Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men

The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the im...
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Gespeichert in:

Autor*in:	Marie-Thérèse Berthier [verfasserIn] Alain Houde [verfasserIn] Mélanie Côté [verfasserIn] Ann-Marie Paradis [verfasserIn] Pascale Mauriège [verfasserIn] Jean Bergeron [verfasserIn] Daniel Gaudet [verfasserIn] Jean-Pierre Després [verfasserIn] Marie-Claude Vohl [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	Apm1 dyslipidemia insulin resistance

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 46(2005), 2, Seite 237-244
Übergeordnetes Werk:	volume:46 ; year:2005 ; number:2 ; pages:237-244

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M400135-JLR200

Katalog-ID:	DOAJ059452641

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allfields	10.1194/jlr.M400135-JLR200 doi (DE-627)DOAJ059452641 (DE-599)DOAJ5b4eeecb8c8e4d8ba00fad34fdc3cfee DE-627 ger DE-627 rakwb eng QD415-436 Marie-Thérèse Berthier verfasserin aut Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T<G and c.276G<T) as well as two newly identified genetic variations (−13752delT and −13702G<C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity. Apm1 dyslipidemia insulin resistance Biochemistry Alain Houde verfasserin aut Mélanie Côté verfasserin aut Ann-Marie Paradis verfasserin aut Pascale Mauriège verfasserin aut Jean Bergeron verfasserin aut Daniel Gaudet verfasserin aut Jean-Pierre Després verfasserin aut Marie-Claude Vohl verfasserin aut In Journal of Lipid Research Elsevier, 2021 46(2005), 2, Seite 237-244 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:46 year:2005 number:2 pages:237-244 https://doi.org/10.1194/jlr.M400135-JLR200 kostenfrei https://doaj.org/article/5b4eeecb8c8e4d8ba00fad34fdc3cfee kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520340566 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2005 2 237-244
spelling	10.1194/jlr.M400135-JLR200 doi (DE-627)DOAJ059452641 (DE-599)DOAJ5b4eeecb8c8e4d8ba00fad34fdc3cfee DE-627 ger DE-627 rakwb eng QD415-436 Marie-Thérèse Berthier verfasserin aut Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T<G and c.276G<T) as well as two newly identified genetic variations (−13752delT and −13702G<C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity. Apm1 dyslipidemia insulin resistance Biochemistry Alain Houde verfasserin aut Mélanie Côté verfasserin aut Ann-Marie Paradis verfasserin aut Pascale Mauriège verfasserin aut Jean Bergeron verfasserin aut Daniel Gaudet verfasserin aut Jean-Pierre Després verfasserin aut Marie-Claude Vohl verfasserin aut In Journal of Lipid Research Elsevier, 2021 46(2005), 2, Seite 237-244 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:46 year:2005 number:2 pages:237-244 https://doi.org/10.1194/jlr.M400135-JLR200 kostenfrei https://doaj.org/article/5b4eeecb8c8e4d8ba00fad34fdc3cfee kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520340566 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2005 2 237-244
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allfieldsSound	10.1194/jlr.M400135-JLR200 doi (DE-627)DOAJ059452641 (DE-599)DOAJ5b4eeecb8c8e4d8ba00fad34fdc3cfee DE-627 ger DE-627 rakwb eng QD415-436 Marie-Thérèse Berthier verfasserin aut Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T<G and c.276G<T) as well as two newly identified genetic variations (−13752delT and −13702G<C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity. Apm1 dyslipidemia insulin resistance Biochemistry Alain Houde verfasserin aut Mélanie Côté verfasserin aut Ann-Marie Paradis verfasserin aut Pascale Mauriège verfasserin aut Jean Bergeron verfasserin aut Daniel Gaudet verfasserin aut Jean-Pierre Després verfasserin aut Marie-Claude Vohl verfasserin aut In Journal of Lipid Research Elsevier, 2021 46(2005), 2, Seite 237-244 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:46 year:2005 number:2 pages:237-244 https://doi.org/10.1194/jlr.M400135-JLR200 kostenfrei https://doaj.org/article/5b4eeecb8c8e4d8ba00fad34fdc3cfee kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520340566 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2005 2 237-244
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author	Marie-Thérèse Berthier
spellingShingle	Marie-Thérèse Berthier misc QD415-436 misc Apm1 misc dyslipidemia misc insulin resistance misc Biochemistry Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
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topic_title	QD415-436 Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men Apm1 dyslipidemia insulin resistance
topic	misc QD415-436 misc Apm1 misc dyslipidemia misc insulin resistance misc Biochemistry
topic_unstemmed	misc QD415-436 misc Apm1 misc dyslipidemia misc insulin resistance misc Biochemistry
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title	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
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title_full	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
author_sort	Marie-Thérèse Berthier
journal	Journal of Lipid Research
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author_browse	Marie-Thérèse Berthier Alain Houde Mélanie Côté Ann-Marie Paradis Pascale Mauriège Jean Bergeron Daniel Gaudet Jean-Pierre Després Marie-Claude Vohl
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title_sort	impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
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title_auth	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
abstract	The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T<G and c.276G<T) as well as two newly identified genetic variations (−13752delT and −13702G<C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity.
abstractGer	The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T<G and c.276G<T) as well as two newly identified genetic variations (−13752delT and −13702G<C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity.
abstract_unstemmed	The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polymorphisms on metabolic risk variables. Molecular screening of the Apm1 gene was achieved, and a sample of 270 unrelated men recruited from the greater Quebec City area and selected to cover a wide range of body fatness values was genotyped. Sequencing of the Apm1 gene revealed two previously reported polymorphisms (c.45T<G and c.276G<T) as well as two newly identified genetic variations (−13752delT and −13702G<C). Carriers of the c.276T allele had higher LDL-cholesterol and lower HDL-triglyceride concentrations than did 276G/G homozygotes (P = 0.02 and P = 0.01, respectively). Carriers of the c.45G allele exhibited higher plasma adiponectin concentrations than did 45T/T homozygotes (P = 0.04). After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity.
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title_short	Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
url	https://doi.org/10.1194/jlr.M400135-JLR200 https://doaj.org/article/5b4eeecb8c8e4d8ba00fad34fdc3cfee http://www.sciencedirect.com/science/article/pii/S0022227520340566 https://doaj.org/toc/0022-2275
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up_date	2024-07-03T23:32:42.152Z
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After dividing each genotype group into subgroups for visceral AT, homozygotes for the normal allele at position −13752delT, carriers of the c.45G allele, and carriers of the c.276T allele had similar total apolipoprotein B (apoB) concentrations, whether they were viscerally obese or not.These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. 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Research</subfield><subfield code="d">Elsevier, 2021</subfield><subfield code="g">46(2005), 2, Seite 237-244</subfield><subfield code="w">(DE-627)26601593X</subfield><subfield code="w">(DE-600)1466675-3</subfield><subfield code="x">15397262</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:46</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:237-244</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1194/jlr.M400135-JLR200</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/5b4eeecb8c8e4d8ba00fad34fdc3cfee</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S0022227520340566</subfield><subfield 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Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men

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