Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from...
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Gespeichert in:

Autor*in:	Marika Rossini [verfasserIn] Fernanda Martini [verfasserIn] Elena Torreggiani [verfasserIn] Francesca Fortini [verfasserIn] Giorgio Aquila [verfasserIn] Francesco Vieceli Dalla Sega [verfasserIn] Simone Patergnani [verfasserIn] Paolo Pinton [verfasserIn] Pio Maniscalco [verfasserIn] Giorgio Cavallesco [verfasserIn] Paola Rizzo [verfasserIn] Mauro Tognon [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	malignant pleural mesothelioma metformin cell proliferation apoptosis NOTCH1

Übergeordnetes Werk:	In: Frontiers in Cell and Developmental Biology - Frontiers Media S.A., 2014, 8(2021)
Übergeordnetes Werk:	volume:8 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcell.2020.534499

Katalog-ID:	DOAJ059461543

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spelling	10.3389/fcell.2020.534499 doi (DE-627)DOAJ059461543 (DE-599)DOAJ3809a2cd02954e269f9aaf77ea51cf48 DE-627 ger DE-627 rakwb eng QH301-705.5 Marika Rossini verfasserin aut Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from diagnosis. Notch signaling is a well-conserved cell communication system, which regulates many biological processes. In humans, the dysregulation of Notch pathway potentially contributes to cancer onset/progression, including MPM. Metformin is the first-line drug used to treat type 2 diabetes mellitus. Metformin is proven to be an effective antitumor drug in preclinical models of different types of cancer. To date, clinical efficacy is being studied in many clinical trials. In this study, the anti-proliferative effect of metformin on MPM cells and the putative involvement of Notch1 as a mediator of metformin activities, were investigated. MPM cells showed high levels of Notch1 activation compared to normal pleural mesothelial cells. Furthermore, metformin treatment hampered MPM cell proliferation and enhanced the apoptotic process, accompanied by decreased Notch1 activation. malignant pleural mesothelioma metformin cell proliferation apoptosis NOTCH1 Biology (General) Fernanda Martini verfasserin aut Fernanda Martini verfasserin aut Elena Torreggiani verfasserin aut Francesca Fortini verfasserin aut Giorgio Aquila verfasserin aut Francesco Vieceli Dalla Sega verfasserin aut Simone Patergnani verfasserin aut Simone Patergnani verfasserin aut Paolo Pinton verfasserin aut Paolo Pinton verfasserin aut Pio Maniscalco verfasserin aut Giorgio Cavallesco verfasserin aut Paola Rizzo verfasserin aut Paola Rizzo verfasserin aut Mauro Tognon verfasserin aut In Frontiers in Cell and Developmental Biology Frontiers Media S.A., 2014 8(2021) (DE-627)770398138 (DE-600)2737824-X 2296634X nnns volume:8 year:2021 https://doi.org/10.3389/fcell.2020.534499 kostenfrei https://doaj.org/article/3809a2cd02954e269f9aaf77ea51cf48 kostenfrei https://www.frontiersin.org/articles/10.3389/fcell.2020.534499/full kostenfrei https://doaj.org/toc/2296-634X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
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callnumber-first	Q - Science
author	Marika Rossini
spellingShingle	Marika Rossini misc QH301-705.5 misc malignant pleural mesothelioma misc metformin misc cell proliferation misc apoptosis misc NOTCH1 misc Biology (General) Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
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topic_title	QH301-705.5 Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells malignant pleural mesothelioma metformin cell proliferation apoptosis NOTCH1
topic	misc QH301-705.5 misc malignant pleural mesothelioma misc metformin misc cell proliferation misc apoptosis misc NOTCH1 misc Biology (General)
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title	Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
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title_full	Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
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author_browse	Marika Rossini Fernanda Martini Elena Torreggiani Francesca Fortini Giorgio Aquila Francesco Vieceli Dalla Sega Simone Patergnani Paolo Pinton Pio Maniscalco Giorgio Cavallesco Paola Rizzo Mauro Tognon
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title_sort	metformin induces apoptosis and inhibits notch1 in malignant pleural mesothelioma cells
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title_auth	Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
abstract	Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from diagnosis. Notch signaling is a well-conserved cell communication system, which regulates many biological processes. In humans, the dysregulation of Notch pathway potentially contributes to cancer onset/progression, including MPM. Metformin is the first-line drug used to treat type 2 diabetes mellitus. Metformin is proven to be an effective antitumor drug in preclinical models of different types of cancer. To date, clinical efficacy is being studied in many clinical trials. In this study, the anti-proliferative effect of metformin on MPM cells and the putative involvement of Notch1 as a mediator of metformin activities, were investigated. MPM cells showed high levels of Notch1 activation compared to normal pleural mesothelial cells. Furthermore, metformin treatment hampered MPM cell proliferation and enhanced the apoptotic process, accompanied by decreased Notch1 activation.
abstractGer	Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from diagnosis. Notch signaling is a well-conserved cell communication system, which regulates many biological processes. In humans, the dysregulation of Notch pathway potentially contributes to cancer onset/progression, including MPM. Metformin is the first-line drug used to treat type 2 diabetes mellitus. Metformin is proven to be an effective antitumor drug in preclinical models of different types of cancer. To date, clinical efficacy is being studied in many clinical trials. In this study, the anti-proliferative effect of metformin on MPM cells and the putative involvement of Notch1 as a mediator of metformin activities, were investigated. MPM cells showed high levels of Notch1 activation compared to normal pleural mesothelial cells. Furthermore, metformin treatment hampered MPM cell proliferation and enhanced the apoptotic process, accompanied by decreased Notch1 activation.
abstract_unstemmed	Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from diagnosis. Notch signaling is a well-conserved cell communication system, which regulates many biological processes. In humans, the dysregulation of Notch pathway potentially contributes to cancer onset/progression, including MPM. Metformin is the first-line drug used to treat type 2 diabetes mellitus. Metformin is proven to be an effective antitumor drug in preclinical models of different types of cancer. To date, clinical efficacy is being studied in many clinical trials. In this study, the anti-proliferative effect of metformin on MPM cells and the putative involvement of Notch1 as a mediator of metformin activities, were investigated. MPM cells showed high levels of Notch1 activation compared to normal pleural mesothelial cells. Furthermore, metformin treatment hampered MPM cell proliferation and enhanced the apoptotic process, accompanied by decreased Notch1 activation.
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title_short	Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
url	https://doi.org/10.3389/fcell.2020.534499 https://doaj.org/article/3809a2cd02954e269f9aaf77ea51cf48 https://www.frontiersin.org/articles/10.3389/fcell.2020.534499/full https://doaj.org/toc/2296-634X
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up_date	2024-07-03T23:35:06.976Z
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MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from diagnosis. Notch signaling is a well-conserved cell communication system, which regulates many biological processes. In humans, the dysregulation of Notch pathway potentially contributes to cancer onset/progression, including MPM. Metformin is the first-line drug used to treat type 2 diabetes mellitus. Metformin is proven to be an effective antitumor drug in preclinical models of different types of cancer. To date, clinical efficacy is being studied in many clinical trials. In this study, the anti-proliferative effect of metformin on MPM cells and the putative involvement of Notch1 as a mediator of metformin activities, were investigated. MPM cells showed high levels of Notch1 activation compared to normal pleural mesothelial cells. 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Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells

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