Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study

Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer mon...
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Autor*in:	Marianna Noale [verfasserIn] Alessio Bruni [verfasserIn] Luca Triggiani [verfasserIn] Michela Buglione [verfasserIn] Filippo Bertoni [verfasserIn] Luca Frassinelli [verfasserIn] Rodolfo Montironi [verfasserIn] Renzo Corvò [verfasserIn] Vittorina Zagonel [verfasserIn] Angelo Porreca [verfasserIn] Pierfrancesco Bassi [verfasserIn] Mauro Gacci [verfasserIn] Giario Natale Conti [verfasserIn] Stefania Maggi [verfasserIn] Stefano Magrini [verfasserIn] The Pros-IT CNR Study Group [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	prostate cancer health-related quality of life growth mixture model radiation therapy

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 6, p 1479
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:6, p 1479

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13061479

Katalog-ID:	DOAJ059450096

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allfields	10.3390/cancers13061479 doi (DE-627)DOAJ059450096 (DE-599)DOAJ875fcf8a439e4b22a28e39db801e9fef DE-627 ger DE-627 rakwb eng RC254-282 Marianna Noale verfasserin aut Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects. prostate cancer health-related quality of life growth mixture model radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessio Bruni verfasserin aut Luca Triggiani verfasserin aut Michela Buglione verfasserin aut Filippo Bertoni verfasserin aut Luca Frassinelli verfasserin aut Rodolfo Montironi verfasserin aut Renzo Corvò verfasserin aut Vittorina Zagonel verfasserin aut Angelo Porreca verfasserin aut Pierfrancesco Bassi verfasserin aut Mauro Gacci verfasserin aut Giario Natale Conti verfasserin aut Stefania Maggi verfasserin aut Stefano Magrini verfasserin aut The Pros-IT CNR Study Group verfasserin aut In Cancers MDPI AG, 2010 13(2021), 6, p 1479 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:6, p 1479 https://doi.org/10.3390/cancers13061479 kostenfrei https://doaj.org/article/875fcf8a439e4b22a28e39db801e9fef kostenfrei https://www.mdpi.com/2072-6694/13/6/1479 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6, p 1479
spelling	10.3390/cancers13061479 doi (DE-627)DOAJ059450096 (DE-599)DOAJ875fcf8a439e4b22a28e39db801e9fef DE-627 ger DE-627 rakwb eng RC254-282 Marianna Noale verfasserin aut Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects. prostate cancer health-related quality of life growth mixture model radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessio Bruni verfasserin aut Luca Triggiani verfasserin aut Michela Buglione verfasserin aut Filippo Bertoni verfasserin aut Luca Frassinelli verfasserin aut Rodolfo Montironi verfasserin aut Renzo Corvò verfasserin aut Vittorina Zagonel verfasserin aut Angelo Porreca verfasserin aut Pierfrancesco Bassi verfasserin aut Mauro Gacci verfasserin aut Giario Natale Conti verfasserin aut Stefania Maggi verfasserin aut Stefano Magrini verfasserin aut The Pros-IT CNR Study Group verfasserin aut In Cancers MDPI AG, 2010 13(2021), 6, p 1479 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:6, p 1479 https://doi.org/10.3390/cancers13061479 kostenfrei https://doaj.org/article/875fcf8a439e4b22a28e39db801e9fef kostenfrei https://www.mdpi.com/2072-6694/13/6/1479 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6, p 1479
allfields_unstemmed	10.3390/cancers13061479 doi (DE-627)DOAJ059450096 (DE-599)DOAJ875fcf8a439e4b22a28e39db801e9fef DE-627 ger DE-627 rakwb eng RC254-282 Marianna Noale verfasserin aut Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects. prostate cancer health-related quality of life growth mixture model radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessio Bruni verfasserin aut Luca Triggiani verfasserin aut Michela Buglione verfasserin aut Filippo Bertoni verfasserin aut Luca Frassinelli verfasserin aut Rodolfo Montironi verfasserin aut Renzo Corvò verfasserin aut Vittorina Zagonel verfasserin aut Angelo Porreca verfasserin aut Pierfrancesco Bassi verfasserin aut Mauro Gacci verfasserin aut Giario Natale Conti verfasserin aut Stefania Maggi verfasserin aut Stefano Magrini verfasserin aut The Pros-IT CNR Study Group verfasserin aut In Cancers MDPI AG, 2010 13(2021), 6, p 1479 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:6, p 1479 https://doi.org/10.3390/cancers13061479 kostenfrei https://doaj.org/article/875fcf8a439e4b22a28e39db801e9fef kostenfrei https://www.mdpi.com/2072-6694/13/6/1479 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6, p 1479
allfieldsGer	10.3390/cancers13061479 doi (DE-627)DOAJ059450096 (DE-599)DOAJ875fcf8a439e4b22a28e39db801e9fef DE-627 ger DE-627 rakwb eng RC254-282 Marianna Noale verfasserin aut Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects. prostate cancer health-related quality of life growth mixture model radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessio Bruni verfasserin aut Luca Triggiani verfasserin aut Michela Buglione verfasserin aut Filippo Bertoni verfasserin aut Luca Frassinelli verfasserin aut Rodolfo Montironi verfasserin aut Renzo Corvò verfasserin aut Vittorina Zagonel verfasserin aut Angelo Porreca verfasserin aut Pierfrancesco Bassi verfasserin aut Mauro Gacci verfasserin aut Giario Natale Conti verfasserin aut Stefania Maggi verfasserin aut Stefano Magrini verfasserin aut The Pros-IT CNR Study Group verfasserin aut In Cancers MDPI AG, 2010 13(2021), 6, p 1479 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:6, p 1479 https://doi.org/10.3390/cancers13061479 kostenfrei https://doaj.org/article/875fcf8a439e4b22a28e39db801e9fef kostenfrei https://www.mdpi.com/2072-6694/13/6/1479 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6, p 1479
