The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH

The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. How...
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Autor*in:	Khalid O. Alfarouk [verfasserIn] Samrein B. M. Ahmed [verfasserIn] Robert L. Elliott [verfasserIn] Amanda Benoit [verfasserIn] Saad S. Alqahtani [verfasserIn] Muntaser E. Ibrahim [verfasserIn] Adil H. H. Bashir [verfasserIn] Sari T. S. Alhoufie [verfasserIn] Gamal O. Elhassan [verfasserIn] Christian C. Wales [verfasserIn] Laurent H. Schwartz [verfasserIn] Heyam S. Ali [verfasserIn] Ahmed Ahmed [verfasserIn] Patrick F. Forde [verfasserIn] Jesus Devesa [verfasserIn] Rosa A. Cardone [verfasserIn] Stefano Fais [verfasserIn] Salvador Harguindey [verfasserIn] Stephan J. Reshkin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	cancer metabolism enzyme pH redox

Übergeordnetes Werk:	In: Metabolites - MDPI AG, 2012, 10(2020), 7, p 285
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:7, p 285

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/metabo10070285

Katalog-ID:	DOAJ059730838

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allfields	10.3390/metabo10070285 doi (DE-627)DOAJ059730838 (DE-599)DOAJ97aae85c7d4744afaf11a9c2481043d5 DE-627 ger DE-627 rakwb eng QR1-502 Khalid O. Alfarouk verfasserin aut The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. However, cytoplasmic glucose utilization can also occur in cancer through the PPP. This pathway contributes to cancer cells by operating in many different ways: (i) as a defense mechanism via the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to prevent apoptosis, (ii) as a provision for the maintenance of energy by intermediate glycolysis, (iii) by increasing genomic material to the cellular pool of nucleic acid bases, (iv) by promoting survival through increasing glycolysis, and so increasing acid production, and (v) by inducing cellular proliferation by the synthesis of nucleic acid, fatty acid, and amino acid. Each step of the PPP can be upregulated in some types of cancer but not in others. An interesting aspect of this metabolic pathway is the shared regulation of the glycolytic and PPP pathways by intracellular pH (pHi). Indeed, as with glycolysis, the optimum activity of the enzymes driving the PPP occurs at an alkaline pHi, which is compatible with the cytoplasmic pH of cancer cells. Here, we outline each step of the PPP and discuss its possible correlation with cancer. cancer metabolism enzyme pH redox Microbiology Samrein B. M. Ahmed verfasserin aut Robert L. Elliott verfasserin aut Amanda Benoit verfasserin aut Saad S. Alqahtani verfasserin aut Muntaser E. Ibrahim verfasserin aut Adil H. H. Bashir verfasserin aut Sari T. S. Alhoufie verfasserin aut Gamal O. Elhassan verfasserin aut Christian C. Wales verfasserin aut Laurent H. Schwartz verfasserin aut Heyam S. Ali verfasserin aut Ahmed Ahmed verfasserin aut Patrick F. Forde verfasserin aut Jesus Devesa verfasserin aut Rosa A. Cardone verfasserin aut Stefano Fais verfasserin aut Salvador Harguindey verfasserin aut Stephan J. Reshkin verfasserin aut In Metabolites MDPI AG, 2012 10(2020), 7, p 285 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:10 year:2020 number:7, p 285 https://doi.org/10.3390/metabo10070285 kostenfrei https://doaj.org/article/97aae85c7d4744afaf11a9c2481043d5 kostenfrei https://www.mdpi.com/2218-1989/10/7/285 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 7, p 285
spelling	10.3390/metabo10070285 doi (DE-627)DOAJ059730838 (DE-599)DOAJ97aae85c7d4744afaf11a9c2481043d5 DE-627 ger DE-627 rakwb eng QR1-502 Khalid O. Alfarouk verfasserin aut The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. However, cytoplasmic glucose utilization can also occur in cancer through the PPP. This pathway contributes to cancer cells by operating in many different ways: (i) as a defense mechanism via the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to prevent apoptosis, (ii) as a provision for the maintenance of energy by intermediate glycolysis, (iii) by increasing genomic material to the cellular pool of nucleic acid bases, (iv) by promoting survival through increasing glycolysis, and so increasing acid production, and (v) by inducing cellular proliferation by the synthesis of nucleic acid, fatty acid, and amino acid. Each step of the PPP can be upregulated in some types of cancer but not in others. An interesting aspect of this metabolic pathway is the shared regulation of the glycolytic and PPP pathways by intracellular pH (pHi). Indeed, as with glycolysis, the optimum activity of the enzymes driving the PPP occurs at an alkaline