The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency

Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and norma...
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Autor*in:	Izabela Morawska [verfasserIn] Sara Kurkowska [verfasserIn] Dominika Bębnowska [verfasserIn] Rafał Hrynkiewicz [verfasserIn] Rafał Becht [verfasserIn] Adam Michalski [verfasserIn] Hanna Piwowarska-Bilska [verfasserIn] Bożena Birkenfeld [verfasserIn] Katarzyna Załuska-Ogryzek [verfasserIn] Ewelina Grywalska [verfasserIn] Jacek Roliński [verfasserIn] Paulina Niedźwiedzka-Rystwej [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	atopic diseases atopy allergy selective IgA deficiency primary immunodeficiency

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 17, p 3809
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:17, p 3809

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10173809

Katalog-ID:	DOAJ059717092

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520			\|a Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases.
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allfields	10.3390/jcm10173809 doi (DE-627)DOAJ059717092 (DE-599)DOAJc088177578c04f16931b6d04ac2380fe DE-627 ger DE-627 rakwb eng Izabela Morawska verfasserin aut The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases. atopic diseases atopy allergy selective IgA deficiency primary immunodeficiency Medicine R Sara Kurkowska verfasserin aut Dominika Bębnowska verfasserin aut Rafał Hrynkiewicz verfasserin aut Rafał Becht verfasserin aut Adam Michalski verfasserin aut Hanna Piwowarska-Bilska verfasserin aut Bożena Birkenfeld verfasserin aut Katarzyna Załuska-Ogryzek verfasserin aut Ewelina Grywalska verfasserin aut Jacek Roliński verfasserin aut Paulina Niedźwiedzka-Rystwej verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 17, p 3809 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:17, p 3809 https://doi.org/10.3390/jcm10173809 kostenfrei https://doaj.org/article/c088177578c04f16931b6d04ac2380fe kostenfrei https://www.mdpi.com/2077-0383/10/17/3809 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 17, p 3809
spelling	10.3390/jcm10173809 doi (DE-627)DOAJ059717092 (DE-599)DOAJc088177578c04f16931b6d04ac2380fe DE-627 ger DE-627 rakwb eng Izabela Morawska verfasserin aut The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases. atopic diseases atopy allergy selective IgA deficiency primary immunodeficiency Medicine R Sara Kurkowska verfasserin aut Dominika Bębnowska verfasserin aut Rafał Hrynkiewicz verfasserin aut Rafał Becht verfasserin aut Adam Michalski verfasserin aut Hanna Piwowarska-Bilska verfasserin aut Bożena Birkenfeld verfasserin aut Katarzyna Załuska-Ogryzek verfasserin aut Ewelina Grywalska verfasserin aut Jacek Roliński verfasserin aut Paulina Niedźwiedzka-Rystwej verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 17, p 3809 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:17, p 3809 https://doi.org/10.3390/jcm10173809 kostenfrei https://doaj.org/article/c088177578c04f16931b6d04ac2380fe kostenfrei https://www.mdpi.com/2077-0383/10/17/3809 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 17, p 3809
allfields_unstemmed	10.3390/jcm10173809 doi (DE-627)DOAJ059717092 (DE-599)DOAJc088177578c04f16931b6d04ac2380fe DE-627 ger DE-627 rakwb eng Izabela Morawska verfasserin aut The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases. atopic diseases atopy allergy selective IgA deficiency primary immunodeficiency Medicine R Sara Kurkowska verfasserin aut Dominika Bębnowska verfasserin aut Rafał Hrynkiewicz verfasserin aut Rafał Becht verfasserin aut Adam Michalski verfasserin aut Hanna Piwowarska-Bilska verfasserin aut Bożena Birkenfeld verfasserin aut Katarzyna Załuska-Ogryzek verfasserin aut Ewelina Grywalska verfasserin aut Jacek Roliński verfasserin aut Paulina Niedźwiedzka-Rystwej verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 17, p 3809 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:17, p 3809 https://doi.org/10.3390/jcm10173809 kostenfrei https://doaj.org/article/c088177578c04f16931b6d04ac2380fe kostenfrei https://www.mdpi.com/2077-0383/10/17/3809 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 17, p 3809
