Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase...
Ausführliche Beschreibung
Autor*in: |
Mark M. Hughes [verfasserIn] Alexander Hooftman [verfasserIn] Stefano Angiari [verfasserIn] Padmaja Tummala [verfasserIn] Zbigniew Zaslona [verfasserIn] Marah C. Runtsch [verfasserIn] Anne F. McGettrick [verfasserIn] Caroline E. Sutton [verfasserIn] Ciana Diskin [verfasserIn] Melissa Rooke [verfasserIn] Shuhei Takahashi [verfasserIn] Srinivasan Sundararaj [verfasserIn] Marco G. Casarotto [verfasserIn] Jane E. Dahlstrom [verfasserIn] Eva M. Palsson-McDermott [verfasserIn] Sinead C. Corr [verfasserIn] Kingston H.G. Mills [verfasserIn] Roger J.S. Preston [verfasserIn] Nouri Neamati [verfasserIn] Yiyue Xie [verfasserIn] Jonathan B. Baell [verfasserIn] Philip G. Board [verfasserIn] Luke A.J. O’Neill [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: Cell Reports - Elsevier, 2015, 29(2019), 1, Seite 151-161.e5 |
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Übergeordnetes Werk: |
volume:29 ; year:2019 ; number:1 ; pages:151-161.e5 |
Links: |
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DOI / URN: |
10.1016/j.celrep.2019.08.072 |
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Katalog-ID: |
DOAJ05951812X |
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520 | |a Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis | ||
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700 | 0 | |a Stefano Angiari |e verfasserin |4 aut | |
700 | 0 | |a Padmaja Tummala |e verfasserin |4 aut | |
700 | 0 | |a Zbigniew Zaslona |e verfasserin |4 aut | |
700 | 0 | |a Marah C. Runtsch |e verfasserin |4 aut | |
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700 | 0 | |a Caroline E. Sutton |e verfasserin |4 aut | |
700 | 0 | |a Ciana Diskin |e verfasserin |4 aut | |
700 | 0 | |a Melissa Rooke |e verfasserin |4 aut | |
700 | 0 | |a Shuhei Takahashi |e verfasserin |4 aut | |
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700 | 0 | |a Yiyue Xie |e verfasserin |4 aut | |
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10.1016/j.celrep.2019.08.072 doi (DE-627)DOAJ05951812X (DE-599)DOAJ655fe3fa8e5148bd966bc89b672d9785 DE-627 ger DE-627 rakwb eng QH301-705.5 Mark M. Hughes verfasserin aut Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis Biology (General) Alexander Hooftman verfasserin aut Stefano Angiari verfasserin aut Padmaja Tummala verfasserin aut Zbigniew Zaslona verfasserin aut Marah C. Runtsch verfasserin aut Anne F. McGettrick verfasserin aut Caroline E. Sutton verfasserin aut Ciana Diskin verfasserin aut Melissa Rooke verfasserin aut Shuhei Takahashi verfasserin aut Srinivasan Sundararaj verfasserin aut Marco G. Casarotto verfasserin aut Jane E. Dahlstrom verfasserin aut Eva M. Palsson-McDermott verfasserin aut Sinead C. Corr verfasserin aut Kingston H.G. Mills verfasserin aut Roger J.S. Preston verfasserin aut Nouri Neamati verfasserin aut Yiyue Xie verfasserin aut Jonathan B. Baell verfasserin aut Philip G. Board verfasserin aut Luke A.J. O’Neill verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 1, Seite 151-161.e5 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:1 pages:151-161.e5 https://doi.org/10.1016/j.celrep.2019.08.072 kostenfrei https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719311271 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 1 151-161.e5 |
spelling |
10.1016/j.celrep.2019.08.072 doi (DE-627)DOAJ05951812X (DE-599)DOAJ655fe3fa8e5148bd966bc89b672d9785 DE-627 ger DE-627 rakwb eng QH301-705.5 Mark M. Hughes verfasserin aut Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis Biology (General) Alexander Hooftman verfasserin aut Stefano Angiari verfasserin aut Padmaja Tummala verfasserin aut Zbigniew Zaslona verfasserin aut Marah C. Runtsch verfasserin aut Anne F. McGettrick verfasserin aut Caroline E. Sutton verfasserin aut Ciana Diskin verfasserin aut Melissa Rooke verfasserin aut Shuhei Takahashi verfasserin aut Srinivasan Sundararaj verfasserin aut Marco G. Casarotto verfasserin aut Jane E. Dahlstrom verfasserin aut Eva M. Palsson-McDermott verfasserin aut Sinead C. Corr verfasserin aut Kingston H.G. Mills verfasserin aut Roger J.S. Preston verfasserin aut Nouri Neamati verfasserin aut Yiyue Xie verfasserin aut Jonathan B. Baell verfasserin aut Philip G. Board verfasserin aut Luke A.J. O’Neill verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 1, Seite 151-161.e5 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:1 pages:151-161.e5 https://doi.org/10.1016/j.celrep.2019.08.072 kostenfrei https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719311271 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 1 151-161.e5 |
