Antioxidant Therapies for Neuroprotection—A Review
Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the...
Ausführliche Beschreibung
Autor*in: |
Raluca Ioana Teleanu [verfasserIn] Cristina Chircov [verfasserIn] Alexandru Mihai Grumezescu [verfasserIn] Adrian Volceanov [verfasserIn] Daniel Mihai Teleanu [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2019 |
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Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 8(2019), 10, p 1659 |
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Übergeordnetes Werk: |
volume:8 ; year:2019 ; number:10, p 1659 |
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DOI / URN: |
10.3390/jcm8101659 |
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Katalog-ID: |
DOAJ059851821 |
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10.3390/jcm8101659 doi (DE-627)DOAJ059851821 (DE-599)DOAJ84b2e8c200424bfd9c4a9b51ba6f39dd DE-627 ger DE-627 rakwb eng Raluca Ioana Teleanu verfasserin aut Antioxidant Therapies for Neuroprotection—A Review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection. antioxidant therapy reactive nitrogen species reactive oxygen species neuroprotection Medicine R Cristina Chircov verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Adrian Volceanov verfasserin aut Daniel Mihai Teleanu verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 10, p 1659 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:10, p 1659 https://doi.org/10.3390/jcm8101659 kostenfrei https://doaj.org/article/84b2e8c200424bfd9c4a9b51ba6f39dd kostenfrei https://www.mdpi.com/2077-0383/8/10/1659 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 10, p 1659 |
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10.3390/jcm8101659 doi (DE-627)DOAJ059851821 (DE-599)DOAJ84b2e8c200424bfd9c4a9b51ba6f39dd DE-627 ger DE-627 rakwb eng Raluca Ioana Teleanu verfasserin aut Antioxidant Therapies for Neuroprotection—A Review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection. antioxidant therapy reactive nitrogen species reactive oxygen species neuroprotection Medicine R Cristina Chircov verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Adrian Volceanov verfasserin aut Daniel Mihai Teleanu verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 10, p 1659 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:10, p 1659 https://doi.org/10.3390/jcm8101659 kostenfrei https://doaj.org/article/84b2e8c200424bfd9c4a9b51ba6f39dd kostenfrei https://www.mdpi.com/2077-0383/8/10/1659 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 10, p 1659 |
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10.3390/jcm8101659 doi (DE-627)DOAJ059851821 (DE-599)DOAJ84b2e8c200424bfd9c4a9b51ba6f39dd DE-627 ger DE-627 rakwb eng Raluca Ioana Teleanu verfasserin aut Antioxidant Therapies for Neuroprotection—A Review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection. antioxidant therapy reactive nitrogen species reactive oxygen species neuroprotection Medicine R Cristina Chircov verfasserin aut Alexandru Mihai Grumezescu verfasserin aut Adrian Volceanov verfasserin aut Daniel Mihai Teleanu verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 10, p 1659 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:10, p 1659 https://doi.org/10.3390/jcm8101659 kostenfrei https://doaj.org/article/84b2e8c200424bfd9c4a9b51ba6f39dd kostenfrei https://www.mdpi.com/2077-0383/8/10/1659 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 10, p 1659 |
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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection. |
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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection. |
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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection. |
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|
score |
7.398508 |