Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers

Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with li...
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Autor*in:	Lin Yang [verfasserIn] Junjun Liu [verfasserIn] Junhong Deng [verfasserIn] Zhifeng Huang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	(2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity

Übergeordnetes Werk:	In: InfoMat - Wiley, 2019, 2(2020), 6, Seite 1216-1224
Übergeordnetes Werk:	volume:2 ; year:2020 ; number:6 ; pages:1216-1224

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/inf2.12091

Katalog-ID:	DOAJ060225793

Internformat


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245	1	0	\|a Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
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520			\|a Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals.
650		4	\|a (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt
650		4	\|a chiral nanoparticles
650		4	\|a circular dichroism
650		4	\|a glancing angle deposition
650		4	\|a optical activity
653		0	\|a Materials of engineering and construction. Mechanics of materials
653		0	\|a Information technology
700	0		\|a Junjun Liu \|e verfasserin \|4 aut
700	0		\|a Junhong Deng \|e verfasserin \|4 aut
700	0		\|a Zhifeng Huang \|e verfasserin \|4 aut
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912			\|a GBV_ILN_39
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912			\|a GBV_ILN_65
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912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
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912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
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912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2118
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912			\|a GBV_ILN_2143
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912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
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matchkey_str	article:25673165:2020----::hrlaoatcenueapiiainnpiaatvtoml
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publishDate	2020
allfields	10.1002/inf2.12091 doi (DE-627)DOAJ060225793 (DE-599)DOAJ1c9bc90dbec8499b99c60d313623f7af DE-627 ger DE-627 rakwb eng TA401-492 T58.5-58.64 Lin Yang verfasserin aut Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals. (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity Materials of engineering and construction. Mechanics of materials Information technology Junjun Liu verfasserin aut Junhong Deng verfasserin aut Zhifeng Huang verfasserin aut In InfoMat Wiley, 2019 2(2020), 6, Seite 1216-1224 (DE-627)895684195 (DE-600)2902931-4 25673165 nnns volume:2 year:2020 number:6 pages:1216-1224 https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/article/1c9bc90dbec8499b99c60d313623f7af kostenfrei https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/toc/2567-3165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2020 6 1216-1224
spelling	10.1002/inf2.12091 doi (DE-627)DOAJ060225793 (DE-599)DOAJ1c9bc90dbec8499b99c60d313623f7af DE-627 ger DE-627 rakwb eng TA401-492 T58.5-58.64 Lin Yang verfasserin aut Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals. (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity Materials of engineering and construction. Mechanics of materials Information technology Junjun Liu verfasserin aut Junhong Deng verfasserin aut Zhifeng Huang verfasserin aut In InfoMat Wiley, 2019 2(2020), 6, Seite 1216-1224 (DE-627)895684195 (DE-600)2902931-4 25673165 nnns volume:2 year:2020 number:6 pages:1216-1224 https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/article/1c9bc90dbec8499b99c60d313623f7af kostenfrei https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/toc/2567-3165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2020 6 1216-1224
allfields_unstemmed	10.1002/inf2.12091 doi (DE-627)DOAJ060225793 (DE-599)DOAJ1c9bc90dbec8499b99c60d313623f7af DE-627 ger DE-627 rakwb eng TA401-492 T58.5-58.64 Lin Yang verfasserin aut Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals. (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity Materials of engineering and construction. Mechanics of materials Information technology Junjun Liu verfasserin aut Junhong Deng verfasserin aut Zhifeng Huang verfasserin aut In InfoMat Wiley, 2019 2(2020), 6, Seite 1216-1224 (DE-627)895684195 (DE-600)2902931-4 25673165 nnns volume:2 year:2020 number:6 pages:1216-1224 https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/article/1c9bc90dbec8499b99c60d313623f7af kostenfrei https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/toc/2567-3165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2020 6 1216-1224
allfieldsGer	10.1002/inf2.12091 doi (DE-627)DOAJ060225793 (DE-599)DOAJ1c9bc90dbec8499b99c60d313623f7af DE-627 ger DE-627 rakwb eng TA401-492 T58.5-58.64 Lin Yang verfasserin aut Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals. (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity Materials of engineering and construction. Mechanics of materials Information technology Junjun Liu verfasserin aut Junhong Deng verfasserin aut Zhifeng Huang verfasserin aut In InfoMat Wiley, 2019 2(2020), 6, Seite 1216-1224 (DE-627)895684195 (DE-600)2902931-4 25673165 nnns volume:2 year:2020 number:6 pages:1216-1224 https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/article/1c9bc90dbec8499b99c60d313623f7af kostenfrei https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/toc/2567-3165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2020 6 1216-1224