pHi, which is compatible with the cytoplasmic pH of cancer cells. Here, we outline each step of the PPP and discuss its possible correlation with cancer. cancer metabolism enzyme pH redox Microbiology Samrein B. M. Ahmed verfasserin aut Robert L. Elliott verfasserin aut Amanda Benoit verfasserin aut Saad S. Alqahtani verfasserin aut Muntaser E. Ibrahim verfasserin aut Adil H. H. Bashir verfasserin aut Sari T. S. Alhoufie verfasserin aut Gamal O. Elhassan verfasserin aut Christian C. Wales verfasserin aut Laurent H. Schwartz verfasserin aut Heyam S. Ali verfasserin aut Ahmed Ahmed verfasserin aut Patrick F. Forde verfasserin aut Jesus Devesa verfasserin aut Rosa A. Cardone verfasserin aut Stefano Fais verfasserin aut Salvador Harguindey verfasserin aut Stephan J. Reshkin verfasserin aut In Metabolites MDPI AG, 2012 10(2020), 7, p 285 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:10 year:2020 number:7, p 285 https://doi.org/10.3390/metabo10070285 kostenfrei https://doaj.org/article/97aae85c7d4744afaf11a9c2481043d5 kostenfrei https://www.mdpi.com/2218-1989/10/7/285 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 7, p 285
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allfieldsSound	10.3390/metabo10070285 doi (DE-627)DOAJ059730838 (DE-599)DOAJ97aae85c7d4744afaf11a9c2481043d5 DE-627 ger DE-627 rakwb eng QR1-502 Khalid O. Alfarouk verfasserin aut The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. However, cytoplasmic glucose utilization can also occur in cancer through the PPP. This pathway contributes to cancer cells by operating in many different ways: (i) as a defense mechanism via the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to prevent apoptosis, (ii) as a provision for the maintenance of energy by intermediate glycolysis, (iii) by increasing genomic material to the cellular pool of nucleic acid bases, (iv) by promoting survival through increasing glycolysis, and so increasing acid production, and (v) by inducing cellular proliferation by the synthesis of nucleic acid, fatty acid, and amino acid. Each step of the PPP can be upregulated in some types of cancer but not in others. An interesting aspect of this metabolic pathway is the shared regulation of the glycolytic and PPP pathways by intracellular pH (pHi). Indeed, as with glycolysis, the optimum activity of the enzymes driving the PPP occurs at an alkaline pHi, which is compatible with the cytoplasmic pH of cancer cells. Here, we outline each step of the PPP and discuss its possible correlation with cancer. cancer metabolism enzyme pH redox Microbiology Samrein B. M. Ahmed verfasserin aut Robert L. Elliott verfasserin aut Amanda Benoit verfasserin aut Saad S. Alqahtani verfasserin aut Muntaser E. Ibrahim verfasserin aut Adil H. H. Bashir verfasserin aut Sari T. S. Alhoufie verfasserin aut Gamal O. Elhassan verfasserin aut Christian C. Wales verfasserin aut Laurent H. Schwartz verfasserin aut Heyam S. Ali verfasserin aut Ahmed Ahmed verfasserin aut Patrick F. Forde verfasserin aut Jesus Devesa verfasserin aut Rosa A. Cardone verfasserin aut Stefano Fais verfasserin aut Salvador Harguindey verfasserin aut Stephan J. Reshkin verfasserin aut In Metabolites MDPI AG, 2012 10(2020), 7, p 285 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:10 year:2020 number:7, p 285 https://doi.org/10.3390/metabo10070285 kostenfrei https://doaj.org/article/97aae85c7d4744afaf11a9c2481043d5 kostenfrei https://www.mdpi.com/2218-1989/10/7/285 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 7, p 285
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author	Khalid O. Alfarouk
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title_auth	The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH
abstract	The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. However, cytoplasmic glucose utilization can also occur in cancer through the PPP. This pathway contributes to cancer cells by operating in many different ways: (i) as a defense mechanism via the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to prevent apoptosis, (ii) as a provision for the maintenance of energy by intermediate glycolysis, (iii) by increasing genomic material to the cellular pool of nucleic acid bases, (iv) by promoting survival through increasing glycolysis, and so increasing acid production, and (v) by inducing cellular proliferation by the synthesis of nucleic acid, fatty acid, and amino acid. Each step of the PPP can be upregulated in some types of cancer but not in others. An interesting aspect of this metabolic pathway is the shared regulation of the glycolytic and PPP pathways by intracellular pH (pHi). Indeed, as with glycolysis, the optimum activity of the enzymes driving the PPP occurs at an alkaline pHi, which is compatible with the cytoplasmic pH of cancer cells. Here, we outline each step of the PPP and discuss its possible correlation with cancer.
