Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal

Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bajracharya L [verfasserIn] Bade AR [verfasserIn] Gurung R [verfasserIn] Dhakhwa K [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	microbial keratitis infective keratitis corneal ulcer

Übergeordnetes Werk:	In: Clinical Ophthalmology - Dove Medical Press, 2009, (2020), Seite 3219-3226
Übergeordnetes Werk:	year:2020 ; pages:3219-3226

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ060409517

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520			\|a Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer
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allfields	(DE-627)DOAJ060409517 (DE-599)DOAJ443712141fa94d26981a17666101ac8f DE-627 ger DE-627 rakwb eng RE1-994 Bajracharya L verfasserin aut Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer microbial keratitis infective keratitis corneal ulcer Ophthalmology Bade AR verfasserin aut Gurung R verfasserin aut Dhakhwa K verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2020), Seite 3219-3226 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2020 pages:3219-3226 https://doaj.org/article/443712141fa94d26981a17666101ac8f kostenfrei https://www.dovepress.com/demography-risk-factors-and-clinical-and-microbiological-features-of-m-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3219-3226
spelling	(DE-627)DOAJ060409517 (DE-599)DOAJ443712141fa94d26981a17666101ac8f DE-627 ger DE-627 rakwb eng RE1-994 Bajracharya L verfasserin aut Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer microbial keratitis infective keratitis corneal ulcer Ophthalmology Bade AR verfasserin aut Gurung R verfasserin aut Dhakhwa K verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2020), Seite 3219-3226 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2020 pages:3219-3226 https://doaj.org/article/443712141fa94d26981a17666101ac8f kostenfrei https://www.dovepress.com/demography-risk-factors-and-clinical-and-microbiological-features-of-m-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3219-3226
allfields_unstemmed	(DE-627)DOAJ060409517 (DE-599)DOAJ443712141fa94d26981a17666101ac8f DE-627 ger DE-627 rakwb eng RE1-994 Bajracharya L verfasserin aut Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer microbial keratitis infective keratitis corneal ulcer Ophthalmology Bade AR verfasserin aut Gurung R verfasserin aut Dhakhwa K verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2020), Seite 3219-3226 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2020 pages:3219-3226 https://doaj.org/article/443712141fa94d26981a17666101ac8f kostenfrei https://www.dovepress.com/demography-risk-factors-and-clinical-and-microbiological-features-of-m-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3219-3226
allfieldsGer	(DE-627)DOAJ060409517 (DE-599)DOAJ443712141fa94d26981a17666101ac8f DE-627 ger DE-627 rakwb eng RE1-994 Bajracharya L verfasserin aut Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer microbial keratitis infective keratitis corneal ulcer Ophthalmology Bade AR verfasserin aut Gurung R verfasserin aut Dhakhwa K verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2020), Seite 3219-3226 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2020 pages:3219-3226 https://doaj.org/article/443712141fa94d26981a17666101ac8f kostenfrei https://www.dovepress.com/demography-risk-factors-and-clinical-and-microbiological-features-of-m-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3219-3226
allfieldsSound	(DE-627)DOAJ060409517 (DE-599)DOAJ443712141fa94d26981a17666101ac8f DE-627 ger DE-627 rakwb eng RE1-994 Bajracharya L verfasserin aut Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer microbial keratitis infective keratitis corneal ulcer Ophthalmology Bade AR verfasserin aut Gurung R verfasserin aut Dhakhwa K verfasserin aut In Clinical Ophthalmology Dove Medical Press, 2009 (2020), Seite 3219-3226 (DE-627)560177089 (DE-600)2415713-2 11775483 nnns year:2020 pages:3219-3226 https://doaj.org/article/443712141fa94d26981a17666101ac8f kostenfrei https://www.dovepress.com/demography-risk-factors-and-clinical-and-microbiological-features-of-m-peer-reviewed-article-OPTH kostenfrei https://doaj.org/toc/1177-5483 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 3219-3226
language	English
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topic_facet	microbial keratitis infective keratitis corneal ulcer Ophthalmology
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Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. 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topic_title	RE1-994 Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal microbial keratitis infective keratitis corneal ulcer
topic	misc RE1-994 misc microbial keratitis misc infective keratitis misc corneal ulcer misc Ophthalmology
topic_unstemmed	misc RE1-994 misc microbial keratitis misc infective keratitis misc corneal ulcer misc Ophthalmology
topic_browse	misc RE1-994 misc microbial keratitis misc infective keratitis misc corneal ulcer misc Ophthalmology
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title	Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal
ctrlnum	(DE-627)DOAJ060409517 (DE-599)DOAJ443712141fa94d26981a17666101ac8f
title_full	Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal
author_sort	Bajracharya L
journal	Clinical Ophthalmology
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author_browse	Bajracharya L Bade AR Gurung R Dhakhwa K
class	RE1-994
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author2-role	verfasserin
title_sort	demography, risk factors, and clinical and microbiological features of microbial keratitis at a tertiary eye hospital in nepal
callnumber	RE1-994
title_auth	Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal
abstract	Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer
abstractGer	Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer
abstract_unstemmed	Leena Bajracharya,1 Asta Ram Bade,2 Reeta Gurung,1 Kavita Dhakhwa1 1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, NepalCorrespondence: Leena BajracharyaTilganga Institute of Ophthalmology, G.P.O Box: 561 Gaushala, Kathmandu, NepalTel +977 1 4493775Fax +977- 1- 4474937Email lbajrayahoo.comBackground: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management.Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities.Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin.Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.Key words: microbial keratitis, infective keratitis, corneal ulcer
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title_short	Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal
url	https://doaj.org/article/443712141fa94d26981a17666101ac8f https://www.dovepress.com/demography-risk-factors-and-clinical-and-microbiological-features-of-m-peer-reviewed-article-OPTH https://doaj.org/toc/1177-5483
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up_date	2024-07-03T14:46:37.082Z
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