Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs

This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritio...
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Autor*in:	Reshma M. Anthony [verfasserIn] Jennifer M. MacLeay [verfasserIn] Dennis E. Jewell [verfasserIn] John J. Brejda [verfasserIn] Kathy L. Gross [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	alpha-lipoic acid nutritive antioxidant glutathione healthy adult dogs

Übergeordnetes Werk:	In: Animals - MDPI AG, 2011, 11(2021), 2, p 274
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:2, p 274

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ani11020274

Katalog-ID:	DOAJ059143797

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callnumber-first	S - Agriculture
author	Reshma M. Anthony
spellingShingle	Reshma M. Anthony misc SF600-1100 misc QL1-991 misc alpha-lipoic misc acid misc nutritive antioxidant misc glutathione misc healthy adult dogs misc Veterinary medicine misc Zoology Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
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topic_title	SF600-1100 QL1-991 Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs alpha-lipoic acid nutritive antioxidant glutathione healthy adult dogs
topic	misc SF600-1100 misc QL1-991 misc alpha-lipoic misc acid misc nutritive antioxidant misc glutathione misc healthy adult dogs misc Veterinary medicine misc Zoology
topic_unstemmed	misc SF600-1100 misc QL1-991 misc alpha-lipoic misc acid misc nutritive antioxidant misc glutathione misc healthy adult dogs misc Veterinary medicine misc Zoology
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title	Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
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title_full	Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
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author_browse	Reshma M. Anthony Jennifer M. MacLeay Dennis E. Jewell John J. Brejda Kathy L. Gross
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title_sort	alpha-lipoic acid is an effective nutritive antioxidant for healthy adult dogs
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title_auth	Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
abstract	This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6. We conclude that alpha-lipoic acid, as part of a complete and balanced food, was associated with increasing glutathione activity in healthy adult dogs.
abstractGer	This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6. We conclude that alpha-lipoic acid, as part of a complete and balanced food, was associated with increasing glutathione activity in healthy adult dogs.
abstract_unstemmed	This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6. We conclude that alpha-lipoic acid, as part of a complete and balanced food, was associated with increasing glutathione activity in healthy adult dogs.
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title_short	Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
url	https://doi.org/10.3390/ani11020274 https://doaj.org/article/0e19eaed944a4ba79a8b031da5c5c7ac https://www.mdpi.com/2076-2615/11/2/274 https://doaj.org/toc/2076-2615
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up_date	2024-07-03T22:01:08.123Z
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Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6. 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Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs

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