The Role of Sphingolipids in Allergic Disorders

Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different...
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Gespeichert in:

Autor*in:	Araceli Díaz-Perales [verfasserIn] Maria M. Escribese [verfasserIn] María Garrido-Arandia [verfasserIn] David Obeso [verfasserIn] Elena Izquierdo-Alvarez [verfasserIn] Jaime Tome-Amat [verfasserIn] Domingo Barber [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	sphingolipid inflammation allergy sphigosine-1-P ceramide-1-P disruption epithelial barrier

Übergeordnetes Werk:	In: Frontiers in Allergy - Frontiers Media S.A., 2021, 2(2021)
Übergeordnetes Werk:	volume:2 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/falgy.2021.675557

Katalog-ID:	DOAJ058857915

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spelling	10.3389/falgy.2021.675557 doi (DE-627)DOAJ058857915 (DE-599)DOAJ0a4481d63f334c13947c0b72967e7af7 DE-627 ger DE-627 rakwb eng RC581-607 Araceli Díaz-Perales verfasserin aut The Role of Sphingolipids in Allergic Disorders 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different human pathologies such as neurological disorders, cancer, autoimmunity, and infections. Sphingolipid metabolites, in particular, ceramide and sphingosine-1-phosphate (S1P), regulate a diverse range of cellular processes that are important in immunity and inflammation. Moreover, variations in the sphingolipid concentrations have been strongly associated with allergic diseases. This review will focus on the role of sphingolipids in the development of allergic sensitization and allergic inflammation through the activation of immune cells resident in tissues, as well as their role in barrier remodeling and anaphylaxis. The knowledge gained in this emerging field will help to develop new therapeutic options for allergic disorders. sphingolipid inflammation allergy sphigosine-1-P ceramide-1-P disruption epithelial barrier Immunologic diseases. Allergy Maria M. Escribese verfasserin aut María Garrido-Arandia verfasserin aut David Obeso verfasserin aut Elena Izquierdo-Alvarez verfasserin aut Jaime Tome-Amat verfasserin aut Domingo Barber verfasserin aut In Frontiers in Allergy Frontiers Media S.A., 2021 2(2021) (DE-627)1757639608 (DE-600)3063831-8 26736101 nnns volume:2 year:2021 https://doi.org/10.3389/falgy.2021.675557 kostenfrei https://doaj.org/article/0a4481d63f334c13947c0b72967e7af7 kostenfrei https://www.frontiersin.org/articles/10.3389/falgy.2021.675557/full kostenfrei https://doaj.org/toc/2673-6101 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2021
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allfieldsSound	10.3389/falgy.2021.675557 doi (DE-627)DOAJ058857915 (DE-599)DOAJ0a4481d63f334c13947c0b72967e7af7 DE-627 ger DE-627 rakwb eng RC581-607 Araceli Díaz-Perales verfasserin aut The Role of Sphingolipids in Allergic Disorders 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different human pathologies such as neurological disorders, cancer, autoimmunity, and infections. Sphingolipid metabolites, in particular, ceramide and sphingosine-1-phosphate (S1P), regulate a diverse range of cellular processes that are important in immunity and inflammation. Moreover, variations in the sphingolipid concentrations have been strongly associated with allergic diseases. This review will focus on the role of sphingolipids in the development of allergic sensitization and allergic inflammation through the activation of immune cells resident in tissues, as well as their role in barrier remodeling and anaphylaxis. The knowledge gained in this emerging field will help to develop new therapeutic options for allergic disorders. sphingolipid inflammation allergy sphigosine-1-P ceramide-1-P disruption epithelial barrier Immunologic diseases. Allergy Maria M. Escribese verfasserin aut María Garrido-Arandia verfasserin aut David Obeso verfasserin aut Elena Izquierdo-Alvarez verfasserin aut Jaime Tome-Amat verfasserin aut Domingo Barber verfasserin aut In Frontiers in Allergy Frontiers Media S.A., 2021 2(2021) (DE-627)1757639608 (DE-600)3063831-8 26736101 nnns volume:2 year:2021 https://doi.org/10.3389/falgy.2021.675557 kostenfrei https://doaj.org/article/0a4481d63f334c13947c0b72967e7af7 kostenfrei https://www.frontiersin.org/articles/10.3389/falgy.2021.675557/full kostenfrei https://doaj.org/toc/2673-6101 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2021
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callnumber-first	R - Medicine
author	Araceli Díaz-Perales
spellingShingle	Araceli Díaz-Perales misc RC581-607 misc sphingolipid misc inflammation misc allergy misc sphigosine-1-P misc ceramide-1-P misc disruption epithelial barrier misc Immunologic diseases. Allergy The Role of Sphingolipids in Allergic Disorders
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topic_title	RC581-607 The Role of Sphingolipids in Allergic Disorders sphingolipid inflammation allergy sphigosine-1-P ceramide-1-P disruption epithelial barrier
topic	misc RC581-607 misc sphingolipid misc inflammation misc allergy misc sphigosine-1-P misc ceramide-1-P misc disruption epithelial barrier misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc sphingolipid misc inflammation misc allergy misc sphigosine-1-P misc ceramide-1-P misc disruption epithelial barrier misc Immunologic diseases. Allergy
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title	The Role of Sphingolipids in Allergic Disorders
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title_full	The Role of Sphingolipids in Allergic Disorders
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title_sort	role of sphingolipids in allergic disorders
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title_auth	The Role of Sphingolipids in Allergic Disorders
abstract	Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different human pathologies such as neurological disorders, cancer, autoimmunity, and infections. Sphingolipid metabolites, in particular, ceramide and sphingosine-1-phosphate (S1P), regulate a diverse range of cellular processes that are important in immunity and inflammation. Moreover, variations in the sphingolipid concentrations have been strongly associated with allergic diseases. This review will focus on the role of sphingolipids in the development of allergic sensitization and allergic inflammation through the activation of immune cells resident in tissues, as well as their role in barrier remodeling and anaphylaxis. The knowledge gained in this emerging field will help to develop new therapeutic options for allergic disorders.
abstractGer	Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different human pathologies such as neurological disorders, cancer, autoimmunity, and infections. Sphingolipid metabolites, in particular, ceramide and sphingosine-1-phosphate (S1P), regulate a diverse range of cellular processes that are important in immunity and inflammation. Moreover, variations in the sphingolipid concentrations have been strongly associated with allergic diseases. This review will focus on the role of sphingolipids in the development of allergic sensitization and allergic inflammation through the activation of immune cells resident in tissues, as well as their role in barrier remodeling and anaphylaxis. The knowledge gained in this emerging field will help to develop new therapeutic options for allergic disorders.
abstract_unstemmed	Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different human pathologies such as neurological disorders, cancer, autoimmunity, and infections. Sphingolipid metabolites, in particular, ceramide and sphingosine-1-phosphate (S1P), regulate a diverse range of cellular processes that are important in immunity and inflammation. Moreover, variations in the sphingolipid concentrations have been strongly associated with allergic diseases. This review will focus on the role of sphingolipids in the development of allergic sensitization and allergic inflammation through the activation of immune cells resident in tissues, as well as their role in barrier remodeling and anaphylaxis. The knowledge gained in this emerging field will help to develop new therapeutic options for allergic disorders.
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title_short	The Role of Sphingolipids in Allergic Disorders
url	https://doi.org/10.3389/falgy.2021.675557 https://doaj.org/article/0a4481d63f334c13947c0b72967e7af7 https://www.frontiersin.org/articles/10.3389/falgy.2021.675557/full https://doaj.org/toc/2673-6101
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