Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1

The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome prolifer...
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Gespeichert in:

Autor*in:	Maricela Rodriguez-Cruz [verfasserIn] Armando R. Tovar [verfasserIn] Berenice Palacios-GonzaÌlez [verfasserIn] Martha del Prado [verfasserIn] Nimbe Torres [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2006

Schlagwörter:	sterol-regulatory element binding protein 1 peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptor γ coactivator 1

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 47(2006), 3, Seite 553-560
Übergeordnetes Werk:	volume:47 ; year:2006 ; number:3 ; pages:553-560

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M500407-JLR200

Katalog-ID:	DOAJ060061030

Internformat


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allfields	10.1194/jlr.M500407-JLR200 doi (DE-627)DOAJ060061030 (DE-599)DOAJ979a2c2e7a9c4b9083dc28faa4956a6a DE-627 ger DE-627 rakwb eng QD415-436 Maricela Rodriguez-Cruz verfasserin aut Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet. sterol-regulatory element binding protein 1 peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptor γ coactivator 1 Biochemistry Armando R. Tovar verfasserin aut Berenice Palacios-GonzaÌlez verfasserin aut Martha del Prado verfasserin aut Nimbe Torres verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 3, Seite 553-560 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:3 pages:553-560 https://doi.org/10.1194/jlr.M500407-JLR200 kostenfrei https://doaj.org/article/979a2c2e7a9c4b9083dc28faa4956a6a kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520336099 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 3 553-560
spelling	10.1194/jlr.M500407-JLR200 doi (DE-627)DOAJ060061030 (DE-599)DOAJ979a2c2e7a9c4b9083dc28faa4956a6a DE-627 ger DE-627 rakwb eng QD415-436 Maricela Rodriguez-Cruz verfasserin aut Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet. sterol-regulatory element binding protein 1 peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptor γ coactivator 1 Biochemistry Armando R. Tovar verfasserin aut Berenice Palacios-GonzaÌlez verfasserin aut Martha del Prado verfasserin aut Nimbe Torres verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 3, Seite 553-560 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:3 pages:553-560 https://doi.org/10.1194/jlr.M500407-JLR200 kostenfrei https://doaj.org/article/979a2c2e7a9c4b9083dc28faa4956a6a kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520336099 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 3 553-560
allfields_unstemmed	10.1194/jlr.M500407-JLR200 doi (DE-627)DOAJ060061030 (DE-599)DOAJ979a2c2e7a9c4b9083dc28faa4956a6a DE-627 ger DE-627 rakwb eng QD415-436 Maricela Rodriguez-Cruz verfasserin aut Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet. sterol-regulatory element binding protein 1 peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptor γ coactivator 1 Biochemistry Armando R. Tovar verfasserin aut Berenice Palacios-GonzaÌlez verfasserin aut Martha del Prado verfasserin aut Nimbe Torres verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 3, Seite 553-560 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:3 pages:553-560 https://doi.org/10.1194/jlr.M500407-JLR200 kostenfrei https://doaj.org/article/979a2c2e7a9c4b9083dc28faa4956a6a kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520336099 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 3 553-560
allfieldsGer	10.1194/jlr.M500407-JLR200 doi (DE-627)DOAJ060061030 (DE-599)DOAJ979a2c2e7a9c4b9083dc28faa4956a6a DE-627 ger DE-627 rakwb eng QD415-436 Maricela Rodriguez-Cruz verfasserin aut Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet. sterol-regulatory element binding protein 1 peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptor γ coactivator 1 Biochemistry Armando R. Tovar verfasserin aut Berenice Palacios-GonzaÌlez verfasserin aut Martha del Prado verfasserin aut Nimbe Torres verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 3, Seite 553-560 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:3 pages:553-560 https://doi.org/10.1194/jlr.M500407-JLR200 kostenfrei https://doaj.org/article/979a2c2e7a9c4b9083dc28faa4956a6a kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520336099 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 3 553-560
allfieldsSound	10.1194/jlr.M500407-JLR200 doi (DE-627)DOAJ060061030 (DE-599)DOAJ979a2c2e7a9c4b9083dc28faa4956a6a DE-627 ger DE-627 rakwb eng QD415-436 Maricela Rodriguez-Cruz verfasserin aut Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet. sterol-regulatory element binding protein 1 peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptor γ coactivator 1 Biochemistry Armando R. Tovar verfasserin aut Berenice Palacios-GonzaÌlez verfasserin aut Martha del Prado verfasserin aut Nimbe Torres verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 3, Seite 553-560 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:3 pages:553-560 https://doi.org/10.1194/jlr.M500407-JLR200 kostenfrei https://doaj.org/article/979a2c2e7a9c4b9083dc28faa4956a6a kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520336099 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 3 553-560
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callnumber-first	Q - Science
author	Maricela Rodriguez-Cruz
spellingShingle	Maricela Rodriguez-Cruz misc QD415-436 misc sterol-regulatory element binding protein 1 misc peroxisome proliferator-activated receptor α misc peroxisome proliferator-activated receptor γ coactivator 1 misc Biochemistry Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1
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topic_title	QD415-436 Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1 sterol-regulatory element binding protein 1 peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptor γ coactivator 1
topic	misc QD415-436 misc sterol-regulatory element binding protein 1 misc peroxisome proliferator-activated receptor α misc peroxisome proliferator-activated receptor γ coactivator 1 misc Biochemistry
topic_unstemmed	misc QD415-436 misc sterol-regulatory element binding protein 1 misc peroxisome proliferator-activated receptor α misc peroxisome proliferator-activated receptor γ coactivator 1 misc Biochemistry
topic_browse	misc QD415-436 misc sterol-regulatory element binding protein 1 misc peroxisome proliferator-activated receptor α misc peroxisome proliferator-activated receptor γ coactivator 1 misc Biochemistry
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title	Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1
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title_full	Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1
author_sort	Maricela Rodriguez-Cruz
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author_browse	Maricela Rodriguez-Cruz Armando R. Tovar Berenice Palacios-GonzaÌlez Martha del Prado Nimbe Torres
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title_sort	synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of δ5 and δ6 desaturases, srebp-1, pparα, and pgc-1
callnumber	QD415-436
title_auth	Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1
abstract	The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet.
abstractGer	The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet.
abstract_unstemmed	The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of Δ5 and Δ6 desaturases (Δ5D and Δ6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor α (PPARα) and the coactivator peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), and whether these desaturases are regulated by the lipid concentration in the diet. The results showed that on day 12 of lactation, ∼35% of the linoleic acid in the diet, which is the precursor of PUFAs, is transferred to the mammary gland. There was expression of Δ5D and Δ6D in mammary gland, and it was regulated by the corn oil content in the diet. The higher the corn oil content in the diet, the lower the expression of both desaturases. Induction of Δ5D and Δ6D was associated positively with similar changes in SREBP-1 and PGC-1β. Expression of PPARα was barely detected and was not affected by the corn oil content in the diet, whereas PGC-1β expression increased as the corn oil in the diet increased. These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet.
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title_short	Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1
url	https://doi.org/10.1194/jlr.M500407-JLR200 https://doaj.org/article/979a2c2e7a9c4b9083dc28faa4956a6a http://www.sciencedirect.com/science/article/pii/S0022227520336099 https://doaj.org/toc/0022-2275
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author2	Armando R. Tovar Berenice Palacios-GonzaÌlez Martha del Prado Nimbe Torres
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up_date	2024-07-04T01:54:05.717Z
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Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1

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