allfieldsSound	10.3390/cancers13061479 doi (DE-627)DOAJ059450096 (DE-599)DOAJ875fcf8a439e4b22a28e39db801e9fef DE-627 ger DE-627 rakwb eng RC254-282 Marianna Noale verfasserin aut Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects. prostate cancer health-related quality of life growth mixture model radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alessio Bruni verfasserin aut Luca Triggiani verfasserin aut Michela Buglione verfasserin aut Filippo Bertoni verfasserin aut Luca Frassinelli verfasserin aut Rodolfo Montironi verfasserin aut Renzo Corvò verfasserin aut Vittorina Zagonel verfasserin aut Angelo Porreca verfasserin aut Pierfrancesco Bassi verfasserin aut Mauro Gacci verfasserin aut Giario Natale Conti verfasserin aut Stefania Maggi verfasserin aut Stefano Magrini verfasserin aut The Pros-IT CNR Study Group verfasserin aut In Cancers MDPI AG, 2010 13(2021), 6, p 1479 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:6, p 1479 https://doi.org/10.3390/cancers13061479 kostenfrei https://doaj.org/article/875fcf8a439e4b22a28e39db801e9fef kostenfrei https://www.mdpi.com/2072-6694/13/6/1479 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6, p 1479
language	English
source	In Cancers 13(2021), 6, p 1479 volume:13 year:2021 number:6, p 1479
sourceStr	In Cancers 13(2021), 6, p 1479 volume:13 year:2021 number:6, p 1479
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	prostate cancer health-related quality of life growth mixture model radiation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Marianna Noale @@aut@@ Alessio Bruni @@aut@@ Luca Triggiani @@aut@@ Michela Buglione @@aut@@ Filippo Bertoni @@aut@@ Luca Frassinelli @@aut@@ Rodolfo Montironi @@aut@@ Renzo Corvò @@aut@@ Vittorina Zagonel @@aut@@ Angelo Porreca @@aut@@ Pierfrancesco Bassi @@aut@@ Mauro Gacci @@aut@@ Giario Natale Conti @@aut@@ Stefania Maggi @@aut@@ Stefano Magrini @@aut@@ The Pros-IT CNR Study Group @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	614095670
id	DOAJ059450096
language_de	englisch
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callnumber-first	R - Medicine
author	Marianna Noale
spellingShingle	Marianna Noale misc RC254-282 misc prostate cancer misc health-related quality of life misc growth mixture model misc radiation therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study
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topic_title	RC254-282 Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study prostate cancer health-related quality of life growth mixture model radiation therapy
topic	misc RC254-282 misc prostate cancer misc health-related quality of life misc growth mixture model misc radiation therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc prostate cancer misc health-related quality of life misc growth mixture model misc radiation therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc prostate cancer misc health-related quality of life misc growth mixture model misc radiation therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study
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title_full	Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study
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author_browse	Marianna Noale Alessio Bruni Luca Triggiani Michela Buglione Filippo Bertoni Luca Frassinelli Rodolfo Montironi Renzo Corvò Vittorina Zagonel Angelo Porreca Pierfrancesco Bassi Mauro Gacci Giario Natale Conti Stefania Maggi Stefano Magrini The Pros-IT CNR Study Group
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author-letter	Marianna Noale
doi_str_mv	10.3390/cancers13061479
author2-role	verfasserin
title_sort	impact of gastrointestinal side effects on patients’ reported quality of life trajectories after radiotherapy for prostate cancer: data from the prospective, observational pros-it cnr study
callnumber	RC254-282
title_auth	Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study
abstract	Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects.
abstractGer	Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects.
abstract_unstemmed	Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects.
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container_issue	6, p 1479
title_short	Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study
url	https://doi.org/10.3390/cancers13061479 https://doaj.org/article/875fcf8a439e4b22a28e39db801e9fef https://www.mdpi.com/2072-6694/13/6/1479 https://doaj.org/toc/2072-6694
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author2	Alessio Bruni Luca Triggiani Michela Buglione Filippo Bertoni Luca Frassinelli Rodolfo Montironi Renzo Corvò Vittorina Zagonel Angelo Porreca Pierfrancesco Bassi Mauro Gacci Giario Natale Conti Stefania Maggi Stefano Magrini The Pros-IT CNR Study Group
author2Str	Alessio Bruni Luca Triggiani Michela Buglione Filippo Bertoni Luca Frassinelli Rodolfo Montironi Renzo Corvò Vittorina Zagonel Angelo Porreca Pierfrancesco Bassi Mauro Gacci Giario Natale Conti Stefania Maggi Stefano Magrini The Pros-IT CNR Study Group
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Impact of Gastrointestinal Side Effects on Patients’ Reported Quality of Life Trajectories after Radiotherapy for Prostate Cancer: Data from the Prospective, Observational Pros-IT CNR Study

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