Carotid Beta Stiffness Association with Thyroid Function

Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level...
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Autor*in:	Alessandro P. Delitala [verfasserIn] Angelo Scuteri [verfasserIn] Edoardo Fiorillo [verfasserIn] Valeria Orrù [verfasserIn] Edward G. Lakatta [verfasserIn] David Schlessinger [verfasserIn] Francesco Cucca [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	thyroxine carotid beta stiffness aging carotid strain thyroid hormone heart rate

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 3, p 420
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:3, p 420

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10030420

Katalog-ID:	DOAJ059143088

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520			\|a Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate.
650		4	\|a thyroxine
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allfields	10.3390/jcm10030420 doi (DE-627)DOAJ059143088 (DE-599)DOAJaf2db2405929477e9fdf1a81d4a3106d DE-627 ger DE-627 rakwb eng Alessandro P. Delitala verfasserin aut Carotid Beta Stiffness Association with Thyroid Function 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate. thyroxine carotid beta stiffness aging carotid strain thyroid hormone heart rate Medicine R Angelo Scuteri verfasserin aut Edoardo Fiorillo verfasserin aut Valeria Orrù verfasserin aut Edward G. Lakatta verfasserin aut David Schlessinger verfasserin aut Francesco Cucca verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 420 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 420 https://doi.org/10.3390/jcm10030420 kostenfrei https://doaj.org/article/af2db2405929477e9fdf1a81d4a3106d kostenfrei https://www.mdpi.com/2077-0383/10/3/420 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 420
spelling	10.3390/jcm10030420 doi (DE-627)DOAJ059143088 (DE-599)DOAJaf2db2405929477e9fdf1a81d4a3106d DE-627 ger DE-627 rakwb eng Alessandro P. Delitala verfasserin aut Carotid Beta Stiffness Association with Thyroid Function 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate. thyroxine carotid beta stiffness aging carotid strain thyroid hormone heart rate Medicine R Angelo Scuteri verfasserin aut Edoardo Fiorillo verfasserin aut Valeria Orrù verfasserin aut Edward G. Lakatta verfasserin aut David Schlessinger verfasserin aut Francesco Cucca verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 420 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 420 https://doi.org/10.3390/jcm10030420 kostenfrei https://doaj.org/article/af2db2405929477e9fdf1a81d4a3106d kostenfrei https://www.mdpi.com/2077-0383/10/3/420 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 420
allfields_unstemmed	10.3390/jcm10030420 doi (DE-627)DOAJ059143088 (DE-599)DOAJaf2db2405929477e9fdf1a81d4a3106d DE-627 ger DE-627 rakwb eng Alessandro P. Delitala verfasserin aut Carotid Beta Stiffness Association with Thyroid Function 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate. thyroxine carotid beta stiffness aging carotid strain thyroid hormone heart rate Medicine R Angelo Scuteri verfasserin aut Edoardo Fiorillo verfasserin aut Valeria Orrù verfasserin aut Edward G. Lakatta verfasserin aut David Schlessinger verfasserin aut Francesco Cucca verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 420 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 420 https://doi.org/10.3390/jcm10030420 kostenfrei https://doaj.org/article/af2db2405929477e9fdf1a81d4a3106d kostenfrei https://www.mdpi.com/2077-0383/10/3/420 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 420
allfieldsGer	10.3390/jcm10030420 doi (DE-627)DOAJ059143088 (DE-599)DOAJaf2db2405929477e9fdf1a81d4a3106d DE-627 ger DE-627 rakwb eng Alessandro P. Delitala verfasserin aut Carotid Beta Stiffness Association with Thyroid Function 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate. thyroxine carotid beta stiffness aging carotid strain thyroid hormone heart rate Medicine R Angelo Scuteri verfasserin aut Edoardo Fiorillo verfasserin aut Valeria Orrù verfasserin aut Edward G. Lakatta verfasserin aut David Schlessinger verfasserin aut Francesco Cucca verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 420 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 420 https://doi.org/10.3390/jcm10030420 kostenfrei https://doaj.org/article/af2db2405929477e9fdf1a81d4a3106d kostenfrei https://www.mdpi.com/2077-0383/10/3/420 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 420
allfieldsSound	10.3390/jcm10030420 doi (DE-627)DOAJ059143088 (DE-599)DOAJaf2db2405929477e9fdf1a81d4a3106d DE-627 ger DE-627 rakwb eng Alessandro P. Delitala verfasserin aut Carotid Beta Stiffness Association with Thyroid Function 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate. thyroxine carotid beta stiffness aging carotid strain thyroid hormone heart rate Medicine R Angelo Scuteri verfasserin aut Edoardo Fiorillo verfasserin aut Valeria Orrù verfasserin aut Edward G. Lakatta verfasserin aut David Schlessinger verfasserin aut Francesco Cucca verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 420 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 420 https://doi.org/10.3390/jcm10030420 kostenfrei https://doaj.org/article/af2db2405929477e9fdf1a81d4a3106d kostenfrei https://www.mdpi.com/2077-0383/10/3/420 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 420
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Delitala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Carotid Beta Stiffness Association with Thyroid Function</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. 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author	Alessandro P. Delitala
spellingShingle	Alessandro P. Delitala misc thyroxine misc carotid beta stiffness misc aging misc carotid strain misc thyroid hormone misc heart rate misc Medicine misc R Carotid Beta Stiffness Association with Thyroid Function
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topic_title	Carotid Beta Stiffness Association with Thyroid Function thyroxine carotid beta stiffness aging carotid strain thyroid hormone heart rate
topic	misc thyroxine misc carotid beta stiffness misc aging misc carotid strain misc thyroid hormone misc heart rate misc Medicine misc R
topic_unstemmed	misc thyroxine misc carotid beta stiffness misc aging misc carotid strain misc thyroid hormone misc heart rate misc Medicine misc R
topic_browse	misc thyroxine misc carotid beta stiffness misc aging misc carotid strain misc thyroid hormone misc heart rate misc Medicine misc R
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title	Carotid Beta Stiffness Association with Thyroid Function
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title_full	Carotid Beta Stiffness Association with Thyroid Function
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author_browse	Alessandro P. Delitala Angelo Scuteri Edoardo Fiorillo Valeria Orrù Edward G. Lakatta David Schlessinger Francesco Cucca
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title_sort	carotid beta stiffness association with thyroid function
title_auth	Carotid Beta Stiffness Association with Thyroid Function
abstract	Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate.
abstractGer	Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate.
abstract_unstemmed	Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall–lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate.
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title_short	Carotid Beta Stiffness Association with Thyroid Function
url	https://doi.org/10.3390/jcm10030420 https://doaj.org/article/af2db2405929477e9fdf1a81d4a3106d https://www.mdpi.com/2077-0383/10/3/420 https://doaj.org/toc/2077-0383
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author2	Angelo Scuteri Edoardo Fiorillo Valeria Orrù Edward G. Lakatta David Schlessinger Francesco Cucca
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up_date	2024-07-03T22:00:52.599Z
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Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, <i<p</i< = 0.041), and had a negative association with strain (β = −0.025, <i<p</i< = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, <i<p</i< = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, <i<p</i< < 0.001) as well as their interaction (β = 0.271, <i<p</i< = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. 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