abstractGer	The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. However, cytoplasmic glucose utilization can also occur in cancer through the PPP. This pathway contributes to cancer cells by operating in many different ways: (i) as a defense mechanism via the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to prevent apoptosis, (ii) as a provision for the maintenance of energy by intermediate glycolysis, (iii) by increasing genomic material to the cellular pool of nucleic acid bases, (iv) by promoting survival through increasing glycolysis, and so increasing acid production, and (v) by inducing cellular proliferation by the synthesis of nucleic acid, fatty acid, and amino acid. Each step of the PPP can be upregulated in some types of cancer but not in others. An interesting aspect of this metabolic pathway is the shared regulation of the glycolytic and PPP pathways by intracellular pH (pHi). Indeed, as with glycolysis, the optimum activity of the enzymes driving the PPP occurs at an alkaline pHi, which is compatible with the cytoplasmic pH of cancer cells. Here, we outline each step of the PPP and discuss its possible correlation with cancer.
abstract_unstemmed	The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. However, cytoplasmic glucose utilization can also occur in cancer through the PPP. This pathway contributes to cancer cells by operating in many different ways: (i) as a defense mechanism via the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to prevent apoptosis, (ii) as a provision for the maintenance of energy by intermediate glycolysis, (iii) by increasing genomic material to the cellular pool of nucleic acid bases, (iv) by promoting survival through increasing glycolysis, and so increasing acid production, and (v) by inducing cellular proliferation by the synthesis of nucleic acid, fatty acid, and amino acid. Each step of the PPP can be upregulated in some types of cancer but not in others. An interesting aspect of this metabolic pathway is the shared regulation of the glycolytic and PPP pathways by intracellular pH (pHi). Indeed, as with glycolysis, the optimum activity of the enzymes driving the PPP occurs at an alkaline pHi, which is compatible with the cytoplasmic pH of cancer cells. Here, we outline each step of the PPP and discuss its possible correlation with cancer.
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url	https://doi.org/10.3390/metabo10070285 https://doaj.org/article/97aae85c7d4744afaf11a9c2481043d5 https://www.mdpi.com/2218-1989/10/7/285 https://doaj.org/toc/2218-1989
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author2	Samrein B. M. Ahmed Robert L. Elliott Amanda Benoit Saad S. Alqahtani Muntaser E. Ibrahim Adil H. H. Bashir Sari T. S. Alhoufie Gamal O. Elhassan Christian C. Wales Laurent H. Schwartz Heyam S. Ali Ahmed Ahmed Patrick F. Forde Jesus Devesa Rosa A. Cardone Stefano Fais Salvador Harguindey Stephan J. Reshkin
author2Str	Samrein B. M. Ahmed Robert L. Elliott Amanda Benoit Saad S. Alqahtani Muntaser E. Ibrahim Adil H. H. Bashir Sari T. S. Alhoufie Gamal O. Elhassan Christian C. Wales Laurent H. Schwartz Heyam S. Ali Ahmed Ahmed Patrick F. Forde Jesus Devesa Rosa A. Cardone Stefano Fais Salvador Harguindey Stephan J. Reshkin
ppnlink	718627164
callnumber-subject	QR - Microbiology
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doi_str	10.3390/metabo10070285
callnumber-a	QR1-502
up_date	2024-07-04T00:41:01.220Z
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Alfarouk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the presence of oxygen; this is known as the “Warburg Effect”. However, cytoplasmic glucose utilization can also occur in cancer through the PPP. This pathway contributes to cancer cells by operating in many different ways: (i) as a defense mechanism via the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) to prevent apoptosis, (ii) as a provision for the maintenance of energy by intermediate glycolysis, (iii) by increasing genomic material to the cellular pool of nucleic acid bases, (iv) by promoting survival through increasing glycolysis, and so increasing acid production, and (v) by inducing cellular proliferation by the synthesis of nucleic acid, fatty acid, and amino acid. Each step of the PPP can be upregulated in some types of cancer but not in others. 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