Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation

Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to h...
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Autor*in:	Fatma Mohamed Sherif [verfasserIn] Sabry Alameldeen Elmogy [verfasserIn] Rihame Mohamed Abd EL-wahab [verfasserIn] Mohamed Abdel Wahab [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation

Übergeordnetes Werk:	In: The Egyptian Journal of Radiology and Nuclear Medicine - SpringerOpen, 2016, 50(2019), 1, Seite 6
Übergeordnetes Werk:	volume:50 ; year:2019 ; number:1 ; pages:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s43055-019-0061-4

Katalog-ID:	DOAJ059722347

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520			\|a Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors.
650		4	\|a Hepatic steatosis
650		4	\|a Magnetic resonance proton density fat fraction technique (MR PDFF)
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allfields	10.1186/s43055-019-0061-4 doi (DE-627)DOAJ059722347 (DE-599)DOAJ16266410436d4254a6de0e2c486d1647 DE-627 ger DE-627 rakwb eng R895-920 Fatma Mohamed Sherif verfasserin aut Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors. Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation Medical physics. Medical radiology. Nuclear medicine Sabry Alameldeen Elmogy verfasserin aut Rihame Mohamed Abd EL-wahab verfasserin aut Mohamed Abdel Wahab verfasserin aut In The Egyptian Journal of Radiology and Nuclear Medicine SpringerOpen, 2016 50(2019), 1, Seite 6 (DE-627)641391862 (DE-600)2583928-7 20904762 nnns volume:50 year:2019 number:1 pages:6 https://doi.org/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/article/16266410436d4254a6de0e2c486d1647 kostenfrei http://link.springer.com/article/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/toc/2090-4762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2019 1 6
spelling	10.1186/s43055-019-0061-4 doi (DE-627)DOAJ059722347 (DE-599)DOAJ16266410436d4254a6de0e2c486d1647 DE-627 ger DE-627 rakwb eng R895-920 Fatma Mohamed Sherif verfasserin aut Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors. Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation Medical physics. Medical radiology. Nuclear medicine Sabry Alameldeen Elmogy verfasserin aut Rihame Mohamed Abd EL-wahab verfasserin aut Mohamed Abdel Wahab verfasserin aut In The Egyptian Journal of Radiology and Nuclear Medicine SpringerOpen, 2016 50(2019), 1, Seite 6 (DE-627)641391862 (DE-600)2583928-7 20904762 nnns volume:50 year:2019 number:1 pages:6 https://doi.org/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/article/16266410436d4254a6de0e2c486d1647 kostenfrei http://link.springer.com/article/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/toc/2090-4762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2019 1 6
allfields_unstemmed	10.1186/s43055-019-0061-4 doi (DE-627)DOAJ059722347 (DE-599)DOAJ16266410436d4254a6de0e2c486d1647 DE-627 ger DE-627 rakwb eng R895-920 Fatma Mohamed Sherif verfasserin aut Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors. Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation Medical physics. Medical radiology. Nuclear medicine Sabry Alameldeen Elmogy verfasserin aut Rihame Mohamed Abd EL-wahab verfasserin aut Mohamed Abdel Wahab verfasserin aut In The Egyptian Journal of Radiology and Nuclear Medicine SpringerOpen, 2016 50(2019), 1, Seite 6 (DE-627)641391862 (DE-600)2583928-7 20904762 nnns volume:50 year:2019 number:1 pages:6 https://doi.org/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/article/16266410436d4254a6de0e2c486d1647 kostenfrei http://link.springer.com/article/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/toc/2090-4762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2019 1 6
allfieldsGer	10.1186/s43055-019-0061-4 doi (DE-627)DOAJ059722347 (DE-599)DOAJ16266410436d4254a6de0e2c486d1647 DE-627 ger DE-627 rakwb eng R895-920 Fatma Mohamed Sherif verfasserin aut Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors. Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation Medical physics. Medical radiology. Nuclear medicine Sabry Alameldeen Elmogy verfasserin aut Rihame Mohamed Abd EL-wahab verfasserin aut Mohamed Abdel Wahab verfasserin aut In The Egyptian Journal of Radiology and Nuclear Medicine SpringerOpen, 2016 50(2019), 1, Seite 6 (DE-627)641391862 (DE-600)2583928-7 20904762 nnns volume:50 year:2019 number:1 pages:6 https://doi.org/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/article/16266410436d4254a6de0e2c486d1647 kostenfrei http://link.springer.com/article/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/toc/2090-4762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2019 1 6
allfieldsSound	10.1186/s43055-019-0061-4 doi (DE-627)DOAJ059722347 (DE-599)DOAJ16266410436d4254a6de0e2c486d1647 DE-627 ger DE-627 rakwb eng R895-920 Fatma Mohamed Sherif verfasserin aut Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors. Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation Medical physics. Medical radiology. Nuclear medicine Sabry Alameldeen Elmogy verfasserin aut Rihame Mohamed Abd EL-wahab verfasserin aut Mohamed Abdel Wahab verfasserin aut In The Egyptian Journal of Radiology and Nuclear Medicine SpringerOpen, 2016 50(2019), 1, Seite 6 (DE-627)641391862 (DE-600)2583928-7 20904762 nnns volume:50 year:2019 number:1 pages:6 https://doi.org/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/article/16266410436d4254a6de0e2c486d1647 kostenfrei http://link.springer.com/article/10.1186/s43055-019-0061-4 kostenfrei https://doaj.org/toc/2090-4762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 50 2019 1 6
