Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice

In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham...
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Autor*in:	A.C. Casquero [verfasserIn] J.A. Berti [verfasserIn] A.G. Salerno [verfasserIn] E.J.B. Bighetti [verfasserIn] P.M. Cazita [verfasserIn] D.F.J. Ketelhuth [verfasserIn] M. Gidlund [verfasserIn] H.C.F. Oliveira [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2006

Schlagwörter:	low density lipoprotein receptor lipoprotein lipase lipolysis plasma lipoprotein kinetics oxidized low density lipoprotein aortic atherosclerosis lesion

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 47(2006), 7, Seite 1526-1534
Übergeordnetes Werk:	volume:47 ; year:2006 ; number:7 ; pages:1526-1534

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M600135-JLR200

Katalog-ID:	DOAJ059101091

Internformat


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spelling	10.1194/jlr.M600135-JLR200 doi (DE-627)DOAJ059101091 (DE-599)DOAJ13b1e3184da44b37af56abbec1569066 DE-627 ger DE-627 rakwb eng QD415-436 A.C. Casquero verfasserin aut Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham operation. Castrated mice had an increase in the LDL fraction (+36% for CETP and +79% for nTg mice), whereas the HDL fraction was reduced (−30% for CETP and −11% for nTg mice). Castrated mice presented 1.7-fold higher titers of anti-oxidized LDL (Ox-LDL) antibodies than sham-operated controls. Plasma levels of CETP, lipoprotein lipase, and hepatic lipase were not changed by castration. Kinetic studies showed no differences in VLDL secretion rate, VLDL-LDL conversion rate, or number of LDL and HDL receptors. Competition experiments showed lower affinity of LDL from castrated mice for tissue receptors. Diet-induced atherosclerosis studies showed that testosterone deficiency increased by 100%, and CETP expression reduced by 44%, the size of aortic lesion area in castrated mice. In summary, testosterone deficiency increased plasma levels of apolipoprotein B-containing lipoproteins (apoB-LPs) and anti-OxLDL antibodies, decreased LDL receptor affinity, and doubled the size of diet-induced atherosclerotic lesions. The expression of CETP led to a milder increase of apoB-LPs and reduced atherosclerotic lesion size in testosterone-deficient mice. low density lipoprotein receptor lipoprotein lipase lipolysis plasma lipoprotein kinetics oxidized low density lipoprotein aortic atherosclerosis lesion Biochemistry J.A. Berti verfasserin aut A.G. Salerno verfasserin aut E.J.B. Bighetti verfasserin aut P.M. Cazita verfasserin aut D.F.J. Ketelhuth verfasserin aut M. Gidlund verfasserin aut H.C.F. Oliveira verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 7, Seite 1526-1534 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:7 pages:1526-1534 https://doi.org/10.1194/jlr.M600135-JLR200 kostenfrei https://doaj.org/article/13b1e3184da44b37af56abbec1569066 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520331977 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 7 1526-1534
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allfieldsSound	10.1194/jlr.M600135-JLR200 doi (DE-627)DOAJ059101091 (DE-599)DOAJ13b1e3184da44b37af56abbec1569066 DE-627 ger DE-627 rakwb eng QD415-436 A.C. Casquero verfasserin aut Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham operation. Castrated mice had an increase in the LDL fraction (+36% for CETP and +79% for nTg mice), whereas the HDL fraction was reduced (−30% for CETP and −11% for nTg mice). Castrated mice presented 1.7-fold higher titers of anti-oxidized LDL (Ox-LDL) antibodies than sham-operated controls. Plasma levels of CETP, lipoprotein lipase, and hepatic lipase were not changed by castration. Kinetic studies showed no differences in VLDL secretion rate, VLDL-LDL conversion rate, or number of LDL and HDL receptors. Competition experiments showed lower affinity of LDL from castrated mice for tissue receptors. Diet-induced atherosclerosis studies showed that testosterone deficiency increased by 100%, and CETP expression reduced by 44%, the size of aortic lesion area in castrated mice. In summary, testosterone deficiency increased plasma levels of apolipoprotein B-containing lipoproteins (apoB-LPs) and anti-OxLDL antibodies, decreased LDL receptor affinity, and doubled the size of diet-induced atherosclerotic lesions. The expression of CETP led to a milder increase of apoB-LPs and reduced atherosclerotic lesion size in testosterone-deficient mice. low density lipoprotein receptor lipoprotein lipase lipolysis plasma lipoprotein kinetics oxidized low density lipoprotein aortic atherosclerosis lesion Biochemistry J.A. Berti verfasserin aut A.G. Salerno verfasserin aut E.J.B. Bighetti verfasserin aut P.M. Cazita verfasserin aut D.F.J. Ketelhuth verfasserin aut M. Gidlund verfasserin aut H.C.F. Oliveira verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 7, Seite 1526-1534 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:7 pages:1526-1534 https://doi.org/10.1194/jlr.M600135-JLR200 kostenfrei https://doaj.org/article/13b1e3184da44b37af56abbec1569066 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520331977 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 7 1526-1534
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Casquero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2006</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. 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author	A.C. Casquero
spellingShingle	A.C. Casquero misc QD415-436 misc low density lipoprotein receptor misc lipoprotein lipase misc lipolysis misc plasma lipoprotein kinetics misc oxidized low density lipoprotein misc aortic atherosclerosis lesion misc Biochemistry Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice
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topic_title	QD415-436 Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice low density lipoprotein receptor lipoprotein lipase lipolysis plasma lipoprotein kinetics oxidized low density lipoprotein aortic atherosclerosis lesion
