Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients

Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was...
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Autor*in:	Marziye Taheri [verfasserIn] Moein Saleh [verfasserIn] Amir Hesam Nemati [verfasserIn] Mehdi Ariana [verfasserIn] Esfandiar Shojaei [verfasserIn] Masoud Mardani [verfasserIn] Mohammad Katouli [verfasserIn] Mohammad Pooya [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance

Übergeordnetes Werk:	In: Journal of Medical Microbiology and Infectious Diseases - Pasteur Institute of Iran, 2021, 4(2016), 3, Seite 76-82
Übergeordnetes Werk:	volume:4 ; year:2016 ; number:3 ; pages:76-82

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ059033193

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520			\|a Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs.
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700	0		\|a Mohammad Pooya \|e verfasserin \|4 aut
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allfields	(DE-627)DOAJ059033193 (DE-599)DOAJ9fb5efb0fade47a4a13b8410585671f1 DE-627 ger DE-627 rakwb eng RB1-214 Marziye Taheri verfasserin aut Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs. catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance Pathology Moein Saleh verfasserin aut Amir Hesam Nemati verfasserin aut Mehdi Ariana verfasserin aut Esfandiar Shojaei verfasserin aut Masoud Mardani verfasserin aut Mohammad Katouli verfasserin aut Mohammad Pooya verfasserin aut In Journal of Medical Microbiology and Infectious Diseases Pasteur Institute of Iran, 2021 4(2016), 3, Seite 76-82 (DE-627)1692878484 23455330 nnns volume:4 year:2016 number:3 pages:76-82 https://doaj.org/article/9fb5efb0fade47a4a13b8410585671f1 kostenfrei http://jommid.pasteur.ac.ir/article-1-135-en.html kostenfrei https://doaj.org/toc/2345-5349 Journal toc kostenfrei https://doaj.org/toc/2345-5330 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2016 3 76-82
spelling	(DE-627)DOAJ059033193 (DE-599)DOAJ9fb5efb0fade47a4a13b8410585671f1 DE-627 ger DE-627 rakwb eng RB1-214 Marziye Taheri verfasserin aut Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs. catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance Pathology Moein Saleh verfasserin aut Amir Hesam Nemati verfasserin aut Mehdi Ariana verfasserin aut Esfandiar Shojaei verfasserin aut Masoud Mardani verfasserin aut Mohammad Katouli verfasserin aut Mohammad Pooya verfasserin aut In Journal of Medical Microbiology and Infectious Diseases Pasteur Institute of Iran, 2021 4(2016), 3, Seite 76-82 (DE-627)1692878484 23455330 nnns volume:4 year:2016 number:3 pages:76-82 https://doaj.org/article/9fb5efb0fade47a4a13b8410585671f1 kostenfrei http://jommid.pasteur.ac.ir/article-1-135-en.html kostenfrei https://doaj.org/toc/2345-5349 Journal toc kostenfrei https://doaj.org/toc/2345-5330 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2016 3 76-82
allfields_unstemmed	(DE-627)DOAJ059033193 (DE-599)DOAJ9fb5efb0fade47a4a13b8410585671f1 DE-627 ger DE-627 rakwb eng RB1-214 Marziye Taheri verfasserin aut Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs. catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance Pathology Moein Saleh verfasserin aut Amir Hesam Nemati verfasserin aut Mehdi Ariana verfasserin aut Esfandiar Shojaei verfasserin aut Masoud Mardani verfasserin aut Mohammad Katouli verfasserin aut Mohammad Pooya verfasserin aut In Journal of Medical Microbiology and Infectious Diseases Pasteur Institute of Iran, 2021 4(2016), 3, Seite 76-82 (DE-627)1692878484 23455330 nnns volume:4 year:2016 number:3 pages:76-82 https://doaj.org/article/9fb5efb0fade47a4a13b8410585671f1 kostenfrei http://jommid.pasteur.ac.ir/article-1-135-en.html kostenfrei https://doaj.org/toc/2345-5349 Journal toc kostenfrei https://doaj.org/toc/2345-5330 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2016 3 76-82
allfieldsGer	(DE-627)DOAJ059033193 (DE-599)DOAJ9fb5efb0fade47a4a13b8410585671f1 DE-627 ger DE-627 rakwb eng RB1-214 Marziye Taheri verfasserin aut Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs. catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance Pathology Moein Saleh verfasserin aut Amir Hesam Nemati verfasserin aut Mehdi Ariana verfasserin aut Esfandiar Shojaei verfasserin aut Masoud Mardani verfasserin aut Mohammad Katouli verfasserin aut Mohammad Pooya verfasserin aut In Journal of Medical Microbiology and Infectious Diseases Pasteur Institute of Iran, 2021 4(2016), 3, Seite 76-82 (DE-627)1692878484 23455330 nnns volume:4 year:2016 number:3 pages:76-82 https://doaj.org/article/9fb5efb0fade47a4a13b8410585671f1 kostenfrei http://jommid.pasteur.ac.ir/article-1-135-en.html kostenfrei https://doaj.org/toc/2345-5349 Journal toc kostenfrei https://doaj.org/toc/2345-5330 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2016 3 76-82
