Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent...
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Autor*in:	Shaheen S. Sikandar [verfasserIn] Angera H. Kuo [verfasserIn] Tomer Kalisky [verfasserIn] Shang Cai [verfasserIn] Maider Zabala [verfasserIn] Robert W. Hsieh [verfasserIn] Neethan A. Lobo [verfasserIn] Ferenc A. Scheeren [verfasserIn] Sopheak Sim [verfasserIn] Dalong Qian [verfasserIn] Frederick M. Dirbas [verfasserIn] George Somlo [verfasserIn] Stephen R. Quake [verfasserIn] Michael F. Clarke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 9
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-017-01666-2

Katalog-ID:	DOAJ060554983

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author	Shaheen S. Sikandar
spellingShingle	Shaheen S. Sikandar misc Science misc Q Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
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topic_title	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
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title	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
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title_full	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
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author_browse	Shaheen S. Sikandar Angera H. Kuo Tomer Kalisky Shang Cai Maider Zabala Robert W. Hsieh Neethan A. Lobo Ferenc A. Scheeren Sopheak Sim Dalong Qian Frederick M. Dirbas George Somlo Stephen R. Quake Michael F. Clarke
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title_sort	role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
title_auth	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
abstract	The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.
abstractGer	The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.
abstract_unstemmed	The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.
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title_short	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
url	https://doi.org/10.1038/s41467-017-01666-2 https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c https://doaj.org/toc/2041-1723
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Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

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