In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists bet...
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Autor*in:	Nicholas C. Wu [verfasserIn] Geramie Grande [verfasserIn] Hannah L. Turner [verfasserIn] Andrew B. Ward [verfasserIn] Jia Xie [verfasserIn] Richard A. Lerner [verfasserIn] Ian A. Wilson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 12
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/ncomms15371

Katalog-ID:	DOAJ060556986

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spelling	10.1038/ncomms15371 doi (DE-627)DOAJ060556986 (DE-599)DOAJ288a464640f848a88e3527b72a95a760 DE-627 ger DE-627 rakwb eng Nicholas C. Wu verfasserin aut In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists between Ab affinity and breadth that influenced by disparate modes of receptor binding. Science Q Geramie Grande verfasserin aut Hannah L. Turner verfasserin aut Andrew B. Ward verfasserin aut Jia Xie verfasserin aut Richard A. Lerner verfasserin aut Ian A. Wilson verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:12 https://doi.org/10.1038/ncomms15371 kostenfrei https://doaj.org/article/288a464640f848a88e3527b72a95a760 kostenfrei https://doi.org/10.1038/ncomms15371 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 12
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author	Nicholas C. Wu
spellingShingle	Nicholas C. Wu misc Science misc Q In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
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topic_title	In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
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title	In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
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title_full	In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
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author_browse	Nicholas C. Wu Geramie Grande Hannah L. Turner Andrew B. Ward Jia Xie Richard A. Lerner Ian A. Wilson
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title_sort	in vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
title_auth	In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
abstract	Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists between Ab affinity and breadth that influenced by disparate modes of receptor binding.
abstractGer	Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists between Ab affinity and breadth that influenced by disparate modes of receptor binding.
abstract_unstemmed	Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists between Ab affinity and breadth that influenced by disparate modes of receptor binding.
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title_short	In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity
url	https://doi.org/10.1038/ncomms15371 https://doaj.org/article/288a464640f848a88e3527b72a95a760 https://doaj.org/toc/2041-1723
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author2	Geramie Grande Hannah L. Turner Andrew B. Ward Jia Xie Richard A. Lerner Ian A. Wilson
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up_date	2024-07-03T15:41:14.382Z
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