language	English
source	In The Egyptian Journal of Radiology and Nuclear Medicine 50(2019), 1, Seite 6 volume:50 year:2019 number:1 pages:6
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topic_facet	Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation Medical physics. Medical radiology. Nuclear medicine
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This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). 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callnumber-first	R - Medicine
author	Fatma Mohamed Sherif
spellingShingle	Fatma Mohamed Sherif misc R895-920 misc Hepatic steatosis misc Magnetic resonance proton density fat fraction technique (MR PDFF) misc Living donors misc Liver transplantation misc Medical physics. Medical radiology. Nuclear medicine Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation
authorStr	Fatma Mohamed Sherif
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topic_title	R895-920 Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation Hepatic steatosis Magnetic resonance proton density fat fraction technique (MR PDFF) Living donors Liver transplantation
topic	misc R895-920 misc Hepatic steatosis misc Magnetic resonance proton density fat fraction technique (MR PDFF) misc Living donors misc Liver transplantation misc Medical physics. Medical radiology. Nuclear medicine
topic_unstemmed	misc R895-920 misc Hepatic steatosis misc Magnetic resonance proton density fat fraction technique (MR PDFF) misc Living donors misc Liver transplantation misc Medical physics. Medical radiology. Nuclear medicine
topic_browse	misc R895-920 misc Hepatic steatosis misc Magnetic resonance proton density fat fraction technique (MR PDFF) misc Living donors misc Liver transplantation misc Medical physics. Medical radiology. Nuclear medicine
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title	Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation
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title_full	Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation
author_sort	Fatma Mohamed Sherif
journal	The Egyptian Journal of Radiology and Nuclear Medicine
journalStr	The Egyptian Journal of Radiology and Nuclear Medicine
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author_browse	Fatma Mohamed Sherif Sabry Alameldeen Elmogy Rihame Mohamed Abd EL-wahab Mohamed Abdel Wahab
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author-letter	Fatma Mohamed Sherif
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title_sort	utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation
callnumber	R895-920
title_auth	Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation
abstract	Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors.
abstractGer	Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors.
abstract_unstemmed	Abstract Background Hepatic steatosis in living donors for liver transplantation causes morbidity of both donor and recipient. This study aims at evaluating magnetic resonance proton density fat fraction technique (MR PDFF) in quantitative evaluation of living donor’s hepatic steatosis compared to histopathology. Results The examined potential living liver donors’ liver biopsies revealed hepatic steatosis < 5% (grade 0) in 40 donors and 5–10% (grade 1) in 7 donors. MR PDFF technique with IDEAL sequence showed excellent results for prediction and quantitative evaluation of liver fat with sensitivity, specificity, and accuracy of 85.7%, 97.5%, and 95.7%, respectively, compared to histopathology (95% confidence interval 0.98–1.01). There was an excellent inter-reader agreement between both readers in estimation of MR liver fat fraction (r = 0.969 at 95% confidence interval 0.946–0.983). Conclusion Noninvasive hepatic MR PDFF technique with IDEAL sequence is a precise reliable technique for pre-operative quantitative assessment of hepatic steatosis in potential living liver donors.
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title_short	Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation
url	https://doi.org/10.1186/s43055-019-0061-4 https://doaj.org/article/16266410436d4254a6de0e2c486d1647 http://link.springer.com/article/10.1186/s43055-019-0061-4 https://doaj.org/toc/2090-4762
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author2	Sabry Alameldeen Elmogy Rihame Mohamed Abd EL-wahab Mohamed Abdel Wahab
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up_date	2024-07-04T00:38:53.159Z
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Utility of magnetic resonance proton density fat fraction technique in quantification of liver fat in living donors for liver transplantation

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