Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels

<p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) t...
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Gespeichert in:

Autor*in:	Winkelman-Sim Dianne C [verfasserIn] Thue Tracey D [verfasserIn] Van Kessel Andrew G [verfasserIn] Fitzsimmons Carolyn J [verfasserIn] Buchanan Fiona C [verfasserIn] Schmutz Sheila M [verfasserIn]

Format:	E-Artikel
Sprache:	Deutsch ; Englisch ; Französisch

Erschienen:	2002

Schlagwörter:	leptin cattle obese fat marbling

Übergeordnetes Werk:	In: Genetics Selection Evolution - BMC, 2009, 34(2002), 1, Seite 105-116
Übergeordnetes Werk:	volume:34 ; year:2002 ; number:1 ; pages:105-116

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1186/1297-9686-34-1-105

Katalog-ID:	DOAJ05874634X

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allfields	10.1186/1297-9686-34-1-105 doi (DE-627)DOAJ05874634X (DE-599)DOAJf2a9652c6625448db196bfbe28c18bd9 DE-627 ger DE-627 rakwb ger eng fre SF1-1100 QH426-470 Winkelman-Sim Dianne C verfasserin aut Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.</p< leptin cattle obese fat marbling Animal culture Genetics Thue Tracey D verfasserin aut Van Kessel Andrew G verfasserin aut Fitzsimmons Carolyn J verfasserin aut Buchanan Fiona C verfasserin aut Schmutz Sheila M verfasserin aut In Genetics Selection Evolution BMC, 2009 34(2002), 1, Seite 105-116 (DE-627)312849052 (DE-600)2012369-3 12979686 nnns volume:34 year:2002 number:1 pages:105-116 https://doi.org/10.1186/1297-9686-34-1-105 kostenfrei https://doaj.org/article/f2a9652c6625448db196bfbe28c18bd9 kostenfrei http://www.gsejournal.org/content/34/1/105 kostenfrei https://doaj.org/toc/0999-193X Journal toc kostenfrei https://doaj.org/toc/1297-9686 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 34 2002 1 105-116
spelling	10.1186/1297-9686-34-1-105 doi (DE-627)DOAJ05874634X (DE-599)DOAJf2a9652c6625448db196bfbe28c18bd9 DE-627 ger DE-627 rakwb ger eng fre SF1-1100 QH426-470 Winkelman-Sim Dianne C verfasserin aut Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.</p< leptin cattle obese fat marbling Animal culture Genetics Thue Tracey D verfasserin aut Van Kessel Andrew G verfasserin aut Fitzsimmons Carolyn J verfasserin aut Buchanan Fiona C verfasserin aut Schmutz Sheila M verfasserin aut In Genetics Selection Evolution BMC, 2009 34(2002), 1, Seite 105-116 (DE-627)312849052 (DE-600)2012369-3 12979686 nnns volume:34 year:2002 number:1 pages:105-116 https://doi.org/10.1186/1297-9686-34-1-105 kostenfrei https://doaj.org/article/f2a9652c6625448db196bfbe28c18bd9 kostenfrei http://www.gsejournal.org/content/34/1/105 kostenfrei https://doaj.org/toc/0999-193X Journal toc kostenfrei https://doaj.org/toc/1297-9686 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 34 2002 1 105-116
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allfieldsGer	10.1186/1297-9686-34-1-105 doi (DE-627)DOAJ05874634X (DE-599)DOAJf2a9652c6625448db196bfbe28c18bd9 DE-627 ger DE-627 rakwb ger eng fre SF1-1100 QH426-470 Winkelman-Sim Dianne C verfasserin aut Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.</p< leptin cattle obese fat marbling Animal culture Genetics Thue Tracey D verfasserin aut Van Kessel Andrew G verfasserin aut Fitzsimmons Carolyn J verfasserin aut Buchanan Fiona C verfasserin aut Schmutz Sheila M verfasserin aut In Genetics Selection Evolution BMC, 2009 34(2002), 1, Seite 105-116 (DE-627)312849052 (DE-600)2012369-3 12979686 nnns volume:34 year:2002 number:1 pages:105-116 https://doi.org/10.1186/1297-9686-34-1-105 kostenfrei https://doaj.org/article/f2a9652c6625448db196bfbe28c18bd9 kostenfrei http://www.gsejournal.org/content/34/1/105 kostenfrei https://doaj.org/toc/0999-193X Journal toc kostenfrei https://doaj.org/toc/1297-9686 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 34 2002 1 105-116
allfieldsSound	10.1186/1297-9686-34-1-105 doi (DE-627)DOAJ05874634X (DE-599)DOAJf2a9652c6625448db196bfbe28c18bd9 DE-627 ger DE-627 rakwb ger eng fre SF1-1100 QH426-470 Winkelman-Sim Dianne C verfasserin aut Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.</p< leptin cattle obese fat marbling Animal culture Genetics Thue Tracey D verfasserin aut Van Kessel Andrew G verfasserin aut Fitzsimmons Carolyn J verfasserin aut Buchanan Fiona C verfasserin aut Schmutz Sheila M verfasserin aut In Genetics Selection Evolution BMC, 2009 34(2002), 1, Seite 105-116 (DE-627)312849052 (DE-600)2012369-3 12979686 nnns volume:34 year:2002 number:1 pages:105-116 https://doi.org/10.1186/1297-9686-34-1-105 kostenfrei https://doaj.org/article/f2a9652c6625448db196bfbe28c18bd9 kostenfrei http://www.gsejournal.org/content/34/1/105 kostenfrei https://doaj.org/toc/0999-193X Journal toc kostenfrei https://doaj.org/toc/1297-9686 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 34 2002 1 105-116
language	German English French
source	In Genetics Selection Evolution 34(2002), 1, Seite 105-116 volume:34 year:2002 number:1 pages:105-116
sourceStr	In Genetics Selection Evolution 34(2002), 1, Seite 105-116 volume:34 year:2002 number:1 pages:105-116
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topic_facet	leptin cattle obese fat marbling Animal culture Genetics
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authorswithroles_txt_mv	Winkelman-Sim Dianne C @@aut@@ Thue Tracey D @@aut@@ Van Kessel Andrew G @@aut@@ Fitzsimmons Carolyn J @@aut@@ Buchanan Fiona C @@aut@@ Schmutz Sheila M @@aut@@
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callnumber-first	S - Agriculture
author	Winkelman-Sim Dianne C
spellingShingle	Winkelman-Sim Dianne C misc SF1-1100 misc QH426-470 misc leptin misc cattle misc obese misc fat misc marbling misc Animal culture misc Genetics Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
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topic_title	SF1-1100 QH426-470 Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels leptin cattle obese fat marbling
topic	misc SF1-1100 misc QH426-470 misc leptin misc cattle misc obese misc fat misc marbling misc Animal culture misc Genetics
topic_unstemmed	misc SF1-1100 misc QH426-470 misc leptin misc cattle misc obese misc fat misc marbling misc Animal culture misc Genetics
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title	Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
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title_full	Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
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title_sort	association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mrna levels
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title_auth	Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
abstract	<p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.</p<
abstractGer	<p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.</p<
abstract_unstemmed	<p<Abstract</p< <p<Previously, we have shown that alleles of the <it<BM1500 </it<microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.</p<
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title_short	Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
url	https://doi.org/10.1186/1297-9686-34-1-105 https://doaj.org/article/f2a9652c6625448db196bfbe28c18bd9 http://www.gsejournal.org/content/34/1/105 https://doaj.org/toc/0999-193X https://doaj.org/toc/1297-9686
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Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels

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