Metabolic origins and clinical significance of LDL heterogeneity

LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL precursors, metabolic remodeling, and direct pr...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kaspar K. Berneis [verfasserIn] Ronald M. Krauss [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	atherosclerosis low density lipoprotein lipoprotein subclasses insulin resistance intermediate density lipoprotein very low density lipoprotein

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 43(2002), 9, Seite 1363-1379
Übergeordnetes Werk:	volume:43 ; year:2002 ; number:9 ; pages:1363-1379

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.R200004-JLR200

Katalog-ID:	DOAJ059433566

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520			\|a LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL precursors, metabolic remodeling, and direct production. A common lipoprotein profile designated atherogenic lipoprotein phenotype is characterized by a predominance of small dense LDL particles. Multiple features of this phenotype, including increased levels of triglyceride rich lipoprotein remnants and IDLs, reduced levels of HDL and an association with insulin resistance, contribute to increased risk for coronary heart disease compared with individuals with a predominance of larger LDL. Increased atherogenic potential of small dense LDL is suggested by greater propensity for transport into the subendothelial space, increased binding to arterial proteoglycans, and susceptibility to oxidative modification. Large LDL particles also can be associated with increased coronary disease risk, particularly in the setting of normal or low triglyceride levels. Like small LDL, large LDL exhibits reduced LDL receptor affinity compared with intermediate sized LDL.Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease.
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language	English
source	In Journal of Lipid Research 43(2002), 9, Seite 1363-1379 volume:43 year:2002 number:9 pages:1363-1379
sourceStr	In Journal of Lipid Research 43(2002), 9, Seite 1363-1379 volume:43 year:2002 number:9 pages:1363-1379
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	atherosclerosis low density lipoprotein lipoprotein subclasses insulin resistance intermediate density lipoprotein very low density lipoprotein Biochemistry
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container_title	Journal of Lipid Research
authorswithroles_txt_mv	Kaspar K. Berneis @@aut@@ Ronald M. Krauss @@aut@@
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spellingShingle	Kaspar K. Berneis misc QD415-436 misc atherosclerosis misc low density lipoprotein misc lipoprotein subclasses misc insulin resistance misc intermediate density lipoprotein misc very low density lipoprotein misc Biochemistry Metabolic origins and clinical significance of LDL heterogeneity
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topic_title	QD415-436 Metabolic origins and clinical significance of LDL heterogeneity atherosclerosis low density lipoprotein lipoprotein subclasses insulin resistance intermediate density lipoprotein very low density lipoprotein
topic	misc QD415-436 misc atherosclerosis misc low density lipoprotein misc lipoprotein subclasses misc insulin resistance misc intermediate density lipoprotein misc very low density lipoprotein misc Biochemistry
topic_unstemmed	misc QD415-436 misc atherosclerosis misc low density lipoprotein misc lipoprotein subclasses misc insulin resistance misc intermediate density lipoprotein misc very low density lipoprotein misc Biochemistry
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title	Metabolic origins and clinical significance of LDL heterogeneity
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title_full	Metabolic origins and clinical significance of LDL heterogeneity
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title_sort	metabolic origins and clinical significance of ldl heterogeneity
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title_auth	Metabolic origins and clinical significance of LDL heterogeneity
abstract	LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL precursors, metabolic remodeling, and direct production. A common lipoprotein profile designated atherogenic lipoprotein phenotype is characterized by a predominance of small dense LDL particles. Multiple features of this phenotype, including increased levels of triglyceride rich lipoprotein remnants and IDLs, reduced levels of HDL and an association with insulin resistance, contribute to increased risk for coronary heart disease compared with individuals with a predominance of larger LDL. Increased atherogenic potential of small dense LDL is suggested by greater propensity for transport into the subendothelial space, increased binding to arterial proteoglycans, and susceptibility to oxidative modification. Large LDL particles also can be associated with increased coronary disease risk, particularly in the setting of normal or low triglyceride levels. Like small LDL, large LDL exhibits reduced LDL receptor affinity compared with intermediate sized LDL.Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease.
abstractGer	LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL precursors, metabolic remodeling, and direct production. A common lipoprotein profile designated atherogenic lipoprotein phenotype is characterized by a predominance of small dense LDL particles. Multiple features of this phenotype, including increased levels of triglyceride rich lipoprotein remnants and IDLs, reduced levels of HDL and an association with insulin resistance, contribute to increased risk for coronary heart disease compared with individuals with a predominance of larger LDL. Increased atherogenic potential of small dense LDL is suggested by greater propensity for transport into the subendothelial space, increased binding to arterial proteoglycans, and susceptibility to oxidative modification. Large LDL particles also can be associated with increased coronary disease risk, particularly in the setting of normal or low triglyceride levels. Like small LDL, large LDL exhibits reduced LDL receptor affinity compared with intermediate sized LDL.Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease.
abstract_unstemmed	LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL precursors, metabolic remodeling, and direct production. A common lipoprotein profile designated atherogenic lipoprotein phenotype is characterized by a predominance of small dense LDL particles. Multiple features of this phenotype, including increased levels of triglyceride rich lipoprotein remnants and IDLs, reduced levels of HDL and an association with insulin resistance, contribute to increased risk for coronary heart disease compared with individuals with a predominance of larger LDL. Increased atherogenic potential of small dense LDL is suggested by greater propensity for transport into the subendothelial space, increased binding to arterial proteoglycans, and susceptibility to oxidative modification. Large LDL particles also can be associated with increased coronary disease risk, particularly in the setting of normal or low triglyceride levels. Like small LDL, large LDL exhibits reduced LDL receptor affinity compared with intermediate sized LDL.Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease.
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title_short	Metabolic origins and clinical significance of LDL heterogeneity
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Metabolic origins and clinical significance of LDL heterogeneity

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