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10.1016/j.celrep.2019.08.072 doi (DE-627)DOAJ05951812X (DE-599)DOAJ655fe3fa8e5148bd966bc89b672d9785 DE-627 ger DE-627 rakwb eng QH301-705.5 Mark M. Hughes verfasserin aut Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis Biology (General) Alexander Hooftman verfasserin aut Stefano Angiari verfasserin aut Padmaja Tummala verfasserin aut Zbigniew Zaslona verfasserin aut Marah C. Runtsch verfasserin aut Anne F. McGettrick verfasserin aut Caroline E. Sutton verfasserin aut Ciana Diskin verfasserin aut Melissa Rooke verfasserin aut Shuhei Takahashi verfasserin aut Srinivasan Sundararaj verfasserin aut Marco G. Casarotto verfasserin aut Jane E. Dahlstrom verfasserin aut Eva M. Palsson-McDermott verfasserin aut Sinead C. Corr verfasserin aut Kingston H.G. Mills verfasserin aut Roger J.S. Preston verfasserin aut Nouri Neamati verfasserin aut Yiyue Xie verfasserin aut Jonathan B. Baell verfasserin aut Philip G. Board verfasserin aut Luke A.J. O’Neill verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 1, Seite 151-161.e5 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:1 pages:151-161.e5 https://doi.org/10.1016/j.celrep.2019.08.072 kostenfrei https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719311271 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 1 151-161.e5 |
allfieldsGer |
10.1016/j.celrep.2019.08.072 doi (DE-627)DOAJ05951812X (DE-599)DOAJ655fe3fa8e5148bd966bc89b672d9785 DE-627 ger DE-627 rakwb eng QH301-705.5 Mark M. Hughes verfasserin aut Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis Biology (General) Alexander Hooftman verfasserin aut Stefano Angiari verfasserin aut Padmaja Tummala verfasserin aut Zbigniew Zaslona verfasserin aut Marah C. Runtsch verfasserin aut Anne F. McGettrick verfasserin aut Caroline E. Sutton verfasserin aut Ciana Diskin verfasserin aut Melissa Rooke verfasserin aut Shuhei Takahashi verfasserin aut Srinivasan Sundararaj verfasserin aut Marco G. Casarotto verfasserin aut Jane E. Dahlstrom verfasserin aut Eva M. Palsson-McDermott verfasserin aut Sinead C. Corr verfasserin aut Kingston H.G. Mills verfasserin aut Roger J.S. Preston verfasserin aut Nouri Neamati verfasserin aut Yiyue Xie verfasserin aut Jonathan B. Baell verfasserin aut Philip G. Board verfasserin aut Luke A.J. O’Neill verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 1, Seite 151-161.e5 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:1 pages:151-161.e5 https://doi.org/10.1016/j.celrep.2019.08.072 kostenfrei https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719311271 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 1 151-161.e5 |
allfieldsSound |
10.1016/j.celrep.2019.08.072 doi (DE-627)DOAJ05951812X (DE-599)DOAJ655fe3fa8e5148bd966bc89b672d9785 DE-627 ger DE-627 rakwb eng QH301-705.5 Mark M. Hughes verfasserin aut Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis Biology (General) Alexander Hooftman verfasserin aut Stefano Angiari verfasserin aut Padmaja Tummala verfasserin aut Zbigniew Zaslona verfasserin aut Marah C. Runtsch verfasserin aut Anne F. McGettrick verfasserin aut Caroline E. Sutton verfasserin aut Ciana Diskin verfasserin aut Melissa Rooke verfasserin aut Shuhei Takahashi verfasserin aut Srinivasan Sundararaj verfasserin aut Marco G. Casarotto verfasserin aut Jane E. Dahlstrom verfasserin aut Eva M. Palsson-McDermott verfasserin aut Sinead C. Corr verfasserin aut Kingston H.G. Mills verfasserin aut Roger J.S. Preston verfasserin aut Nouri Neamati verfasserin aut Yiyue Xie verfasserin aut Jonathan B. Baell verfasserin aut Philip G. Board verfasserin aut Luke A.J. O’Neill verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 1, Seite 151-161.e5 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:1 pages:151-161.e5 https://doi.org/10.1016/j.celrep.2019.08.072 kostenfrei https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719311271 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 1 151-161.e5 |