topic	misc QD415-436 misc low density lipoprotein receptor misc lipoprotein lipase misc lipolysis misc plasma lipoprotein kinetics misc oxidized low density lipoprotein misc aortic atherosclerosis lesion misc Biochemistry
topic_unstemmed	misc QD415-436 misc low density lipoprotein receptor misc lipoprotein lipase misc lipolysis misc plasma lipoprotein kinetics misc oxidized low density lipoprotein misc aortic atherosclerosis lesion misc Biochemistry
topic_browse	misc QD415-436 misc low density lipoprotein receptor misc lipoprotein lipase misc lipolysis misc plasma lipoprotein kinetics misc oxidized low density lipoprotein misc aortic atherosclerosis lesion misc Biochemistry
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title	Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice
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title_full	Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice
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author_browse	A.C. Casquero J.A. Berti A.G. Salerno E.J.B. Bighetti P.M. Cazita D.F.J. Ketelhuth M. Gidlund H.C.F. Oliveira
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title_sort	atherosclerosis is enhanced by testosterone deficiency and attenuated by cetp expression in transgenic mice
callnumber	QD415-436
title_auth	Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice
abstract	In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham operation. Castrated mice had an increase in the LDL fraction (+36% for CETP and +79% for nTg mice), whereas the HDL fraction was reduced (−30% for CETP and −11% for nTg mice). Castrated mice presented 1.7-fold higher titers of anti-oxidized LDL (Ox-LDL) antibodies than sham-operated controls. Plasma levels of CETP, lipoprotein lipase, and hepatic lipase were not changed by castration. Kinetic studies showed no differences in VLDL secretion rate, VLDL-LDL conversion rate, or number of LDL and HDL receptors. Competition experiments showed lower affinity of LDL from castrated mice for tissue receptors. Diet-induced atherosclerosis studies showed that testosterone deficiency increased by 100%, and CETP expression reduced by 44%, the size of aortic lesion area in castrated mice. In summary, testosterone deficiency increased plasma levels of apolipoprotein B-containing lipoproteins (apoB-LPs) and anti-OxLDL antibodies, decreased LDL receptor affinity, and doubled the size of diet-induced atherosclerotic lesions. The expression of CETP led to a milder increase of apoB-LPs and reduced atherosclerotic lesion size in testosterone-deficient mice.
abstractGer	In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham operation. Castrated mice had an increase in the LDL fraction (+36% for CETP and +79% for nTg mice), whereas the HDL fraction was reduced (−30% for CETP and −11% for nTg mice). Castrated mice presented 1.7-fold higher titers of anti-oxidized LDL (Ox-LDL) antibodies than sham-operated controls. Plasma levels of CETP, lipoprotein lipase, and hepatic lipase were not changed by castration. Kinetic studies showed no differences in VLDL secretion rate, VLDL-LDL conversion rate, or number of LDL and HDL receptors. Competition experiments showed lower affinity of LDL from castrated mice for tissue receptors. Diet-induced atherosclerosis studies showed that testosterone deficiency increased by 100%, and CETP expression reduced by 44%, the size of aortic lesion area in castrated mice. In summary, testosterone deficiency increased plasma levels of apolipoprotein B-containing lipoproteins (apoB-LPs) and anti-OxLDL antibodies, decreased LDL receptor affinity, and doubled the size of diet-induced atherosclerotic lesions. The expression of CETP led to a milder increase of apoB-LPs and reduced atherosclerotic lesion size in testosterone-deficient mice.
abstract_unstemmed	In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham operation. Castrated mice had an increase in the LDL fraction (+36% for CETP and +79% for nTg mice), whereas the HDL fraction was reduced (−30% for CETP and −11% for nTg mice). Castrated mice presented 1.7-fold higher titers of anti-oxidized LDL (Ox-LDL) antibodies than sham-operated controls. Plasma levels of CETP, lipoprotein lipase, and hepatic lipase were not changed by castration. Kinetic studies showed no differences in VLDL secretion rate, VLDL-LDL conversion rate, or number of LDL and HDL receptors. Competition experiments showed lower affinity of LDL from castrated mice for tissue receptors. Diet-induced atherosclerosis studies showed that testosterone deficiency increased by 100%, and CETP expression reduced by 44%, the size of aortic lesion area in castrated mice. In summary, testosterone deficiency increased plasma levels of apolipoprotein B-containing lipoproteins (apoB-LPs) and anti-OxLDL antibodies, decreased LDL receptor affinity, and doubled the size of diet-induced atherosclerotic lesions. The expression of CETP led to a milder increase of apoB-LPs and reduced atherosclerotic lesion size in testosterone-deficient mice.
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title_short	Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice
url	https://doi.org/10.1194/jlr.M600135-JLR200 https://doaj.org/article/13b1e3184da44b37af56abbec1569066 http://www.sciencedirect.com/science/article/pii/S0022227520331977 https://doaj.org/toc/0022-2275
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up_date	2024-07-03T21:46:25.126Z
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Casquero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2006</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. 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In summary, testosterone deficiency increased plasma levels of apolipoprotein B-containing lipoproteins (apoB-LPs) and anti-OxLDL antibodies, decreased LDL receptor affinity, and doubled the size of diet-induced atherosclerotic lesions. 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Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice

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