Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells

Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic ac...
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Autor*in:	Angela Costagliola di Polidoro [verfasserIn] Giorgia Zambito [verfasserIn] Joost Haeck [verfasserIn] Laura Mezzanotte [verfasserIn] Martine Lamfers [verfasserIn] Paolo Antonio Netti [verfasserIn] Enza Torino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	glioblastoma theranostics angiopep-2 BBB active targeting irinotecan

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 3, p 503
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:3, p 503

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13030503

Katalog-ID:	DOAJ058876111

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allfields	10.3390/cancers13030503 doi (DE-627)DOAJ058876111 (DE-599)DOAJea2c1780cef044bc8df0a3bf7d6544ca DE-627 ger DE-627 rakwb eng RC254-282 Angela Costagliola di Polidoro verfasserin aut Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h. glioblastoma theranostics angiopep-2 BBB active targeting irinotecan Neoplasms. Tumors. Oncology. Including cancer and carcinogens Giorgia Zambito verfasserin aut Joost Haeck verfasserin aut Laura Mezzanotte verfasserin aut Martine Lamfers verfasserin aut Paolo Antonio Netti verfasserin aut Enza Torino verfasserin aut In Cancers MDPI AG, 2010 13(2021), 3, p 503 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:3, p 503 https://doi.org/10.3390/cancers13030503 kostenfrei https://doaj.org/article/ea2c1780cef044bc8df0a3bf7d6544ca kostenfrei https://www.mdpi.com/2072-6694/13/3/503 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 503
spelling	10.3390/cancers13030503 doi (DE-627)DOAJ058876111 (DE-599)DOAJea2c1780cef044bc8df0a3bf7d6544ca DE-627 ger DE-627 rakwb eng RC254-282 Angela Costagliola di Polidoro verfasserin aut Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h. glioblastoma theranostics angiopep-2 BBB active targeting irinotecan Neoplasms. Tumors. Oncology. Including cancer and carcinogens Giorgia Zambito verfasserin aut Joost Haeck verfasserin aut Laura Mezzanotte verfasserin aut Martine Lamfers verfasserin aut Paolo Antonio Netti verfasserin aut Enza Torino verfasserin aut In Cancers MDPI AG, 2010 13(2021), 3, p 503 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:3, p 503 https://doi.org/10.3390/cancers13030503 kostenfrei https://doaj.org/article/ea2c1780cef044bc8df0a3bf7d6544ca kostenfrei https://www.mdpi.com/2072-6694/13/3/503 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 503
allfields_unstemmed	10.3390/cancers13030503 doi (DE-627)DOAJ058876111 (DE-599)DOAJea2c1780cef044bc8df0a3bf7d6544ca DE-627 ger DE-627 rakwb eng RC254-282 Angela Costagliola di Polidoro verfasserin aut Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h. glioblastoma theranostics angiopep-2 BBB active targeting irinotecan Neoplasms. Tumors. Oncology. Including cancer and carcinogens Giorgia Zambito verfasserin aut Joost Haeck verfasserin aut Laura Mezzanotte verfasserin aut Martine Lamfers verfasserin aut Paolo Antonio Netti verfasserin aut Enza Torino verfasserin aut In Cancers MDPI AG, 2010 13(2021), 3, p 503 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:3, p 503 https://doi.org/10.3390/cancers13030503 kostenfrei https://doaj.org/article/ea2c1780cef044bc8df0a3bf7d6544ca kostenfrei https://www.mdpi.com/2072-6694/13/3/503 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 503
allfieldsGer	10.3390/cancers13030503 doi (DE-627)DOAJ058876111 (DE-599)DOAJea2c1780cef044bc8df0a3bf7d6544ca DE-627 ger DE-627 rakwb eng RC254-282 Angela Costagliola di Polidoro verfasserin aut Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h. glioblastoma theranostics angiopep-2 BBB active targeting irinotecan Neoplasms. Tumors. Oncology. Including cancer and carcinogens Giorgia Zambito verfasserin aut Joost Haeck verfasserin aut Laura Mezzanotte verfasserin aut Martine Lamfers verfasserin aut Paolo Antonio Netti verfasserin aut Enza Torino verfasserin aut In Cancers MDPI AG, 2010 13(2021), 3, p 503 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:3, p 503 https://doi.org/10.3390/cancers13030503 kostenfrei https://doaj.org/article/ea2c1780cef044bc8df0a3bf7d6544ca kostenfrei https://www.mdpi.com/2072-6694/13/3/503 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 503
allfieldsSound	10.3390/cancers13030503 doi (DE-627)DOAJ058876111 (DE-599)DOAJea2c1780cef044bc8df0a3bf7d6544ca DE-627 ger DE-627 rakwb eng RC254-282 Angela Costagliola di Polidoro verfasserin aut Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h. glioblastoma theranostics angiopep-2 BBB active targeting irinotecan Neoplasms. Tumors. Oncology. Including cancer and carcinogens Giorgia Zambito verfasserin aut Joost Haeck verfasserin aut Laura Mezzanotte verfasserin aut Martine Lamfers verfasserin aut Paolo Antonio Netti verfasserin aut Enza Torino verfasserin aut In Cancers MDPI AG, 2010 13(2021), 3, p 503 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:3, p 503 https://doi.org/10.3390/cancers13030503 kostenfrei https://doaj.org/article/ea2c1780cef044bc8df0a3bf7d6544ca kostenfrei https://www.mdpi.com/2072-6694/13/3/503 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 503