allfieldsSound	10.1002/inf2.12091 doi (DE-627)DOAJ060225793 (DE-599)DOAJ1c9bc90dbec8499b99c60d313623f7af DE-627 ger DE-627 rakwb eng TA401-492 T58.5-58.64 Lin Yang verfasserin aut Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals. (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity Materials of engineering and construction. Mechanics of materials Information technology Junjun Liu verfasserin aut Junhong Deng verfasserin aut Zhifeng Huang verfasserin aut In InfoMat Wiley, 2019 2(2020), 6, Seite 1216-1224 (DE-627)895684195 (DE-600)2902931-4 25673165 nnns volume:2 year:2020 number:6 pages:1216-1224 https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/article/1c9bc90dbec8499b99c60d313623f7af kostenfrei https://doi.org/10.1002/inf2.12091 kostenfrei https://doaj.org/toc/2567-3165 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2020 6 1216-1224
language	English
source	In InfoMat 2(2020), 6, Seite 1216-1224 volume:2 year:2020 number:6 pages:1216-1224
sourceStr	In InfoMat 2(2020), 6, Seite 1216-1224 volume:2 year:2020 number:6 pages:1216-1224
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	(2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity Materials of engineering and construction. Mechanics of materials Information technology
isfreeaccess_bool	true
container_title	InfoMat
authorswithroles_txt_mv	Lin Yang @@aut@@ Junjun Liu @@aut@@ Junhong Deng @@aut@@ Zhifeng Huang @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	895684195
id	DOAJ060225793
language_de	englisch
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callnumber-first	T - Technology
author	Lin Yang
spellingShingle	Lin Yang misc TA401-492 misc T58.5-58.64 misc (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt misc chiral nanoparticles misc circular dichroism misc glancing angle deposition misc optical activity misc Materials of engineering and construction. Mechanics of materials misc Information technology Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
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topic_title	TA401-492 T58.5-58.64 Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity
topic	misc TA401-492 misc T58.5-58.64 misc (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt misc chiral nanoparticles misc circular dichroism misc glancing angle deposition misc optical activity misc Materials of engineering and construction. Mechanics of materials misc Information technology
topic_unstemmed	misc TA401-492 misc T58.5-58.64 misc (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt misc chiral nanoparticles misc circular dichroism misc glancing angle deposition misc optical activity misc Materials of engineering and construction. Mechanics of materials misc Information technology
topic_browse	misc TA401-492 misc T58.5-58.64 misc (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt misc chiral nanoparticles misc circular dichroism misc glancing angle deposition misc optical activity misc Materials of engineering and construction. Mechanics of materials misc Information technology
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title	Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
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title_full	Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
author_sort	Lin Yang
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author_browse	Lin Yang Junjun Liu Junhong Deng Zhifeng Huang
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title_sort	chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
callnumber	TA401-492
title_auth	Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
abstract	Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals.
abstractGer	Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals.
abstract_unstemmed	Abstract Sensitive differentiation of an enantiomer from its mirror image (ie, enantiodifferentiation), a perennial challenge for pharmaceutical production and disease diagnosis, is technically limited by the weak optical activity (OA) of enantiomers, mainly due to their dimensional mismatch with light wavelengths in the ultraviolet (UV)‐visible region. Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals.
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container_issue	6
title_short	Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers
url	https://doi.org/10.1002/inf2.12091 https://doaj.org/article/1c9bc90dbec8499b99c60d313623f7af https://doaj.org/toc/2567-3165
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author2	Junjun Liu Junhong Deng Zhifeng Huang
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doi_str	10.1002/inf2.12091
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up_date	2024-07-03T13:42:34.111Z
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Here we use silver chiral nanoparticles (Ag CNPs) with nominally sub‐5 nm helical pitch (P) to amplify the OA of (2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salts (RP), which have been found to indirectly affect metabolic processes, through the formation of an RP thin film (TF) covering a close‐packed array of Ag CNPs. The OA of the RP in the deep‐UV region can be amplified up to 80‐fold, ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs' surfaces. The former contribution, not associated with the chiral Ag topographies, plays a dominant role by thickening the RP TFs, so that the observed amplification has no enantioselective dependence on the chirality of the Ag CNPs. This study extends progress in the sensitive detection of bio‐enantiomers, which is highly desired for advanced bio‐detection in disease diagnosis and production of single‐enantiomer pharmaceuticals.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">(2′R, 3′R, 4′S)‐riboflavin‐5′‐phosphate sodium salt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">chiral nanoparticles</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">circular dichroism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">glancing angle deposition</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">optical activity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Materials of engineering and construction. 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Chiral nanoparticle‐induced amplification in optical activity of molecules with chiral centers

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