Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis

Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens,...
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Autor*in:	B. Linnane [verfasserIn] N.H. O'Connell [verfasserIn] E. Obande [verfasserIn] S.S. Dunne [verfasserIn] C. Clancy [verfasserIn] M.G. Kiernan [verfasserIn] D. McGrath [verfasserIn] K.J. O'Sullivan [verfasserIn] L. O'Sullivan [verfasserIn] C.P. Dunne [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning

Übergeordnetes Werk:	In: Infection Prevention in Practice - Elsevier, 2019, 3(2021), 3, Seite 100153-
Übergeordnetes Werk:	volume:3 ; year:2021 ; number:3 ; pages:100153-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.infpip.2021.100153

Katalog-ID:	DOAJ059497130

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520			\|a Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study.
650		4	\|a Cystic fibrosis
650		4	\|a Positive expiratory pressure (PEP)
650		4	\|a Oscillating intrapulmonary pressure (OPEP)
650		4	\|a Microbiology
650		4	\|a Hygiene
650		4	\|a Cleaning
653		0	\|a Infectious and parasitic diseases
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700	0		\|a K.J. O'Sullivan \|e verfasserin \|4 aut
700	0		\|a L. O'Sullivan \|e verfasserin \|4 aut
700	0		\|a C.P. Dunne \|e verfasserin \|4 aut
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allfields	10.1016/j.infpip.2021.100153 doi (DE-627)DOAJ059497130 (DE-599)DOAJd61ca0ad56d746758ec33824e5c82be9 DE-627 ger DE-627 rakwb eng RC109-216 RA1-1270 B. Linnane verfasserin aut Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study. Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning Infectious and parasitic diseases Public aspects of medicine N.H. O'Connell verfasserin aut E. Obande verfasserin aut S.S. Dunne verfasserin aut C. Clancy verfasserin aut M.G. Kiernan verfasserin aut D. McGrath verfasserin aut K.J. O'Sullivan verfasserin aut L. O'Sullivan verfasserin aut C.P. Dunne verfasserin aut In Infection Prevention in Practice Elsevier, 2019 3(2021), 3, Seite 100153- (DE-627)1755751702 25900889 nnns volume:3 year:2021 number:3 pages:100153- https://doi.org/10.1016/j.infpip.2021.100153 kostenfrei https://doaj.org/article/d61ca0ad56d746758ec33824e5c82be9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590088921000421 kostenfrei https://doaj.org/toc/2590-0889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2021 3 100153-
spelling	10.1016/j.infpip.2021.100153 doi (DE-627)DOAJ059497130 (DE-599)DOAJd61ca0ad56d746758ec33824e5c82be9 DE-627 ger DE-627 rakwb eng RC109-216 RA1-1270 B. Linnane verfasserin aut Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study. Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning Infectious and parasitic diseases Public aspects of medicine N.H. O'Connell verfasserin aut E. Obande verfasserin aut S.S. Dunne verfasserin aut C. Clancy verfasserin aut M.G. Kiernan verfasserin aut D. McGrath verfasserin aut K.J. O'Sullivan verfasserin aut L. O'Sullivan verfasserin aut C.P. Dunne verfasserin aut In Infection Prevention in Practice Elsevier, 2019 3(2021), 3, Seite 100153- (DE-627)1755751702 25900889 nnns volume:3 year:2021 number:3 pages:100153- https://doi.org/10.1016/j.infpip.2021.100153 kostenfrei https://doaj.org/article/d61ca0ad56d746758ec33824e5c82be9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590088921000421 kostenfrei https://doaj.org/toc/2590-0889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2021 3 100153-
allfields_unstemmed	10.1016/j.infpip.2021.100153 doi (DE-627)DOAJ059497130 (DE-599)DOAJd61ca0ad56d746758ec33824e5c82be9 DE-627 ger DE-627 rakwb eng RC109-216 RA1-1270 B. Linnane verfasserin aut Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study. Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning Infectious and parasitic diseases Public aspects of medicine N.H. O'Connell verfasserin aut E. Obande verfasserin aut S.S. Dunne verfasserin aut C. Clancy verfasserin aut M.G. Kiernan verfasserin aut D. McGrath verfasserin aut K.J. O'Sullivan verfasserin aut L. O'Sullivan verfasserin aut C.P. Dunne verfasserin aut In Infection Prevention in Practice Elsevier, 2019 3(2021), 3, Seite 100153- (DE-627)1755751702 25900889 nnns volume:3 year:2021 number:3 pages:100153- https://doi.org/10.1016/j.infpip.2021.100153 kostenfrei https://doaj.org/article/d61ca0ad56d746758ec33824e5c82be9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590088921000421 kostenfrei https://doaj.org/toc/2590-0889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2021 3 100153-
allfieldsGer	10.1016/j.infpip.2021.100153 doi (DE-627)DOAJ059497130 (DE-599)DOAJd61ca0ad56d746758ec33824e5c82be9 DE-627 ger DE-627 rakwb eng RC109-216 RA1-1270 B. Linnane verfasserin aut Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study. Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning Infectious and parasitic diseases Public aspects of medicine N.H. O'Connell verfasserin aut E. Obande verfasserin aut S.S. Dunne verfasserin aut C. Clancy verfasserin aut M.G. Kiernan verfasserin aut D. McGrath verfasserin aut K.J. O'Sullivan verfasserin aut L. O'Sullivan verfasserin aut C.P. Dunne verfasserin aut In Infection Prevention in Practice Elsevier, 2019 3(2021), 3, Seite 100153- (DE-627)1755751702 25900889 nnns volume:3 year:2021 number:3 pages:100153- https://doi.org/10.1016/j.infpip.2021.100153 kostenfrei https://doaj.org/article/d61ca0ad56d746758ec33824e5c82be9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590088921000421 kostenfrei https://doaj.org/toc/2590-0889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2021 3 100153-
allfieldsSound	10.1016/j.infpip.2021.100153 doi (DE-627)DOAJ059497130 (DE-599)DOAJd61ca0ad56d746758ec33824e5c82be9 DE-627 ger DE-627 rakwb eng RC109-216 RA1-1270 B. Linnane verfasserin aut Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study. Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning Infectious and parasitic diseases Public aspects of medicine N.H. O'Connell verfasserin aut E. Obande verfasserin aut S.S. Dunne verfasserin aut C. Clancy verfasserin aut M.G. Kiernan verfasserin aut D. McGrath verfasserin aut K.J. O'Sullivan verfasserin aut L. O'Sullivan verfasserin aut C.P. Dunne verfasserin aut In Infection Prevention in Practice Elsevier, 2019 3(2021), 3, Seite 100153- (DE-627)1755751702 25900889 nnns volume:3 year:2021 number:3 pages:100153- https://doi.org/10.1016/j.infpip.2021.100153 kostenfrei https://doaj.org/article/d61ca0ad56d746758ec33824e5c82be9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590088921000421 kostenfrei https://doaj.org/toc/2590-0889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2021 3 100153-
