Clinical features of

Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	M. Sh. Badawy [verfasserIn] A.F. El Qarn [verfasserIn] H.A. Mohamadeen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	COPD Clinical features Alpha1 antitrypsin deficiency

Übergeordnetes Werk:	In: Egyptian Journal of Chest Disease and Tuberculosis - Wolters Kluwer Medknow Publications, 2016, 62(2013), 1, Seite 71-77
Übergeordnetes Werk:	volume:62 ; year:2013 ; number:1 ; pages:71-77

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ejcdt.2013.05.007

Katalog-ID:	DOAJ059328568

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520			\|a Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD.
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spelling	10.1016/j.ejcdt.2013.05.007 doi (DE-627)DOAJ059328568 (DE-599)DOAJb0b9584869dc4db0a1a2c6e5b574d0ab DE-627 ger DE-627 rakwb eng RC705-779 M. Sh. Badawy verfasserin aut Clinical features of 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD. COPD Clinical features Alpha1 antitrypsin deficiency Diseases of the respiratory system A.F. El Qarn verfasserin aut H.A. Mohamadeen verfasserin aut In Egyptian Journal of Chest Disease and Tuberculosis Wolters Kluwer Medknow Publications, 2016 62(2013), 1, Seite 71-77 (DE-627)820688878 (DE-600)2814778-9 20909950 nnns volume:62 year:2013 number:1 pages:71-77 https://doi.org/10.1016/j.ejcdt.2013.05.007 kostenfrei https://doaj.org/article/b0b9584869dc4db0a1a2c6e5b574d0ab kostenfrei http://www.sciencedirect.com/science/article/pii/S0422763813001015 kostenfrei https://doaj.org/toc/0422-7638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2013 1 71-77
allfields_unstemmed	10.1016/j.ejcdt.2013.05.007 doi (DE-627)DOAJ059328568 (DE-599)DOAJb0b9584869dc4db0a1a2c6e5b574d0ab DE-627 ger DE-627 rakwb eng RC705-779 M. Sh. Badawy verfasserin aut Clinical features of 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD. COPD Clinical features Alpha1 antitrypsin deficiency Diseases of the respiratory system A.F. El Qarn verfasserin aut H.A. Mohamadeen verfasserin aut In Egyptian Journal of Chest Disease and Tuberculosis Wolters Kluwer Medknow Publications, 2016 62(2013), 1, Seite 71-77 (DE-627)820688878 (DE-600)2814778-9 20909950 nnns volume:62 year:2013 number:1 pages:71-77 https://doi.org/10.1016/j.ejcdt.2013.05.007 kostenfrei https://doaj.org/article/b0b9584869dc4db0a1a2c6e5b574d0ab kostenfrei http://www.sciencedirect.com/science/article/pii/S0422763813001015 kostenfrei https://doaj.org/toc/0422-7638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2013 1 71-77
allfieldsGer	10.1016/j.ejcdt.2013.05.007 doi (DE-627)DOAJ059328568 (DE-599)DOAJb0b9584869dc4db0a1a2c6e5b574d0ab DE-627 ger DE-627 rakwb eng RC705-779 M. Sh. Badawy verfasserin aut Clinical features of 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD. COPD Clinical features Alpha1 antitrypsin deficiency Diseases of the respiratory system A.F. El Qarn verfasserin aut H.A. Mohamadeen verfasserin aut In Egyptian Journal of Chest Disease and Tuberculosis Wolters Kluwer Medknow Publications, 2016 62(2013), 1, Seite 71-77 (DE-627)820688878 (DE-600)2814778-9 20909950 nnns volume:62 year:2013 number:1 pages:71-77 https://doi.org/10.1016/j.ejcdt.2013.05.007 kostenfrei https://doaj.org/article/b0b9584869dc4db0a1a2c6e5b574d0ab kostenfrei http://www.sciencedirect.com/science/article/pii/S0422763813001015 kostenfrei https://doaj.org/toc/0422-7638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2013 1 71-77
allfieldsSound	10.1016/j.ejcdt.2013.05.007 doi (DE-627)DOAJ059328568 (DE-599)DOAJb0b9584869dc4db0a1a2c6e5b574d0ab DE-627 ger DE-627 rakwb eng RC705-779 M. Sh. Badawy verfasserin aut Clinical features of 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD. COPD Clinical features Alpha1 antitrypsin deficiency Diseases of the respiratory system A.F. El Qarn verfasserin aut H.A. Mohamadeen verfasserin aut In Egyptian Journal of Chest Disease and Tuberculosis Wolters Kluwer Medknow Publications, 2016 62(2013), 1, Seite 71-77 (DE-627)820688878 (DE-600)2814778-9 20909950 nnns volume:62 year:2013 number:1 pages:71-77 https://doi.org/10.1016/j.ejcdt.2013.05.007 kostenfrei https://doaj.org/article/b0b9584869dc4db0a1a2c6e5b574d0ab kostenfrei http://www.sciencedirect.com/science/article/pii/S0422763813001015 kostenfrei https://doaj.org/toc/0422-7638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2013 1 71-77
