Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice.
Autor*in: |
Yawei Wang [verfasserIn] Binlin Tang [verfasserIn] Lei Long [verfasserIn] Peng Luo [verfasserIn] Wei Xiang [verfasserIn] Xueru Li [verfasserIn] Huilan Wang [verfasserIn] Qingzhi Jiang [verfasserIn] Xu Tan [verfasserIn] Shenglin Luo [verfasserIn] Huijuan Li [verfasserIn] Ziwen Wang [verfasserIn] Zelin Chen [verfasserIn] Yu Leng [verfasserIn] Zhongyong Jiang [verfasserIn] Yang Wang [verfasserIn] Le Ma [verfasserIn] Rui Wang [verfasserIn] Chunyu Zeng [verfasserIn] Zujuan Liu [verfasserIn] Yu Wang [verfasserIn] Hongming Miao [verfasserIn] Chunmeng Shi [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 16 |
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Übergeordnetes Werk: |
volume:12 ; year:2021 ; number:1 ; pages:16 |
Links: |
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DOI / URN: |
10.1038/s41467-020-20315-9 |
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Katalog-ID: |
DOAJ06003193X |
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10.1038/s41467-020-20315-9 doi (DE-627)DOAJ06003193X (DE-599)DOAJ6984acd91fab463ba6643d7cdc1514c5 DE-627 ger DE-627 rakwb eng Yawei Wang verfasserin aut Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. Science Q Binlin Tang verfasserin aut Lei Long verfasserin aut Peng Luo verfasserin aut Wei Xiang verfasserin aut Xueru Li verfasserin aut Huilan Wang verfasserin aut Qingzhi Jiang verfasserin aut Xu Tan verfasserin aut Shenglin Luo verfasserin aut Huijuan Li verfasserin aut Ziwen Wang verfasserin aut Zelin Chen verfasserin aut Yu Leng verfasserin aut Zhongyong Jiang verfasserin aut Yang Wang verfasserin aut Le Ma verfasserin aut Rui Wang verfasserin aut Chunyu Zeng verfasserin aut Zujuan Liu verfasserin aut Yu Wang verfasserin aut Hongming Miao verfasserin aut Chunmeng Shi verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:16 https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/article/6984acd91fab463ba6643d7cdc1514c5 kostenfrei https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 16 |
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10.1038/s41467-020-20315-9 doi (DE-627)DOAJ06003193X (DE-599)DOAJ6984acd91fab463ba6643d7cdc1514c5 DE-627 ger DE-627 rakwb eng Yawei Wang verfasserin aut Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. Science Q Binlin Tang verfasserin aut Lei Long verfasserin aut Peng Luo verfasserin aut Wei Xiang verfasserin aut Xueru Li verfasserin aut Huilan Wang verfasserin aut Qingzhi Jiang verfasserin aut Xu Tan verfasserin aut Shenglin Luo verfasserin aut Huijuan Li verfasserin aut Ziwen Wang verfasserin aut Zelin Chen verfasserin aut Yu Leng verfasserin aut Zhongyong Jiang verfasserin aut Yang Wang verfasserin aut Le Ma verfasserin aut Rui Wang verfasserin aut Chunyu Zeng verfasserin aut Zujuan Liu verfasserin aut Yu Wang verfasserin aut Hongming Miao verfasserin aut Chunmeng Shi verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:16 https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/article/6984acd91fab463ba6643d7cdc1514c5 kostenfrei https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 16 |
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10.1038/s41467-020-20315-9 doi (DE-627)DOAJ06003193X (DE-599)DOAJ6984acd91fab463ba6643d7cdc1514c5 DE-627 ger DE-627 rakwb eng Yawei Wang verfasserin aut Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. Science Q Binlin Tang verfasserin aut Lei Long verfasserin aut Peng Luo verfasserin aut Wei Xiang verfasserin aut Xueru Li verfasserin aut Huilan Wang verfasserin aut Qingzhi Jiang verfasserin aut Xu Tan verfasserin aut Shenglin Luo verfasserin aut Huijuan Li verfasserin aut Ziwen Wang verfasserin aut Zelin Chen verfasserin aut Yu Leng verfasserin aut Zhongyong Jiang verfasserin aut Yang Wang verfasserin aut Le Ma verfasserin aut Rui Wang verfasserin aut Chunyu Zeng verfasserin aut Zujuan Liu verfasserin aut Yu Wang verfasserin aut Hongming Miao verfasserin aut Chunmeng Shi verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:16 https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/article/6984acd91fab463ba6643d7cdc1514c5 kostenfrei https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 16 |
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10.1038/s41467-020-20315-9 doi (DE-627)DOAJ06003193X (DE-599)DOAJ6984acd91fab463ba6643d7cdc1514c5 DE-627 ger DE-627 rakwb eng Yawei Wang verfasserin aut Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. Science Q Binlin Tang verfasserin aut Lei Long verfasserin aut Peng Luo verfasserin aut Wei Xiang verfasserin aut Xueru Li verfasserin aut Huilan Wang verfasserin aut Qingzhi Jiang verfasserin aut Xu Tan verfasserin aut Shenglin Luo verfasserin aut Huijuan Li verfasserin aut Ziwen Wang verfasserin aut Zelin Chen verfasserin aut Yu Leng verfasserin aut Zhongyong Jiang verfasserin aut Yang Wang verfasserin aut Le Ma verfasserin aut Rui Wang verfasserin aut Chunyu Zeng verfasserin aut Zujuan Liu verfasserin aut Yu Wang verfasserin aut Hongming Miao verfasserin aut Chunmeng Shi verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:16 https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/article/6984acd91fab463ba6643d7cdc1514c5 kostenfrei https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 16 |
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10.1038/s41467-020-20315-9 doi (DE-627)DOAJ06003193X (DE-599)DOAJ6984acd91fab463ba6643d7cdc1514c5 DE-627 ger DE-627 rakwb eng Yawei Wang verfasserin aut Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. Science Q Binlin Tang verfasserin aut Lei Long verfasserin aut Peng Luo verfasserin aut Wei Xiang verfasserin aut Xueru Li verfasserin aut Huilan Wang verfasserin aut Qingzhi Jiang verfasserin aut Xu Tan verfasserin aut Shenglin Luo verfasserin aut Huijuan Li verfasserin aut Ziwen Wang verfasserin aut Zelin Chen verfasserin aut Yu Leng verfasserin aut Zhongyong Jiang verfasserin aut Yang Wang verfasserin aut Le Ma verfasserin aut Rui Wang verfasserin aut Chunyu Zeng verfasserin aut Zujuan Liu verfasserin aut Yu Wang verfasserin aut Hongming Miao verfasserin aut Chunmeng Shi verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:16 https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/article/6984acd91fab463ba6643d7cdc1514c5 kostenfrei https://doi.org/10.1038/s41467-020-20315-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 16 |
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Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages |
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Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. |
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Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. |
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Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice. |
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Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages |
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