language	English
source	In Infection Prevention in Practice 3(2021), 3, Seite 100153- volume:3 year:2021 number:3 pages:100153-
sourceStr	In Infection Prevention in Practice 3(2021), 3, Seite 100153- volume:3 year:2021 number:3 pages:100153-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning Infectious and parasitic diseases Public aspects of medicine
isfreeaccess_bool	true
container_title	Infection Prevention in Practice
authorswithroles_txt_mv	B. Linnane @@aut@@ N.H. O'Connell @@aut@@ E. Obande @@aut@@ S.S. Dunne @@aut@@ C. Clancy @@aut@@ M.G. Kiernan @@aut@@ D. McGrath @@aut@@ K.J. O'Sullivan @@aut@@ L. O'Sullivan @@aut@@ C.P. Dunne @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1755751702
id	DOAJ059497130
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ059497130</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308233902.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.infpip.2021.100153</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ059497130</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJd61ca0ad56d746758ec33824e5c82be9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC109-216</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1-1270</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">B. Linnane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cystic fibrosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Positive expiratory pressure (PEP)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oscillating intrapulmonary pressure (OPEP)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Microbiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hygiene</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cleaning</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Infectious and parasitic diseases</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Public aspects of medicine</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">N.H. 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callnumber-first	R - Medicine
author	B. Linnane
spellingShingle	B. Linnane misc RC109-216 misc RA1-1270 misc Cystic fibrosis misc Positive expiratory pressure (PEP) misc Oscillating intrapulmonary pressure (OPEP) misc Microbiology misc Hygiene misc Cleaning misc Infectious and parasitic diseases misc Public aspects of medicine Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis
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topic_title	RC109-216 RA1-1270 Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis Cystic fibrosis Positive expiratory pressure (PEP) Oscillating intrapulmonary pressure (OPEP) Microbiology Hygiene Cleaning
topic	misc RC109-216 misc RA1-1270 misc Cystic fibrosis misc Positive expiratory pressure (PEP) misc Oscillating intrapulmonary pressure (OPEP) misc Microbiology misc Hygiene misc Cleaning misc Infectious and parasitic diseases misc Public aspects of medicine
topic_unstemmed	misc RC109-216 misc RA1-1270 misc Cystic fibrosis misc Positive expiratory pressure (PEP) misc Oscillating intrapulmonary pressure (OPEP) misc Microbiology misc Hygiene misc Cleaning misc Infectious and parasitic diseases misc Public aspects of medicine
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title	Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis
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title_full	Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis
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author_browse	B. Linnane N.H. O'Connell E. Obande S.S. Dunne C. Clancy M.G. Kiernan D. McGrath K.J. O'Sullivan L. O'Sullivan C.P. Dunne
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title_sort	assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis
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title_auth	Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis
abstract	Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study.
abstractGer	Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study.
abstract_unstemmed	Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. The potential for transmission of these pathogens to the patient's airway and the risk of infection remains unclear and requires further study.
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title_short	Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis
url	https://doi.org/10.1016/j.infpip.2021.100153 https://doaj.org/article/d61ca0ad56d746758ec33824e5c82be9 http://www.sciencedirect.com/science/article/pii/S2590088921000421 https://doaj.org/toc/2590-0889
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Linnane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: Background: Positive expiratory pressure (PEP) devices are an important element of the management of cystic fibrosis, and of other respiratory diseases. Whereas there have been reports in the literature of contamination of airway clearance devices and their surfaces by microbial pathogens, there is little evidence available regarding such contamination and its contribution to respiratory infection. Aim: To establish whether pathogenic bacteria can contaminate PEP devices in the context of normal cleaning and maintenance practices. Methods: Patients' home-use clearance devices were brought to a routine clinic appointment and collected for microbiology sampling and analysis. The patients were provided with replacement devices. Nineteen such devices were collected from 17 patients, reflecting use of multiple devices by some patients. Swabs were taken and cultured from each patient's used device, the patient's airway, as well as from new unopened and unused devices that acted as controls. Results: Seven of 19 devices (37%) tested positive for presence of pathogenic bacteria. Device-cleaning methods varied among patients and non-sterilization methods were found to be ineffective at removing pathogens. Microbial species found on the devices did not correlate with those identified from airway swabs. Conclusion: This study demonstrates the presence of pathogens on positive expiratory pressure devices. 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Assessment of the microbial load of airway clearance devices used by a cohort of children with cystic fibrosis

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