Chemistry and Toxicology of Major Bioactive Substances in <i<Inocybe</i< Mushrooms

Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in pois...
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Autor*in:	Jiri Patocka [verfasserIn] Ran Wu [verfasserIn] Eugenie Nepovimova [verfasserIn] Martin Valis [verfasserIn] Wenda Wu [verfasserIn] Kamil Kuca [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	muscarine psilocybin psilocin toxicology

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 22(2021), 4, p 2218
Übergeordnetes Werk:	volume:22 ; year:2021 ; number:4, p 2218

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms22042218

Katalog-ID:	DOAJ058789588

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author	Jiri Patocka
spellingShingle	Jiri Patocka misc QH301-705.5 misc QD1-999 misc <i<Inocybe</i< mushroom misc muscarine misc psilocybin misc psilocin misc toxicology misc Biology (General) misc Chemistry Chemistry and Toxicology of Major Bioactive Substances in <i<Inocybe</i< Mushrooms
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title_auth	Chemistry and Toxicology of Major Bioactive Substances in <i<Inocybe</i< Mushrooms
abstract	Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. <i<Inocybe</i< is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. In this review article, we summarize the chemistry, most known toxic effects and mechanisms of major toxic substances in <i<Inocybe</i< mushrooms, especially muscarine, psilocybin and psilocin. Their available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the treatment and medical application of these toxic substances in <i<Inocybe</i< mushrooms are also discussed. We hope that this review will help understanding of the chemistry and toxicology of <i<Inocybe</i< mushrooms as well as the potential clinical application of its bioactive substances to benefit human beings.
abstractGer	Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. <i<Inocybe</i< is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. In this review article, we summarize the chemistry, most known toxic effects and mechanisms of major toxic substances in <i<Inocybe</i< mushrooms, especially muscarine, psilocybin and psilocin. Their available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the treatment and medical application of these toxic substances in <i<Inocybe</i< mushrooms are also discussed. We hope that this review will help understanding of the chemistry and toxicology of <i<Inocybe</i< mushrooms as well as the potential clinical application of its bioactive substances to benefit human beings.
abstract_unstemmed	Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. <i<Inocybe</i< is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. In this review article, we summarize the chemistry, most known toxic effects and mechanisms of major toxic substances in <i<Inocybe</i< mushrooms, especially muscarine, psilocybin and psilocin. Their available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the treatment and medical application of these toxic substances in <i<Inocybe</i< mushrooms are also discussed. We hope that this review will help understanding of the chemistry and toxicology of <i<Inocybe</i< mushrooms as well as the potential clinical application of its bioactive substances to benefit human beings.
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There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. <i<Inocybe</i< is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. In this review article, we summarize the chemistry, most known toxic effects and mechanisms of major toxic substances in <i<Inocybe</i< mushrooms, especially muscarine, psilocybin and psilocin. Their available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the treatment and medical application of these toxic substances in <i<Inocybe</i< mushrooms are also discussed. 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Chemistry and Toxicology of Major Bioactive Substances in <i<Inocybe</i< Mushrooms

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