allfieldsGer	10.3390/jcm10173809 doi (DE-627)DOAJ059717092 (DE-599)DOAJc088177578c04f16931b6d04ac2380fe DE-627 ger DE-627 rakwb eng Izabela Morawska verfasserin aut The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases. atopic diseases atopy allergy selective IgA deficiency primary immunodeficiency Medicine R Sara Kurkowska verfasserin aut Dominika Bębnowska verfasserin aut Rafał Hrynkiewicz verfasserin aut Rafał Becht verfasserin aut Adam Michalski verfasserin aut Hanna Piwowarska-Bilska verfasserin aut Bożena Birkenfeld verfasserin aut Katarzyna Załuska-Ogryzek verfasserin aut Ewelina Grywalska verfasserin aut Jacek Roliński verfasserin aut Paulina Niedźwiedzka-Rystwej verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 17, p 3809 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:17, p 3809 https://doi.org/10.3390/jcm10173809 kostenfrei https://doaj.org/article/c088177578c04f16931b6d04ac2380fe kostenfrei https://www.mdpi.com/2077-0383/10/17/3809 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 17, p 3809
allfieldsSound	10.3390/jcm10173809 doi (DE-627)DOAJ059717092 (DE-599)DOAJc088177578c04f16931b6d04ac2380fe DE-627 ger DE-627 rakwb eng Izabela Morawska verfasserin aut The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases. atopic diseases atopy allergy selective IgA deficiency primary immunodeficiency Medicine R Sara Kurkowska verfasserin aut Dominika Bębnowska verfasserin aut Rafał Hrynkiewicz verfasserin aut Rafał Becht verfasserin aut Adam Michalski verfasserin aut Hanna Piwowarska-Bilska verfasserin aut Bożena Birkenfeld verfasserin aut Katarzyna Załuska-Ogryzek verfasserin aut Ewelina Grywalska verfasserin aut Jacek Roliński verfasserin aut Paulina Niedźwiedzka-Rystwej verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 17, p 3809 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:17, p 3809 https://doi.org/10.3390/jcm10173809 kostenfrei https://doaj.org/article/c088177578c04f16931b6d04ac2380fe kostenfrei https://www.mdpi.com/2077-0383/10/17/3809 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 17, p 3809
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author	Izabela Morawska
spellingShingle	Izabela Morawska misc atopic diseases misc atopy misc allergy misc selective IgA deficiency misc primary immunodeficiency misc Medicine misc R The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency
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topic_title	The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency atopic diseases atopy allergy selective IgA deficiency primary immunodeficiency
topic	misc atopic diseases misc atopy misc allergy misc selective IgA deficiency misc primary immunodeficiency misc Medicine misc R
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title	The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency
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title_sort	epidemiology and clinical presentations of atopic diseases in selective iga deficiency
title_auth	The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency
abstract	Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases.
abstractGer	Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases.
abstract_unstemmed	Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. The aim of the study is to summarize the connection between selective IgA deficiency and atopic diseases.
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title_short	The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency
url	https://doi.org/10.3390/jcm10173809 https://doaj.org/article/c088177578c04f16931b6d04ac2380fe https://www.mdpi.com/2077-0383/10/17/3809 https://doaj.org/toc/2077-0383
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Usually, the disease remains undiagnosed throughout the patient’s life, due to its frequent asymptomatic course. If symptomatic, sIgAD is connected to more frequent viral and bacterial infections of upper respiratory, urinary, and gastrointestinal tracts, as well as autoimmune and allergic diseases. Interestingly, it may also be associated with other PIDs, such as IgG subclasses deficiency or specific antibodies deficiency. Rarely sIgAD can evolve to common variable immunodeficiency disease (CVID). It should also be remembered that IgA deficiency may occur in the course of other conditions or result from their treatment. It is hypothesized that allergic diseases (e.g., eczema, rhinitis, asthma) are more common in patients diagnosed with this particular PID. Selective IgA deficiency, although usually mildly symptomatic, can be difficult for clinicians. 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The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency

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