The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.

Gespeichert in:

Autor*in:	Nina Mars [verfasserIn] Elisabeth Widén [verfasserIn] Sini Kerminen [verfasserIn] Tuomo Meretoja [verfasserIn] Matti Pirinen [verfasserIn] Pietro della Briotta Parolo [verfasserIn] Priit Palta [verfasserIn] FinnGen [verfasserIn] Aarno Palotie [verfasserIn] Jaakko Kaprio [verfasserIn] Heikki Joensuu [verfasserIn] Mark Daly [verfasserIn] Samuli Ripatti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 11(2020), 1, Seite 9
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-020-19966-5

Katalog-ID:	DOAJ059709421

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title	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
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title_sort	role of polygenic risk and susceptibility genes in breast cancer over the course of life
title_auth	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
abstract	Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.
abstractGer	Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.
abstract_unstemmed	Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.
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title_short	The role of polygenic risk and susceptibility genes in breast cancer over the course of life
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The role of polygenic risk and susceptibility genes in breast cancer over the course of life

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