Aoki verfasserin aut Toru Tamahara verfasserin aut Toru Tamahara verfasserin aut Maki Goto verfasserin aut Hiroyuki Matsui verfasserin aut Hiroyuki Matsui verfasserin aut Junko Kawashima verfasserin aut Inaho Danjoh verfasserin aut Inaho Danjoh verfasserin aut Atsushi Hozawa verfasserin aut Atsushi Hozawa verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Yoichi Suzuki verfasserin aut Yoichi Suzuki verfasserin aut Nobuo Fuse verfasserin aut Nobuo Fuse verfasserin aut Shigeo Kure verfasserin aut Shigeo Kure verfasserin aut Riu Yamashita verfasserin aut Riu Yamashita verfasserin aut Osamu Tanabe verfasserin aut Osamu Tanabe verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Ritsuko Shimizu verfasserin aut Ritsuko Shimizu verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.604596 kostenfrei https://doaj.org/article/9a24a0a4c6154f059523791ac9c6e3b9 kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.604596/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 |
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10.3389/fcimb.2020.604596 doi (DE-627)DOAJ058741429 (DE-599)DOAJ9a24a0a4c6154f059523791ac9c6e3b9 DE-627 ger DE-627 rakwb eng QR1-502 Sakae Saito verfasserin aut Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. 16S ribosomal RNA saliva dental plaque microbiome periodontal disease prospective cohort Microbiology Yuichi Aoki verfasserin aut Yuichi Aoki verfasserin aut Toru Tamahara verfasserin aut Toru Tamahara verfasserin aut Maki Goto verfasserin aut Hiroyuki Matsui verfasserin aut Hiroyuki Matsui verfasserin aut Junko Kawashima verfasserin aut Inaho Danjoh verfasserin aut Inaho Danjoh verfasserin aut Atsushi Hozawa verfasserin aut Atsushi Hozawa verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Shinichi Kuriyama verfasserin aut Yoichi Suzuki verfasserin aut Yoichi Suzuki verfasserin aut Nobuo Fuse verfasserin aut Nobuo Fuse verfasserin aut Shigeo Kure verfasserin aut Shigeo Kure verfasserin aut Riu Yamashita verfasserin aut Riu Yamashita verfasserin aut Osamu Tanabe verfasserin aut Osamu Tanabe verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Naoko Minegishi verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Kengo Kinoshita verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Akito Tsuboi verfasserin aut Ritsuko Shimizu verfasserin aut Ritsuko Shimizu verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut Masayuki Yamamoto verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.604596 kostenfrei https://doaj.org/article/9a24a0a4c6154f059523791ac9c6e3b9 kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.604596/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 |
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Sakae Saito @@aut@@ Yuichi Aoki @@aut@@ Toru Tamahara @@aut@@ Maki Goto @@aut@@ Hiroyuki Matsui @@aut@@ Junko Kawashima @@aut@@ Inaho Danjoh @@aut@@ Atsushi Hozawa @@aut@@ Shinichi Kuriyama @@aut@@ Yoichi Suzuki @@aut@@ Nobuo Fuse @@aut@@ Shigeo Kure @@aut@@ Riu Yamashita @@aut@@ Osamu Tanabe @@aut@@ Naoko Minegishi @@aut@@ Kengo Kinoshita @@aut@@ Akito Tsuboi @@aut@@ Ritsuko Shimizu @@aut@@ Masayuki Yamamoto @@aut@@ |
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Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project |
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A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. |
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A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. |
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A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases. |
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