Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer

Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, gr...
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Autor*in:	Chia-Jung Li [verfasserIn] Yen-Dun Tony Tzeng [verfasserIn] Yi-Han Chiu [verfasserIn] Hung-Yu Lin [verfasserIn] Ming-Feng Hou [verfasserIn] Pei-Yi Chu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	breast cancer target therapy biomarkers pathogenesis

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 12, p 2978
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:12, p 2978

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13122978

Katalog-ID:	DOAJ059059710

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520			\|a Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.
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allfieldsSound	10.3390/cancers13122978 doi (DE-627)DOAJ059059710 (DE-599)DOAJ4c45f842eb0b4feca1f2443e61cd736a DE-627 ger DE-627 rakwb eng RC254-282 Chia-Jung Li verfasserin aut Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies. breast cancer target therapy biomarkers pathogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yen-Dun Tony Tzeng verfasserin aut Yi-Han Chiu verfasserin aut Hung-Yu Lin verfasserin aut Ming-Feng Hou verfasserin aut Pei-Yi Chu verfasserin aut In Cancers MDPI AG, 2010 13(2021), 12, p 2978 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:12, p 2978 https://doi.org/10.3390/cancers13122978 kostenfrei https://doaj.org/article/4c45f842eb0b4feca1f2443e61cd736a kostenfrei https://www.mdpi.com/2072-6694/13/12/2978 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 12, p 2978
language	English
source	In Cancers 13(2021), 12, p 2978 volume:13 year:2021 number:12, p 2978
sourceStr	In Cancers 13(2021), 12, p 2978 volume:13 year:2021 number:12, p 2978
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	breast cancer target therapy biomarkers pathogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Chia-Jung Li @@aut@@ Yen-Dun Tony Tzeng @@aut@@ Yi-Han Chiu @@aut@@ Hung-Yu Lin @@aut@@ Ming-Feng Hou @@aut@@ Pei-Yi Chu @@aut@@
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callnumber-first	R - Medicine
author	Chia-Jung Li
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topic_title	RC254-282 Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer breast cancer target therapy biomarkers pathogenesis
topic	misc RC254-282 misc breast cancer misc target therapy misc biomarkers misc pathogenesis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title_sort	pathogenesis and potential therapeutic targets for triple-negative breast cancer
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title_auth	Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer
abstract	Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.
abstractGer	Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.
abstract_unstemmed	Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.
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title_short	Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer
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