Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection

The dopamine (DA) D3 receptor (D3R) plays a pivotal role in the control of several functions, including motor activity, rewarding and motivating behavior and several aspects of cognitive functions. Recently, it has been reported that the D3R is also involved in the regulation of neuronal development...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Federica Bono [verfasserIn] Veronica Mutti [verfasserIn] Chiara Fiorentini [verfasserIn] Cristina Missale [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	dopamine dopamine D3 receptor nicotinic acetylcholine receptor heteromerization neuroplasticity neuroprotection

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 10(2020), 7, p 1016
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:7, p 1016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom10071016

Katalog-ID:	DOAJ059733454

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allfields	10.3390/biom10071016 doi (DE-627)DOAJ059733454 (DE-599)DOAJ7bee0c82bfe84fc18a07acb1ad1d956a DE-627 ger DE-627 rakwb eng QR1-502 Federica Bono verfasserin aut Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The dopamine (DA) D3 receptor (D3R) plays a pivotal role in the control of several functions, including motor activity, rewarding and motivating behavior and several aspects of cognitive functions. Recently, it has been reported that the D3R is also involved in the regulation of neuronal development, in promoting structural plasticity and in triggering key intracellular events with neuroprotective potential. A new role for D3R-dependent neurotransmission has thus been proposed both in preserving DA neuron homeostasis in physiological conditions and in preventing pathological alterations that may lead to neurodegeneration. Interestingly, there is evidence that nicotinic acetylcholine receptors (nAChR) located on DA neurons also provide neurotrophic support to DA neurons, an effect requiring functional D3R and suggesting the existence of a positive cross-talk between these receptor systems. Increasing evidence suggests that, as with the majority of G protein-coupled receptors (GPCR), the D3R directly interacts with other receptors to form new receptor heteromers with unique functional and pharmacological properties. Among them, we recently identified a receptor heteromer containing the nAChR and the D3R as the molecular effector of nicotine-mediated neurotrophic effects. This review summarizes the functional and pharmacological characteristics of D3R, including the capability to form active heteromers as pharmacological targets for specific neurodegenerative disorders. In particular, the molecular and functional features of the D3R-nAChR heteromer will be especially discussed since it may represent a possible key etiologic effector for DA-related pathologies, such as Parkinson’s disease (PD), and a target for drug design. dopamine dopamine D3 receptor nicotinic acetylcholine receptor heteromerization neuroplasticity neuroprotection Microbiology Veronica Mutti verfasserin aut Chiara Fiorentini verfasserin aut Cristina Missale verfasserin aut In Biomolecules MDPI AG, 2013 10(2020), 7, p 1016 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:10 year:2020 number:7, p 1016 https://doi.org/10.3390/biom10071016 kostenfrei https://doaj.org/article/7bee0c82bfe84fc18a07acb1ad1d956a kostenfrei https://www.mdpi.com/2218-273X/10/7/1016 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 7, p 1016
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language	English
source	In Biomolecules 10(2020), 7, p 1016 volume:10 year:2020 number:7, p 1016
sourceStr	In Biomolecules 10(2020), 7, p 1016 volume:10 year:2020 number:7, p 1016
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topic_facet	dopamine dopamine D3 receptor nicotinic acetylcholine receptor heteromerization neuroplasticity neuroprotection Microbiology
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authorswithroles_txt_mv	Federica Bono @@aut@@ Veronica Mutti @@aut@@ Chiara Fiorentini @@aut@@ Cristina Missale @@aut@@
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callnumber-first	Q - Science
author	Federica Bono
spellingShingle	Federica Bono misc QR1-502 misc dopamine misc dopamine D3 receptor misc nicotinic acetylcholine receptor misc heteromerization misc neuroplasticity misc neuroprotection misc Microbiology Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection
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topic_title	QR1-502 Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection dopamine dopamine D3 receptor nicotinic acetylcholine receptor heteromerization neuroplasticity neuroprotection
topic	misc QR1-502 misc dopamine misc dopamine D3 receptor misc nicotinic acetylcholine receptor misc heteromerization misc neuroplasticity misc neuroprotection misc Microbiology
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title	Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection
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title_sort	dopamine d3 receptor heteromerization: implications for neuroplasticity and neuroprotection
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title_auth	Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection
abstract	The dopamine (DA) D3 receptor (D3R) plays a pivotal role in the control of several functions, including motor activity, rewarding and motivating behavior and several aspects of cognitive functions. Recently, it has been reported that the D3R is also involved in the regulation of neuronal development, in promoting structural plasticity and in triggering key intracellular events with neuroprotective potential. A new role for D3R-dependent neurotransmission has thus been proposed both in preserving DA neuron homeostasis in physiological conditions and in preventing pathological alterations that may lead to neurodegeneration. Interestingly, there is evidence that nicotinic acetylcholine receptors (nAChR) located on DA neurons also provide neurotrophic support to DA neurons, an effect requiring functional D3R and suggesting the existence of a positive cross-talk between these receptor systems. Increasing evidence suggests that, as with the majority of G protein-coupled receptors (GPCR), the D3R directly interacts with other receptors to form new receptor heteromers with unique functional and pharmacological properties. Among them, we recently identified a receptor heteromer containing the nAChR and the D3R as the molecular effector of nicotine-mediated neurotrophic effects. This review summarizes the functional and pharmacological characteristics of D3R, including the capability to form active heteromers as pharmacological targets for specific neurodegenerative disorders. In particular, the molecular and functional features of the D3R-nAChR heteromer will be especially discussed since it may represent a possible key etiologic effector for DA-related pathologies, such as Parkinson’s disease (PD), and a target for drug design.
abstractGer	The dopamine (DA) D3 receptor (D3R) plays a pivotal role in the control of several functions, including motor activity, rewarding and motivating behavior and several aspects of cognitive functions. Recently, it has been reported that the D3R is also involved in the regulation of neuronal development, in promoting structural plasticity and in triggering key intracellular events with neuroprotective potential. A new role for D3R-dependent neurotransmission has thus been proposed both in preserving DA neuron homeostasis in physiological conditions and in preventing pathological alterations that may lead to neurodegeneration. Interestingly, there is evidence that nicotinic acetylcholine receptors (nAChR) located on DA neurons also provide neurotrophic support to DA neurons, an effect requiring functional D3R and suggesting the existence of a positive cross-talk between these receptor systems. Increasing evidence suggests that, as with the majority of G protein-coupled receptors (GPCR), the D3R directly interacts with other receptors to form new receptor heteromers with unique functional and pharmacological properties. Among them, we recently identified a receptor heteromer containing the nAChR and the D3R as the molecular effector of nicotine-mediated neurotrophic effects. This review summarizes the functional and pharmacological characteristics of D3R, including the capability to form active heteromers as pharmacological targets for specific neurodegenerative disorders. In particular, the molecular and functional features of the D3R-nAChR heteromer will be especially discussed since it may represent a possible key etiologic effector for DA-related pathologies, such as Parkinson’s disease (PD), and a target for drug design.
abstract_unstemmed	The dopamine (DA) D3 receptor (D3R) plays a pivotal role in the control of several functions, including motor activity, rewarding and motivating behavior and several aspects of cognitive functions. Recently, it has been reported that the D3R is also involved in the regulation of neuronal development, in promoting structural plasticity and in triggering key intracellular events with neuroprotective potential. A new role for D3R-dependent neurotransmission has thus been proposed both in preserving DA neuron homeostasis in physiological conditions and in preventing pathological alterations that may lead to neurodegeneration. Interestingly, there is evidence that nicotinic acetylcholine receptors (nAChR) located on DA neurons also provide neurotrophic support to DA neurons, an effect requiring functional D3R and suggesting the existence of a positive cross-talk between these receptor systems. Increasing evidence suggests that, as with the majority of G protein-coupled receptors (GPCR), the D3R directly interacts with other receptors to form new receptor heteromers with unique functional and pharmacological properties. Among them, we recently identified a receptor heteromer containing the nAChR and the D3R as the molecular effector of nicotine-mediated neurotrophic effects. This review summarizes the functional and pharmacological characteristics of D3R, including the capability to form active heteromers as pharmacological targets for specific neurodegenerative disorders. In particular, the molecular and functional features of the D3R-nAChR heteromer will be especially discussed since it may represent a possible key etiologic effector for DA-related pathologies, such as Parkinson’s disease (PD), and a target for drug design.
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title_short	Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection
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Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection

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