Platinum Resistance in Ovarian Cancer: Role of DNA Repair

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing d...
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Gespeichert in:

Autor*in:	Giovanna Damia [verfasserIn] Massimo Broggini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	ovarian cancer nucleotide excision repair DNA damage response DNA repair homologous recombination DNA damaging agents cisplatin DNA polymorphisms gene mutations drug resistance

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 11(2019), 1, p 119
Übergeordnetes Werk:	volume:11 ; year:2019 ; number:1, p 119

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers11010119

Katalog-ID:	DOAJ060527153

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520			\|a Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs.
650		4	\|a ovarian cancer
650		4	\|a nucleotide excision repair
650		4	\|a DNA damage response
650		4	\|a DNA repair
650		4	\|a homologous recombination
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650		4	\|a DNA polymorphisms
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spelling	10.3390/cancers11010119 doi (DE-627)DOAJ060527153 (DE-599)DOAJ8485e68b42144a7698e9721331ed46e8 DE-627 ger DE-627 rakwb eng RC254-282 Giovanna Damia verfasserin aut Platinum Resistance in Ovarian Cancer: Role of DNA Repair 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs. ovarian cancer nucleotide excision repair DNA damage response DNA repair homologous recombination DNA damaging agents cisplatin DNA polymorphisms gene mutations drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Massimo Broggini verfasserin aut In Cancers MDPI AG, 2010 11(2019), 1, p 119 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:11 year:2019 number:1, p 119 https://doi.org/10.3390/cancers11010119 kostenfrei https://doaj.org/article/8485e68b42144a7698e9721331ed46e8 kostenfrei https://www.mdpi.com/2072-6694/11/1/119 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 1, p 119
allfields_unstemmed	10.3390/cancers11010119 doi (DE-627)DOAJ060527153 (DE-599)DOAJ8485e68b42144a7698e9721331ed46e8 DE-627 ger DE-627 rakwb eng RC254-282 Giovanna Damia verfasserin aut Platinum Resistance in Ovarian Cancer: Role of DNA Repair 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs. ovarian cancer nucleotide excision repair DNA damage response DNA repair homologous recombination DNA damaging agents cisplatin DNA polymorphisms gene mutations drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Massimo Broggini verfasserin aut In Cancers MDPI AG, 2010 11(2019), 1, p 119 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:11 year:2019 number:1, p 119 https://doi.org/10.3390/cancers11010119 kostenfrei https://doaj.org/article/8485e68b42144a7698e9721331ed46e8 kostenfrei https://www.mdpi.com/2072-6694/11/1/119 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 1, p 119
allfieldsGer	10.3390/cancers11010119 doi (DE-627)DOAJ060527153 (DE-599)DOAJ8485e68b42144a7698e9721331ed46e8 DE-627 ger DE-627 rakwb eng RC254-282 Giovanna Damia verfasserin aut Platinum Resistance in Ovarian Cancer: Role of DNA Repair 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs. ovarian cancer nucleotide excision repair DNA damage response DNA repair homologous recombination DNA damaging agents cisplatin DNA polymorphisms gene mutations drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Massimo Broggini verfasserin aut In Cancers MDPI AG, 2010 11(2019), 1, p 119 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:11 year:2019 number:1, p 119 https://doi.org/10.3390/cancers11010119 kostenfrei https://doaj.org/article/8485e68b42144a7698e9721331ed46e8 kostenfrei https://www.mdpi.com/2072-6694/11/1/119 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 1, p 119
allfieldsSound	10.3390/cancers11010119 doi (DE-627)DOAJ060527153 (DE-599)DOAJ8485e68b42144a7698e9721331ed46e8 DE-627 ger DE-627 rakwb eng RC254-282 Giovanna Damia verfasserin aut Platinum Resistance in Ovarian Cancer: Role of DNA Repair 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs. ovarian cancer nucleotide excision repair DNA damage response DNA repair homologous recombination DNA damaging agents cisplatin DNA polymorphisms gene mutations drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Massimo Broggini verfasserin aut In Cancers MDPI AG, 2010 11(2019), 1, p 119 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:11 year:2019 number:1, p 119 https://doi.org/10.3390/cancers11010119 kostenfrei https://doaj.org/article/8485e68b42144a7698e9721331ed46e8 kostenfrei https://www.mdpi.com/2072-6694/11/1/119 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 1, p 119
language	English
source	In Cancers 11(2019), 1, p 119 volume:11 year:2019 number:1, p 119
sourceStr	In Cancers 11(2019), 1, p 119 volume:11 year:2019 number:1, p 119
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ovarian cancer nucleotide excision repair DNA damage response DNA repair homologous recombination DNA damaging agents cisplatin DNA polymorphisms gene mutations drug resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Giovanna Damia @@aut@@ Massimo Broggini @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Giovanna Damia
spellingShingle	Giovanna Damia misc RC254-282 misc ovarian cancer misc nucleotide excision repair misc DNA damage response misc DNA repair misc homologous recombination misc DNA damaging agents misc cisplatin misc DNA polymorphisms misc gene mutations misc drug resistance misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Platinum Resistance in Ovarian Cancer: Role of DNA Repair
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topic_title	RC254-282 Platinum Resistance in Ovarian Cancer: Role of DNA Repair ovarian cancer nucleotide excision repair DNA damage response DNA repair homologous recombination DNA damaging agents cisplatin DNA polymorphisms gene mutations drug resistance
topic	misc RC254-282 misc ovarian cancer misc nucleotide excision repair misc DNA damage response misc DNA repair misc homologous recombination misc DNA damaging agents misc cisplatin misc DNA polymorphisms misc gene mutations misc drug resistance misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc ovarian cancer misc nucleotide excision repair misc DNA damage response misc DNA repair misc homologous recombination misc DNA damaging agents misc cisplatin misc DNA polymorphisms misc gene mutations misc drug resistance misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Platinum Resistance in Ovarian Cancer: Role of DNA Repair
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title_full	Platinum Resistance in Ovarian Cancer: Role of DNA Repair
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title_sort	platinum resistance in ovarian cancer: role of dna repair
callnumber	RC254-282
title_auth	Platinum Resistance in Ovarian Cancer: Role of DNA Repair
abstract	Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs.
abstractGer	Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs.
abstract_unstemmed	Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we focused our attention on DNA repair mechanisms, which are fundamental for recognition and removal of platinum adducts and hence for the ability of these drugs to exert their activity. We analyzed the major DNA repair pathways potentially involved in drug resistance, detailing gene mutation, duplication or deletion as well as polymorphisms as potential biomarkers for drug resistance development. We dissected potential ways to overcome DNA repair-associated drug resistance thanks to the development of new combinations and/or drugs directly targeting DNA repair proteins or taking advantage of the vulnerability arising from DNA repair defects in EOCs.
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title_short	Platinum Resistance in Ovarian Cancer: Role of DNA Repair
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