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Mark M. Hughes @@aut@@ Alexander Hooftman @@aut@@ Stefano Angiari @@aut@@ Padmaja Tummala @@aut@@ Zbigniew Zaslona @@aut@@ Marah C. Runtsch @@aut@@ Anne F. McGettrick @@aut@@ Caroline E. Sutton @@aut@@ Ciana Diskin @@aut@@ Melissa Rooke @@aut@@ Shuhei Takahashi @@aut@@ Srinivasan Sundararaj @@aut@@ Marco G. Casarotto @@aut@@ Jane E. Dahlstrom @@aut@@ Eva M. Palsson-McDermott @@aut@@ Sinead C. Corr @@aut@@ Kingston H.G. Mills @@aut@@ Roger J.S. Preston @@aut@@ Nouri Neamati @@aut@@ Yiyue Xie @@aut@@ Jonathan B. Baell @@aut@@ Philip G. Board @@aut@@ Luke A.J. O’Neill @@aut@@ |
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Hughes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. 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Mark M. Hughes misc QH301-705.5 misc Biology (General) Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation |
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QH301-705.5 Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation |
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation |
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation |
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Mark M. Hughes Alexander Hooftman Stefano Angiari Padmaja Tummala Zbigniew Zaslona Marah C. Runtsch Anne F. McGettrick Caroline E. Sutton Ciana Diskin Melissa Rooke Shuhei Takahashi Srinivasan Sundararaj Marco G. Casarotto Jane E. Dahlstrom Eva M. Palsson-McDermott Sinead C. Corr Kingston H.G. Mills Roger J.S. Preston Nouri Neamati Yiyue Xie Jonathan B. Baell Philip G. Board Luke A.J. O’Neill |
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glutathione transferase omega-1 regulates nlrp3 inflammasome activation through nek7 deglutathionylation |
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation |
abstract |
Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis |
abstractGer |
Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis |
abstract_unstemmed |
Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. Furthermore, the GSTO1-1 inhibitor C1-27 reduces NLRP3 inflammasome activation in vitro and in vivo. Keywords: NLRP3 inflammasome, GSTO1-1, glutathione, NEK7, IL-1β, deglutathionylation, pyroptosis |
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation |
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https://doi.org/10.1016/j.celrep.2019.08.072 https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785 http://www.sciencedirect.com/science/article/pii/S2211124719311271 https://doaj.org/toc/2211-1247 |
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Alexander Hooftman Stefano Angiari Padmaja Tummala Zbigniew Zaslona Marah C. Runtsch Anne F. McGettrick Caroline E. Sutton Ciana Diskin Melissa Rooke Shuhei Takahashi Srinivasan Sundararaj Marco G. Casarotto Jane E. Dahlstrom Eva M. Palsson-McDermott Sinead C. Corr Kingston H.G. Mills Roger J.S. Preston Nouri Neamati Yiyue Xie Jonathan B. Baell Philip G. Board Luke A.J. O’Neill |
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Alexander Hooftman Stefano Angiari Padmaja Tummala Zbigniew Zaslona Marah C. Runtsch Anne F. McGettrick Caroline E. Sutton Ciana Diskin Melissa Rooke Shuhei Takahashi Srinivasan Sundararaj Marco G. Casarotto Jane E. Dahlstrom Eva M. Palsson-McDermott Sinead C. Corr Kingston H.G. Mills Roger J.S. Preston Nouri Neamati Yiyue Xie Jonathan B. Baell Philip G. Board Luke A.J. O’Neill |
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Hughes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1−/− mice, we report that GSTO1-1 is involved in NLRP3 inflammasome activation. Mechanistically, GSTO1-1 deglutathionylates cysteine 253 in NIMA related kinase 7 (NEK7) to promote NLRP3 activation. We therefore identify GSTO1-1 as an NLRP3 inflammasome regulator, which has potential as a drug target to limit NLRP3-mediated inflammation. : NLRP3 inflammasome activation contributes to chronic inflammation associated with autoinflammatory disease, yet understanding of NLRP3 inflammasome regulation is incomplete. Hughes et al. show that the deglutathionylating enzyme GSTO1-1 promotes NLRP3 inflammasome activation through deglutathionylation of NEK7. 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