allfieldsSound	(DE-627)DOAJ059033193 (DE-599)DOAJ9fb5efb0fade47a4a13b8410585671f1 DE-627 ger DE-627 rakwb eng RB1-214 Marziye Taheri verfasserin aut Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs. catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance Pathology Moein Saleh verfasserin aut Amir Hesam Nemati verfasserin aut Mehdi Ariana verfasserin aut Esfandiar Shojaei verfasserin aut Masoud Mardani verfasserin aut Mohammad Katouli verfasserin aut Mohammad Pooya verfasserin aut In Journal of Medical Microbiology and Infectious Diseases Pasteur Institute of Iran, 2021 4(2016), 3, Seite 76-82 (DE-627)1692878484 23455330 nnns volume:4 year:2016 number:3 pages:76-82 https://doaj.org/article/9fb5efb0fade47a4a13b8410585671f1 kostenfrei http://jommid.pasteur.ac.ir/article-1-135-en.html kostenfrei https://doaj.org/toc/2345-5349 Journal toc kostenfrei https://doaj.org/toc/2345-5330 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2016 3 76-82
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source	In Journal of Medical Microbiology and Infectious Diseases 4(2016), 3, Seite 76-82 volume:4 year:2016 number:3 pages:76-82
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topic_facet	catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance Pathology
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authorswithroles_txt_mv	Marziye Taheri @@aut@@ Moein Saleh @@aut@@ Amir Hesam Nemati @@aut@@ Mehdi Ariana @@aut@@ Esfandiar Shojaei @@aut@@ Masoud Mardani @@aut@@ Mohammad Katouli @@aut@@ Mohammad Pooya @@aut@@
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callnumber-first	R - Medicine
author	Marziye Taheri
spellingShingle	Marziye Taheri misc RB1-214 misc catheter-related infections misc uropathogenic escherichia coli misc bacterial drug resistance misc multiple drug resistance misc beta-lactam resistance misc Pathology Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients
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topic_title	RB1-214 Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients catheter-related infections uropathogenic escherichia coli bacterial drug resistance multiple drug resistance beta-lactam resistance
topic	misc RB1-214 misc catheter-related infections misc uropathogenic escherichia coli misc bacterial drug resistance misc multiple drug resistance misc beta-lactam resistance misc Pathology
topic_unstemmed	misc RB1-214 misc catheter-related infections misc uropathogenic escherichia coli misc bacterial drug resistance misc multiple drug resistance misc beta-lactam resistance misc Pathology
topic_browse	misc RB1-214 misc catheter-related infections misc uropathogenic escherichia coli misc bacterial drug resistance misc multiple drug resistance misc beta-lactam resistance misc Pathology
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title	Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients
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title_full	Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients
author_sort	Marziye Taheri
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author_browse	Marziye Taheri Moein Saleh Amir Hesam Nemati Mehdi Ariana Esfandiar Shojaei Masoud Mardani Mohammad Katouli Mohammad Pooya
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title_sort	antibiotic resistance pattern and phylogenetic groups of the uropathogenic escherichia coli isolates recovered from the urinary catheters of the hospitalized patients
callnumber	RB1-214
title_auth	Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients
abstract	Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs.
abstractGer	Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs.
abstract_unstemmed	Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs.
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title_short	Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients
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Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. 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Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients

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