Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned?

Historically, knowledge of human host–enteric pathogen interactions has been elucidated from studies using cancer cells, animal models, clinical data, and occasionally, controlled human infection models. Although much has been learned from these studies, an understanding of the complex interactions...
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Autor*in:	Sue E. Crawford [verfasserIn] Sasirekha Ramani [verfasserIn] Sarah E. Blutt [verfasserIn] Mary K. Estes [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	enteric virus human intestinal organoid enteroid gastrointestinal infection diarrhea host–virus interactions

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 13(2021), 6, p 999
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:6, p 999

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v13060999

Katalog-ID:	DOAJ058941126

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allfieldsSound	10.3390/v13060999 doi (DE-627)DOAJ058941126 (DE-599)DOAJf47410eabc1848599bceaa9a4250f837 DE-627 ger DE-627 rakwb eng QR1-502 Sue E. Crawford verfasserin aut Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Historically, knowledge of human host–enteric pathogen interactions has been elucidated from studies using cancer cells, animal models, clinical data, and occasionally, controlled human infection models. Although much has been learned from these studies, an understanding of the complex interactions between human viruses and the human intestinal epithelium was initially limited by the lack of nontransformed culture systems, which recapitulate the relevant heterogenous cell types that comprise the intestinal villus epithelium. New investigations using multicellular, physiologically active, organotypic cultures produced from intestinal stem cells isolated from biopsies or surgical specimens provide an exciting new avenue for understanding human specific pathogens and revealing previously unknown host–microbe interactions that affect replication and outcomes of human infections. Here, we summarize recent biologic discoveries using human intestinal organoids and human enteric viral pathogens. enteric virus human intestinal organoid enteroid gastrointestinal infection diarrhea host–virus interactions Microbiology Sasirekha Ramani verfasserin aut Sarah E. Blutt verfasserin aut Mary K. Estes verfasserin aut In Viruses MDPI AG, 2009 13(2021), 6, p 999 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:13 year:2021 number:6, p 999 https://doi.org/10.3390/v13060999 kostenfrei https://doaj.org/article/f47410eabc1848599bceaa9a4250f837 kostenfrei https://www.mdpi.com/1999-4915/13/6/999 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6, p 999
language	English
source	In Viruses 13(2021), 6, p 999 volume:13 year:2021 number:6, p 999
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topic_facet	enteric virus human intestinal organoid enteroid gastrointestinal infection diarrhea host–virus interactions Microbiology
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authorswithroles_txt_mv	Sue E. Crawford @@aut@@ Sasirekha Ramani @@aut@@ Sarah E. Blutt @@aut@@ Mary K. Estes @@aut@@
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callnumber-first	Q - Science
author	Sue E. Crawford
spellingShingle	Sue E. Crawford misc QR1-502 misc enteric virus misc human intestinal organoid misc enteroid misc gastrointestinal infection misc diarrhea misc host–virus interactions misc Microbiology Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned?
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topic_title	QR1-502 Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned? enteric virus human intestinal organoid enteroid gastrointestinal infection diarrhea host–virus interactions
topic	misc QR1-502 misc enteric virus misc human intestinal organoid misc enteroid misc gastrointestinal infection misc diarrhea misc host–virus interactions misc Microbiology
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title_sort	organoids to dissect gastrointestinal virus–host interactions: what have we learned?
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title_auth	Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned?
abstract	Historically, knowledge of human host–enteric pathogen interactions has been elucidated from studies using cancer cells, animal models, clinical data, and occasionally, controlled human infection models. Although much has been learned from these studies, an understanding of the complex interactions between human viruses and the human intestinal epithelium was initially limited by the lack of nontransformed culture systems, which recapitulate the relevant heterogenous cell types that comprise the intestinal villus epithelium. New investigations using multicellular, physiologically active, organotypic cultures produced from intestinal stem cells isolated from biopsies or surgical specimens provide an exciting new avenue for understanding human specific pathogens and revealing previously unknown host–microbe interactions that affect replication and outcomes of human infections. Here, we summarize recent biologic discoveries using human intestinal organoids and human enteric viral pathogens.
abstractGer	Historically, knowledge of human host–enteric pathogen interactions has been elucidated from studies using cancer cells, animal models, clinical data, and occasionally, controlled human infection models. Although much has been learned from these studies, an understanding of the complex interactions between human viruses and the human intestinal epithelium was initially limited by the lack of nontransformed culture systems, which recapitulate the relevant heterogenous cell types that comprise the intestinal villus epithelium. New investigations using multicellular, physiologically active, organotypic cultures produced from intestinal stem cells isolated from biopsies or surgical specimens provide an exciting new avenue for understanding human specific pathogens and revealing previously unknown host–microbe interactions that affect replication and outcomes of human infections. Here, we summarize recent biologic discoveries using human intestinal organoids and human enteric viral pathogens.
abstract_unstemmed	Historically, knowledge of human host–enteric pathogen interactions has been elucidated from studies using cancer cells, animal models, clinical data, and occasionally, controlled human infection models. Although much has been learned from these studies, an understanding of the complex interactions between human viruses and the human intestinal epithelium was initially limited by the lack of nontransformed culture systems, which recapitulate the relevant heterogenous cell types that comprise the intestinal villus epithelium. New investigations using multicellular, physiologically active, organotypic cultures produced from intestinal stem cells isolated from biopsies or surgical specimens provide an exciting new avenue for understanding human specific pathogens and revealing previously unknown host–microbe interactions that affect replication and outcomes of human infections. Here, we summarize recent biologic discoveries using human intestinal organoids and human enteric viral pathogens.
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title_short	Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned?
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