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Sh. Badawy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Clinical features of</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). 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There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. 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callnumber-first	R - Medicine
author	M. Sh. Badawy
spellingShingle	M. Sh. Badawy misc RC705-779 misc COPD misc Clinical features misc Alpha1 antitrypsin deficiency misc Diseases of the respiratory system Clinical features of
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topic_title	RC705-779 Clinical features of COPD Clinical features Alpha1 antitrypsin deficiency
topic	misc RC705-779 misc COPD misc Clinical features misc Alpha1 antitrypsin deficiency misc Diseases of the respiratory system
topic_unstemmed	misc RC705-779 misc COPD misc Clinical features misc Alpha1 antitrypsin deficiency misc Diseases of the respiratory system
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title	Clinical features of
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author_browse	M. Sh. Badawy A.F. El Qarn H.A. Mohamadeen
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title_sort	clinical features of
callnumber	RC705-779
title_auth	Clinical features of
abstract	Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD.
abstractGer	Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD.
abstract_unstemmed	Setting: About 1–3% of patients with diagnosed chronic obstructive pulmonary disease (COPD) is predicted to have alpha1-antitrypsin deficiency (A1ATD). Objective: To clinically evaluate and increase recognition of AATD in patients with COPD. Materials and methods: Sixty COPD patients were diagnosed on the basis of clinical and pulmonary function tests. They fulfilled the inclusion criteria and divided into group (A) COPD above 40 years (30 cases) and group (B) COPD below 40 years (30 cases). All patients were subjected thorough history taking, radiological examination, blood gas analysis and quantitative measurements of serum alpha-1 antitrypsin by radio-immunoassay. Results: Mean ages of the groups A and B were (61.87 ± 6.04, 34.17 ± 2.75) respectively with (p value <0.001). The mean serum levels of alpha 1 antitrypsin in groups A and B were (185.03 ± 23.00 with only one case deficient and 177.53 ± 49.94 with only four cases deficient) respectively without statistical significance. There is significant relationship between the age of the patient and A1ATD, where in deficient patients mean age was 39.63 ± 13.66, and in normal patients mean age was 50.18 ± 12.06) with (p value 0.02). There is also significant relationship between family history and A1ATD, where in deficient patients 50% of cases (four cases) had positive family history, in contrast to 11.61% of cases (13 cases) of normal patients (p value 0.03). There is no significant difference between the deficient and normal group as regards gender distribution, smoking history, symptomatic presentations, physical signs, radiological picture, pulmonary function tests and blood gas parameters. Conclusion: Emphysema at an early age, non smokers with positive family history is a clinical feature suggestive of A1ATD.
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title_short	Clinical features of
url	https://doi.org/10.1016/j.ejcdt.2013.05.007 https://doaj.org/article/b0b9584869dc4db0a1a2c6e5b574d0ab http://www.sciencedirect.com/science/article/pii/S0422763813001015 https://doaj.org/toc/0422-7638
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up_date	2024-07-03T22:57:00.422Z
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