Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data

The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and...
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Gespeichert in:

Autor*in:	Marica Iommi [verfasserIn] Martina Bonifazi [verfasserIn] Andrea Faragalli [verfasserIn] Lara Letizia Latini [verfasserIn] Federico Mei [verfasserIn] Liana Spazzafumo [verfasserIn] Edlira Skrami [verfasserIn] Luigi Ferrante [verfasserIn] Flavia Carle [verfasserIn] Rosaria Gesuita [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	idiopathic pulmonary fibrosis incidence temporal trend real-world data clinical epidemiology

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 19(2022), 2510, p 2510
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:2510, p 2510

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph19052510

Katalog-ID:	DOAJ060451815

Internformat


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allfields	10.3390/ijerph19052510 doi (DE-627)DOAJ060451815 (DE-599)DOAJ4ff691196cf9453d85ba0880ff17df23 DE-627 ger DE-627 rakwb eng Marica Iommi verfasserin aut Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking. idiopathic pulmonary fibrosis incidence temporal trend real-world data clinical epidemiology Medicine R Martina Bonifazi verfasserin aut Andrea Faragalli verfasserin aut Lara Letizia Latini verfasserin aut Federico Mei verfasserin aut Liana Spazzafumo verfasserin aut Edlira Skrami verfasserin aut Luigi Ferrante verfasserin aut Flavia Carle verfasserin aut Rosaria Gesuita verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2510, p 2510 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2510, p 2510 https://doi.org/10.3390/ijerph19052510 kostenfrei https://doaj.org/article/4ff691196cf9453d85ba0880ff17df23 kostenfrei https://www.mdpi.com/1660-4601/19/5/2510 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2510, p 2510
spelling	10.3390/ijerph19052510 doi (DE-627)DOAJ060451815 (DE-599)DOAJ4ff691196cf9453d85ba0880ff17df23 DE-627 ger DE-627 rakwb eng Marica Iommi verfasserin aut Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking. idiopathic pulmonary fibrosis incidence temporal trend real-world data clinical epidemiology Medicine R Martina Bonifazi verfasserin aut Andrea Faragalli verfasserin aut Lara Letizia Latini verfasserin aut Federico Mei verfasserin aut Liana Spazzafumo verfasserin aut Edlira Skrami verfasserin aut Luigi Ferrante verfasserin aut Flavia Carle verfasserin aut Rosaria Gesuita verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2510, p 2510 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2510, p 2510 https://doi.org/10.3390/ijerph19052510 kostenfrei https://doaj.org/article/4ff691196cf9453d85ba0880ff17df23 kostenfrei https://www.mdpi.com/1660-4601/19/5/2510 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2510, p 2510
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allfieldsSound	10.3390/ijerph19052510 doi (DE-627)DOAJ060451815 (DE-599)DOAJ4ff691196cf9453d85ba0880ff17df23 DE-627 ger DE-627 rakwb eng Marica Iommi verfasserin aut Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking. idiopathic pulmonary fibrosis incidence temporal trend real-world data clinical epidemiology Medicine R Martina Bonifazi verfasserin aut Andrea Faragalli verfasserin aut Lara Letizia Latini verfasserin aut Federico Mei verfasserin aut Liana Spazzafumo verfasserin aut Edlira Skrami verfasserin aut Luigi Ferrante verfasserin aut Flavia Carle verfasserin aut Rosaria Gesuita verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2510, p 2510 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2510, p 2510 https://doi.org/10.3390/ijerph19052510 kostenfrei https://doaj.org/article/4ff691196cf9453d85ba0880ff17df23 kostenfrei https://www.mdpi.com/1660-4601/19/5/2510 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2510, p 2510
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author	Marica Iommi
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topic_title	Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data idiopathic pulmonary fibrosis incidence temporal trend real-world data clinical epidemiology
topic	misc idiopathic pulmonary fibrosis misc incidence misc temporal trend misc real-world data misc clinical epidemiology misc Medicine misc R
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title	Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data
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title_full	Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data
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author_browse	Marica Iommi Martina Bonifazi Andrea Faragalli Lara Letizia Latini Federico Mei Liana Spazzafumo Edlira Skrami Luigi Ferrante Flavia Carle Rosaria Gesuita
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title_sort	occurrence of idiopathic pulmonary fibrosis in italy: latest evidence from real-world data
title_auth	Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data
abstract	The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking.
abstractGer	The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking.
abstract_unstemmed	The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking.
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title_short	Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data
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up_date	2024-07-03T15:02:50.455Z
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