language	English
source	In Cancers 13(2021), 3, p 503 volume:13 year:2021 number:3, p 503
sourceStr	In Cancers 13(2021), 3, p 503 volume:13 year:2021 number:3, p 503
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	glioblastoma theranostics angiopep-2 BBB active targeting irinotecan Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Angela Costagliola di Polidoro @@aut@@ Giorgia Zambito @@aut@@ Joost Haeck @@aut@@ Laura Mezzanotte @@aut@@ Martine Lamfers @@aut@@ Paolo Antonio Netti @@aut@@ Enza Torino @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Angela Costagliola di Polidoro
spellingShingle	Angela Costagliola di Polidoro misc RC254-282 misc glioblastoma misc theranostics misc angiopep-2 misc BBB misc active targeting misc irinotecan misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells
authorStr	Angela Costagliola di Polidoro
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issn	20726694
topic_title	RC254-282 Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells glioblastoma theranostics angiopep-2 BBB active targeting irinotecan
topic	misc RC254-282 misc glioblastoma misc theranostics misc angiopep-2 misc BBB misc active targeting misc irinotecan misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc glioblastoma misc theranostics misc angiopep-2 misc BBB misc active targeting misc irinotecan misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc glioblastoma misc theranostics misc angiopep-2 misc BBB misc active targeting misc irinotecan misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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hierarchy_parent_title	Cancers
hierarchy_parent_id	614095670
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title	Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells
ctrlnum	(DE-627)DOAJ058876111 (DE-599)DOAJea2c1780cef044bc8df0a3bf7d6544ca
title_full	Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells
author_sort	Angela Costagliola di Polidoro
journal	Cancers
journalStr	Cancers
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lang_code	eng
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author_browse	Angela Costagliola di Polidoro Giorgia Zambito Joost Haeck Laura Mezzanotte Martine Lamfers Paolo Antonio Netti Enza Torino
container_volume	13
class	RC254-282
format_se	Elektronische Aufsätze
author-letter	Angela Costagliola di Polidoro
doi_str_mv	10.3390/cancers13030503
author2-role	verfasserin
title_sort	theranostic design of angiopep-2 conjugated hyaluronic acid nanoparticles (thera-ang-chanps) for dual targeting and boosted imaging of glioma cells
callnumber	RC254-282
title_auth	Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells
abstract	Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h.
abstractGer	Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h.
abstract_unstemmed	Glioblastoma multiforme (GBM) has a mean survival of only 15 months. Tumour heterogeneity and blood-brain barrier (BBB) mainly hinder the transport of active agents, leading to late diagnosis, ineffective therapy and inaccurate follow-up. The use of hydrogel nanoparticles, particularly hyaluronic acid as naturally occurring polymer of the extracellular matrix (ECM), has great potential in improving the transport of drug molecules and, furthermore, in facilitatating the early diagnosis by the effect of hydrodenticity enabling the T<sub<1</sub< boosting of Gadolinium chelates for MRI. Here, crosslinked hyaluronic acid nanoparticles encapsulating gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and the chemotherapeutic agent irinotecan (Thera-cHANPs) are proposed as theranostic nanovectors, with improved MRI capacities. Irinotecan was selected since currently repurposed as an alternative compound to the poorly effective temozolomide (TMZ), generally approved as the gold standard in GBM clinical care. Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. Results showed preserving the hydrodenticity effect in the advanced formulation and internalization by the active peptide-mediated uptake of Thera-cHANPs in U87 and GS-102 cells. Moreover, Thera-ANG-cHANPs proved to reduce ironotecan time response, showing a significant cytotoxic effect in 24 h instead of 48 h.
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container_issue	3, p 503
title_short	Theranostic Design of Angiopep-2 Conjugated Hyaluronic Acid Nanoparticles (Thera-ANG-cHANPs) for Dual Targeting and Boosted Imaging of Glioma Cells
url	https://doi.org/10.3390/cancers13030503 https://doaj.org/article/ea2c1780cef044bc8df0a3bf7d6544ca https://www.mdpi.com/2072-6694/13/3/503 https://doaj.org/toc/2072-6694
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author2	Giorgia Zambito Joost Haeck Laura Mezzanotte Martine Lamfers Paolo Antonio Netti Enza Torino
author2Str	Giorgia Zambito Joost Haeck Laura Mezzanotte Martine Lamfers Paolo Antonio Netti Enza Torino
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doi_str	10.3390/cancers13030503
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up_date	2024-07-03T20:33:22.368Z
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